Fourier’s transformational thinking p.413

The mathematics of Joseph Fourier, born 250 years ago this week, shows the value of intellectual boldness.

doi: 10.1038/d41586-018-03389-w

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How to get public engagement right p.413

Dialogue with the public requires a nuanced approach and a willingness to accept uncomfortable truths.

doi: 10.1038/d41586-018-03388-x

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Asymmetry symposium unites economists, physicists and artists p.414

Transdisciplinary programme explores the pervasive presence of symmetry violations.

doi: 10.1038/d41586-018-03254-w

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Deadly Lassa-fever outbreak tests Nigeria's revamped health agency p.421

Reforms put in place after Ebola epidemic in West Africa have built Nigeria's capacity to diagnose diseases and track their spread.

doi: 10.1038/d41586-018-03171-y

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いったんは削除されたJeffrey Beall氏の「ハゲタカジャーナル」リストを引き継ぐウェブサイトが。

The undercover academic keeping tabs on ‘predatory’ publishing p.422

Blacklists that warn against questionable publishers are in demand.

doi: 10.1038/d41586-018-02921-2

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Science mourns Stephen Hawking’s death p.423

Physicist and icon of science dies aged 76.

doi: 10.1038/d41586-018-02957-4

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Advances in human behaviour came surprisingly early in Stone Age p.424

Excavations in Kenya suggest improvements in stone tools and other human changes are linked to variations in climate.

doi: 10.1038/d41586-018-03244-y

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Chinese leaders create science mega-ministry p.425

Overhaul prompts fears of an erosion in funding for basic science.

doi: 10.1038/d41586-018-03246-w

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News Features


How human embryonic stem cells sparked a revolution p.428


doi: 10.1038/d41586-018-03268-4

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When antibiotics turn toxic p.431


doi: 10.1038/d41586-018-03267-5

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News & Views


Medical research: Machine learning classifies cancer p.446


doi: 10.1038/d41586-018-02881-7

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Applied physics: A diamond age of masers p.447


doi: 10.1038/d41586-018-03215-3

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Neurodegeneration: Protein aggregates caught stalling p.449


doi: 10.1038/d41586-018-03000-2

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Solar system: Calcium signals in planetary embryos p.451


doi: 10.1038/d41586-018-03144-1

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Neurodevelopment: A mixed model of neuronal diversity p.452


doi: 10.1038/d41586-018-02539-4

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Plant biology: A cellular passage to the root interior p.454


doi: 10.1038/d41586-018-02861-x

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Developmental diversification of cortical inhibitory interneurons p.457

The embryonic emergence of interneuron subtypes in mice is revealed by integrated single-cell transcriptomic analysis along a developmental time course.

doi: 10.1038/nature25999

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Placentation defects are highly prevalent in embryonic lethal mouse mutants p.463

Analysis of embryonic lethal and sub-viable mouse knockout lines reveals that ablation of many genes affects placental development, and that the occurrence of placental defects is co-associated with abnormal brain, heart and vascular system development.

doi: 10.1038/nature26002

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DNA methylation-based classification of central nervous system tumours p.469

An online approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups has been developed to help to improve current diagnostic standards.

doi: 10.1038/nature26000

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Integrative structure and functional anatomy of a nuclear pore complex p.475

The structure of the yeast nuclear pore complex, determined with sub-nanometre precision using an integrative approach that combines a wide range of data, reveals details of its architecture, transport mechanism and evolutionary origins.

doi: 10.1038/nature26003

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天文学:大質量のコンパクトな銀河NGC 1277周辺にある単一種族の赤色球状星団

A single population of red globular clusters around the massive compact galaxy NGC 1277 p.483

The massive relic galaxy NGC 1277 has few blue globular clusters, indicating that it has undergone little mass accretion and is a candidate ‘red nugget’ in the nearby Universe.

doi: 10.1038/nature25756

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Image reconstruction by domain-transform manifold learning p.487

Image reconstruction is reformulated using a data-driven, supervised machine learning framework that allows a mapping between sensor and image domains to emerge from even noisy and undersampled data, improving accuracy and reducing image artefacts.

doi: 10.1038/nature25988

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Continuous-wave room-temperature diamond maser p.493

