Science must examine the future of work p.301

As automation changes employment, researchers should gather the evidence to help map the implications.

doi: 10.1038/550301b

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米国の政治家たちは、炭素観測衛星OCO-2(Orbiting Carbon Observatory-2)によって得られた最新のデータに目を向けるべきだ。

Eye in the sky offers clearest vision of Earth p.301

Time to think about how automation will affect employement.

doi: 10.1038/550301a

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Blue is in the eye of the bee-holder p.302

Flowers have evolved an ingenious way to attract pollinators.

doi: 10.1038/550302a

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Colliding stars spark rush to solve cosmic mysteries p.309

Stellar collision confirms theoretical predictions about the periodic table.

doi: 10.1038/550309a

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Japanese research leaders warn about national science decline p.310

Concern mounts over budget cuts and other changes that undermine basic science.

doi: 10.1038/550310a

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Trump EPA begins push to overturn Obama-era climate regulation p.311

The agency's plan to reverse limits on greenhouse-gas emissions is likely to draw legal challenges.

doi: 10.1038/nature.2017.22813

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New definitions of scientific units are on the horizon p.312

Metrologists are poised to change how scientists measure the Universe.

doi: 10.1038/550312a

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FDA advisers back gene therapy for rare form of blindness p.314

Therapy that targets disease-causing mutations could become the first of its kind approved for use in the United States.

doi: 10.1038/nature.2017.22819

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News Features


The future of work p.315


doi: 10.1038/550315a

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The shape of work to come p.316


doi: 10.1038/550316a

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News & Views


Artificial intelligence: Learning to play Go from scratch p.336


doi: 10.1038/550336a

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Cancer treatment: Bacterial snack attack deactivates a drug p.337


doi: 10.1038/550337a

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Computer science: Data analysis meets quantum physics p.339


doi: 10.1038/550339a

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Cancer biology: Genome jail-break triggers lockdown p.340


doi: 10.1038/nature24146

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Biochemistry: Complex assistance for DNA invasion p.342


doi: 10.1038/nature24149

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Neurobiology: Domains to the rescue for Rett syndrome p.343


doi: 10.1038/nature24151

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DNA sequencing at 40: past, present and future p.345

The history and future potential of DNA sequencing, including the development of the underlying technologies and the expansion of its areas of application, are reviewed.

doi: 10.1038/nature24286

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Mastering the game of Go without human knowledge p.354

Starting from zero knowledge and without human data, AlphaGo Zero was able to teach itself to play Go and to develop novel strategies that provide new insights into the oldest of games.

doi: 10.1038/nature24270

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BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing p.360

The tumour suppressor complex BRCA1–BARD1, which facilitates the generation of a single-stranded DNA template during homologous recombination, also binds to the recombinase RAD51 and enhances its function.

doi: 10.1038/nature24060

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Human TRPML1 channel structures in open and closed conformations p.366

Two structures of human transient receptor potential mucolipin 1 (TRPML1), in the closed and agonist-bound open states, have been resolved by electron cryo-microscopy.

doi: 10.1038/nature24036

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A parts-per-billion measurement of the antiproton magnetic moment p.371

The magnetic moment of the antiproton is measured at the parts-per-billion level, improving on previous measurements by a factor of about 350.

doi: 10.1038/nature24048

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Solving a Higgs optimization problem with quantum annealing for machine learning p.375

A machine learning algorithm implemented on a quantum annealer—a D-Wave machine with 1,098 superconducting qubits—is used to identify Higgs-boson decays from background standard-model processes.

doi: 10.1038/nature24047

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Ion sieving in graphene oxide membranes via cationic control of interlayer spacing p.380

Cations are used to control the interlayer spacing of graphene oxide membranes, enabling efficient and selective sieving of hydrated cations.

doi: 10.1038/nature24044

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Organic long persistent luminescence p.384

A blend of two organic molecules excited by a simple LED light source can release the stored excitation energy slowly as ‘long persistent luminescence’ over periods of up to an hour.

doi: 10.1038/nature24010

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Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex p.388

Interactions with male and female intruders activated overlapping neuronal populations in the ventromedial hypothalamus of inexperienced adult male mice, and these ensembles gradually separated as the mice acquired social and sexual experience with conspecifics.

doi: 10.1038/nature23885

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Establishment of mouse expanded potential stem cells p.393

Cultures of expanded potential stem cells can be established from individual eight-cell blastomeres, and by direct conversion of mouse embryonic stem cells and induced pluripotent stem cells, highlighting the feasibility of establishing expanded potential stem cells for other mammalian species.

doi: 10.1038/nature24052

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Radically truncated MeCP2 rescues Rett syndrome-like neurological defects p.398

Analysis of the minimal functional unit for MeCP2 protein shows that its function is to recruit the NCoR/SMRT co-repressor complex to methylated sites on chromatin, which may have use in designing strategies for gene therapy of Rett syndrome.

doi: 10.1038/nature24058

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Cytoplasmic chromatin triggers inflammation in senescence and cancer p.402

Cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer.

doi: 10.1038/nature24050

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Enhanced proofreading governs CRISPR–Cas9 targeting accuracy p.407

A new engineered version of SpCas9, called HypaCas9, displays enhanced accuracy of editing without significant loss of efficiency at the desired target.

doi: 10.1038/nature24268

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Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3 p.411

A cryo-electron microscopy structure shows that the mucolipin domain of the lysosomal calcium channel TRPML3 binds phosphatidylinositol-3,5-bisphosphate and gates the channel.

doi: 10.1038/nature24055

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Structure of mammalian endolysosomal TRPML1 channel in nanodiscs p.415

The structure of mouse transient receptor potential mucolipin 1 (TRPML1), a cation channel located within endosomal and lysosomal membranes, is resolved using single-particle electron cryo-microscopy.

doi: 10.1038/nature24035

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