Pulsars still dazzle after 50 years p.5

The Universe’s flash machines have proven their scientific value.

doi: 10.1038/547005b

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Biology of single cells shines a light on collaboration p.5

New tools for exploring the individual characteristics of cells are attracting researchers from other disciplines.

doi: 10.1038/547005a

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Helium should be recycled p.6

The geopolitical crisis in the Middle East highlights the vulnerability of supplies of an essential research resource.

doi: 10.1038/547006a

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Google spin-off deploys wearable electronics for huge health study p.13

Large projects explore how to integrate data from smart devices with other health metrics.

doi: 10.1038/547013a

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Ebola outbreak in Africa ends — but gaps in public health leave region vulnerable p.14

Experts say effective response to the outbreak in the Democratic Republic of the Congo helped prevent the virus from spreading.

doi: 10.1038/nature.2017.22227

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Has Harry Potter mania cursed Indonesia's owls? p.15

Conservationists fear trend of selling wild-caught birds will hurt populations.

doi: 10.1038/nature.2017.22198

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Qatar blockade hits helium supply p.16

Researchers braced for shortages as Gulf state forced to close its refineries.

doi: 10.1038/547016a

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Europe’s next big science-funding programme urged to double its budget p.17

Influential report suggests simpler, more citizen-friendly system for post-2020 EU research funding.

doi: 10.1038/547017a

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News Features


Single-cell biology p.19


doi: 10.1038/547019a

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The trickiest family tree in biology p.20


doi: 10.1038/547020a

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How to build a human cell atlas p.24

米国ブロード研究所のAviv Regevは、単一細胞をゲノミクス手法を用いて調べ、人体の全細胞をマッピングしようと取り組んでいる。

doi: 10.1038/547024a

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News & Views


Cell cycle: Continuous chromatin changes p.34


doi: 10.1038/547034a

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Palaeoclimatology: Ice-sheet history revealed by fossils p.35


doi: 10.1038/547035a

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Immunology: The patterns of T-cell target recognition p.36


doi: 10.1038/nature23091

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Electronics: 3D integration advances computing p.38


doi: 10.1038/547038a

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Cancer genomics: Less is more in the hunt for driver mutations p.40


doi: 10.1038/nature23085

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Astrophysics: Stellar siblings grow closer with age p.41


doi: 10.1038/nature23092

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West Antarctic Ice Sheet retreat driven by Holocene warm water incursions p.43

During the early Holocene epoch—and since the 1940s—variations in Southern Hemisphere westerly winds controlled the upwelling of Circumpolar Deep Water and seemingly ice-sheet retreat in West Antarctica.

doi: 10.1038/nature22995

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Climate change drives expansion of Antarctic ice-free habitat p.49

Permanently ice-free areas, home to almost all of Antarctica’s biodiversity, are projected, in the worst case, to expand by over 17,000 km2 as a result of climate change by the end of this century, with potentially deleterious consequences for the continent’s biodiversity.

doi: 10.1038/nature22996

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Recurrent and functional regulatory mutations in breast cancer p.55

High-depth sequencing of targeted regions in primary breast cancer identifies mutated promoter elements with recurrent mutations at specific and/or nearby bases, suggesting selection of certain non-coding events.

doi: 10.1038/nature22992

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Cell-cycle dynamics of chromosomal organization at single-cell resolution p.61

Single-cell Hi-C analysis in thousands of mouse embryonic stem cells shows that chromosomal compartments, topological-associated domains and long-range loops all have distinct cell-cycle dynamics.

doi: 10.1038/nature23001

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Single-molecule analysis of ligand efficacy in β2AR–G-protein activation p.68

Single-molecule FRET imaging provides insights into the allosteric link between the ligand-binding and G-protein nucleotide-binding pockets of the β2 adrenergic receptor (β2AR) and improved understanding of the G-protein activation mechanism.

doi: 10.1038/nature22354

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Three-dimensional integration of nanotechnologies for computing and data storage on a single chip p.74

Multiple nanotechnologies are integrated on a single chip to realize a three-dimensional integrated circuit architecture that combines computing and data storage—a potentially transformative advance in computing.

doi: 10.1038/nature22994

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化学:極性マッチングに基づくクロスカップリングによる選択的sp3 C–Hアルキル化

Selective sp3 C–H alkylation via polarity-match-based cross-coupling p.79

The functionalization of carbon–hydrogen (C–H) bonds is one of the most attractive strategies for molecular construction in organic chemistry. The hydrogen atom is considered to be an ideal coupling handle, owing to its relative abundance in organic molecules and its availability for functionalization at almost any stage in a synthetic sequence. Although many C–H functionalization reactions involve C(sp3)–C(sp2) coupling, there is a growing demand for C–H alkylation reactions, wherein sp3 C–H bonds are replaced with sp3 C–alkyl groups. Here we describe a polarity-match-based selective sp3 C–H alkylation via the combination of photoredox, nickel and hydrogen-atom transfer catalysis. This methodology simultaneously uses three catalytic cycles to achieve hydridic C–H bond abstraction (enabled by polarity matching), alkyl halide oxidative addition, and reductive elimination to enable alkyl–alkyl fragment coupling. The sp3 C–H alkylation is highly selective for the α-C–H of amines, ethers and sulphides, which are commonly found in pharmaceutically relevant architectures. This cross-coupling protocol should enable broad synthetic applications in de novo synthesis and late-stage functionalization chemistry.

doi: 10.1038/nature22813

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Episodic kinematics in continental rifts modulated by changes in mantle melt fraction p.84

GPS measurements are used to investigate the continental rift system of North Island, New Zealand, and to develop a model for short-term deformation involving flexing of an elastic upper crust caused by episodic changes in mantle viscosity and melt fraction.

doi: 10.1038/nature22962

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Quantifiable predictive features define epitope-specific T cell receptor repertoires p.89

The authors characterize epitope-specific T cell repertoires, identify shared and recognizable features of TCRs, and develop tools to classify antigen specificity on the basis of sequence analysis.

doi: 10.1038/nature22383

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Identifying specificity groups in the T cell receptor repertoire p.94

The authors devise an algorithm that can cluster T cell receptor (TCR) sequences sharing the same specificity, predict the HLA restriction of these TCR clusters on the basis of subjects’ genotypes and help to identify specific peptide major histocompatibility complex ligands.

doi: 10.1038/nature22976

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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin p.99

Chemotherapy drugs can cause pyroptotic cell death by activating caspase-3 to cleave gasdermin E, potentially contributing to their toxicity and adverse effects.

doi: 10.1038/nature22393

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Tracing the origins of relapse in acute myeloid leukaemia to stem cells p.104

Identification of the cell types from which relapse arises in acute myeloid leukaemia, by following leukaemia propagation from patient-derived leukaemia samples.

doi: 10.1038/nature22993

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mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer p.109

mTOR complex 1 signalling regulates polyamine metabolism and thereby promotes tumorigenesis, through regulation of the stability of a key enzyme, AMD1.

doi: 10.1038/nature22964

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RNase III nucleases from diverse kingdoms serve as antiviral effectors p.114

RNase III from all three domains of life elicits RNA-targeting antiviral activity that is independent of, and possibly predates, other known eukaryotic antiviral systems.

doi: 10.1038/nature22990

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Electron cryo-microscopy structure of the mechanotransduction channel NOMPC p.118

Single-particle electron cryo-microscopy analysis of the mechanotransduction channel NOMPC reveals that it contains a bundle of four helical spring-shaped ankyrin repeat domains that undergo motion, potentially allowing mechanical movement of the cytoskeleton to be coupled to the opening of the channel.

doi: 10.1038/nature22981

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