The maser—the microwave progenitor of the optical laser—has been confined to relative obscurity owing to its reliance on cryogenic refrigeration and high-vacuum systems. Despite this, it has found application in deep-space communications and radio astronomy owing to its unparalleled performance as a low-noise amplifier and oscillator. The recent demonstration of a room-temperature solidstate maser that utilizes polarized electron populations within the triplet states of photo-excited pentacene molecules in a p-terphenyl host1–3 paves the way for a new class of maser. However, p-terphenyl has poor thermal and mechanical properties, and the decay rates of the triplet sublevel of pentacene mean that only pulsed maser operation has been observed in this system. Alternative materials are therefore required to achieve continuous emission: inorganic materials that contain spin defects, such as diamond4–6 and silicon carbide7, have been proposed. Here we report a continuous-wave room-temperature maser oscillator using optically pumped nitrogen–vacancy defect centres in diamond. This demonstration highlights the potential of room-temperature solid-state masers for use in a new generation of microwave devices that could find application in medicine, security, sensing and quantum technologies.

doi: 10.1038/nature25970

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Maximizing and stabilizing luminescence from halide perovskites with potassium passivation p.497

Modifying the surfaces and grain boundaries of perovskites with passivating potassium halide layers can mitigate non-radiative losses and photoinduced ion migration, increasing luminescence yields and improving charge transport and interfaces with device electrodes.

doi: 10.1038/nature25989

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A lithium–oxygen battery with a long cycle life in an air-like atmosphere p.502

A lithium–oxygen battery, comprising a lithium carbonate-based protected anode, a molybdenum disulfide cathode and an ionic liquid/dimethyl sulfoxide electrolyte, operates in a simulated air atmosphere with a long cycle life of up to 700 cycles.

doi: 10.1038/nature25984

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Isotopic evolution of the protoplanetary disk and the building blocks of Earth and the Moon p.507

The mass-independent calcium isotope composition of inner-Solar-System bodies is correlated with their masses and accretion ages, indicating a rapid growth for the precursors of Earth and the Moon during the protoplanetary disk’s lifetime.

doi: 10.1038/nature25990

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Humans thrived in South Africa through the Toba eruption about 74,000 years ago p.511

Youngest Toba Tuff glass shards found together with evidence of human occupation at two archaeological sites from the southern coast of South Africa indicate that early modern humans thrived in this region despite the eruption of the Toba supervolcano about 74,000 years ago.

doi: 10.1038/nature25967

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Carbon dioxide addition to coral reef waters suppresses net community calcification p.516

In situ carbon dioxide enrichment experiments show that ocean acidification poses a threat to coral reefs by reducing the saturation state of aragonite and the concentration of carbonate ions and that this impairs community calcification.

doi: 10.1038/nature25968

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Dysregulation of expression correlates with rare-allele burden and fitness loss in maize p.520

A multi-tissue gene expression resource representative of the genotypic and phenotypic diversity of modern inbred maize reveals the effect of rare alleles and evolutionary history on the regulation of gene expression.

doi: 10.1038/nature25966

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A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex p.524

Analysis of gene expression at single-cell resolution in the developing prefrontal cortex of the human embryo reveals a diversity of cell types, elucidates cell lineages and identifies signalling pathways that regulate development.

doi: 10.1038/nature25980

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Diffusible repression of cytokinin signalling produces endodermal symmetry and passage cells p.529

In an Arabidopsis model, repression of cytokinin in the root meristem produces a distinct population of xylem-pole endodermal cells, which resist suberization to become passage cells that enable transport across the otherwise-impermeable endodermis.

doi: 10.1038/nature25976

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Carbonate-sensitive phytotransferrin controls high-affinity iron uptake in diatoms p.534

Phytotransferrin, a functional analogue of transferrin, has an obligate requirement for carbonate to bind iron, which suggests that acidification-driven declines in the concentration of seawater carbonate ions may negatively affect diatom iron acquisition.

doi: 10.1038/nature25982

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The cis-regulatory dynamics of embryonic development at single-cell resolution p.538

An improved assay for chromatin accessibility at single-cell resolution in Drosophila melanogaster embryos enables identification of developmental-stage- and cell-lineage-specific patterns of chromatin-level transcriptional regulation.

doi: 10.1038/nature25981

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