Cell softness dictates sensitivity to force
Nature Materials
2009년10월19일
How a cell responds to localized stresses acting on it depends on the 'softness' of the cell itself, reports a study published online this week in Nature Materials. This suggests that small physical forces acting on cells might have far more important roles in early developments of soft embryos than previously thought.
Ning Wang and colleagues found that individual mouse embryonic stem cells, which are very soft, spread when a small oscillating local stress is applied to one side of the cell. In contrast, cells that are tenfold stiffer do not react to the same level of stress. However when the stiff cells are artificially softened, they react similarly to the soft stem cells.
It had already been shown that the rigidity of materials that the cell attaches to have a large influence on cell response. This study now shows that how much the cell's structure is deformed by a force is the primary factor that determines the extent of the cell's response.
doi: 10.1038/nmat2563
리서치 하이라이트
-
7월7일
Public health: Tackling adolescent stressNature
-
6월23일
Scientific community: Women credited less than men in scientific paper authorshipNature
-
5월12일
Geoscience: Monitoring earthquakes at the speed of lightNature
-
5월4일
Microbiology: Bacteriophage therapy helps treat multi-drug resistant infection in an immunocompromised patientNature Communications
-
4월27일
Planetary science: Building blocks of DNA detected in meteoritesNature Communications
-
4월8일
Health: Psilocybin use associated with lower risk of opioid addictionScientific Reports
