CRISPR helps evo-devo scientists to unpick the origins of adaptions p.249

Modern gene-editing tools are being used to understand the mechanisms of evolution.

doi: 10.1038/536249b

Full Text


Rare rewards p.249

A catalogue of genetic information from some 60,000 people reveals unexpected surprises — and highlights the need to make genomic data publicly accessible to aid studies of rare diseases.

doi: 10.1038/536249a

Full Text



Mosquito guns and heavy fines: how Cuba kept Zika at bay for so long p.257

It is one of the last Caribbean countries to get hit.

doi: 10.1038/536257a

Full Text


Artificial black hole creates its own version of Hawking radiation p.258

Result could be closest thing yet to an observation of the bizarre phenomenon.

doi: 10.1038/536258a

Full Text

アラブ初のノーベル賞受賞者Ahmed Zewailの死去で、エジプトの科学技術都市の今後に懸念が。

Nobel laureate’s death highlights struggles at Egyptian science hub p.260

Cash-strapped Zewail City of Science and Technology is the legacy of Arab chemist Ahmed Zewail.

doi: 10.1038/nature.2016.20408

Full Text


Trump’s border-wall pledge threatens delicate desert ecosystems p.260

Ecologists fear plan to seal off the United States from Mexico would put wildlife at risk.

doi: 10.1038/536260a

Full Text


Morphing neutrinos provide clue to antimatter mystery p.261

Excitement rises over chance of new physics from particle-du-jour.

doi: 10.1038/nature.2016.20405

Full Text

News Features


Bottles, bags, ropes and toothbrushes: the struggle to track ocean plastics p.263


doi: 10.1038/536263a

Full Text


The plastics revolution: how chemists are pushing polymers to new limits p.266


doi: 10.1038/536266a

Full Text

News & Views


In retrospect: Sixty years of living polymers p.276


doi: 10.1038/536276a

Full Text


Human genomics: A deep dive into genetic variation p.277


doi: 10.1038/536277a

Full Text


Neuroscience: Flipping the sleep switch p.278


doi: 10.1038/nature18918

Full Text


Catalysis: Elusive active site in focus p.280


doi: 10.1038/536280a

Full Text


Mammalian development: Mechanics drives cell differentiation p.281


doi: 10.1038/nature18920

Full Text


Condensed-matter physics: Superconducting electrons go missing p.282


doi: 10.1038/536282a

Full Text



Analysis of protein-coding genetic variation in 60,706 humans OPEN p.285

Exome sequencing data from 60,706 people of diverse geographic ancestry is presented, providing insight into genetic variation across populations, and illuminating the relationship between DNA variants and human disease.

doi: 10.1038/nature19057

日本語要約 | Full Text | PDF


Circadian neuron feedback controls the Drosophila sleep–activity profile p.292

A subset of dorsal clock neurons are identified in Drosophila as sleep-promoting cells, which participate in a feedback loop with pacemaker neurons to drive both midday siesta and night-time sleep.

doi: 10.1038/nature19097

日本語要約 | Full Text | PDF


Defining the clonal dynamics leading to mouse skin tumour initiation p.298

Skin stem cells, but not their progenitors, are able to form tumours owing to the ability of oncogene-targeted stem cells to increase symmetric self-renewing division and a higher p53-dependent resistance to apoptosis.

doi: 10.1038/nature19069

日本語要約 | Full Text | PDF

生化学:活性化RING E3/E2–SUMO複合体における基質の捕捉

Capturing a substrate in an activated RING E3/E2–SUMO complex p.304

A new method based on protein engineering to trap an intact complex between Siz1, SUMO-bound E2, and PCNA for structure determination.

doi: 10.1038/nature19071

日本語要約 | Full Text | PDF



Dependence of the critical temperature in overdoped copper oxides on superfluid density p.309

The scaling law for the critical temperature and zero-temperature stiffness in an overdoped copper oxide semiconductor does not conform to the standard Bardeen–Cooper–Schrieffer description.

doi: 10.1038/nature19061

日本語要約 | Full Text | PDF


High-efficiency two-dimensional Ruddlesden–Popper perovskite solar cells p.312

Thin-film solar cells were fabricated using layered two-dimensional perovskites with near-single-crystalline out-of-plane alignment, which facilitates efficient charge transport leading to greatly improved power conversion efficiency with technologically relevant stability to light exposure, humidity and heat stress.

doi: 10.1038/nature18306

日本語要約 | Full Text | PDF


The active site of low-temperature methane hydroxylation in iron-containing zeolites p.317

Iron-containing zeolites have an exceptional ability to convert methane into methanol, but their active site have been hard to study; now, magnetic circular dichroism has been used to explore the reactive species, providing a technique that should be generally applicable, and revealing the value of constraining active sites within a lattice to improve catalyst functionality.

doi: 10.1038/nature19059

日本語要約 | Full Text | PDF


Metallaphotoredox-catalysed sp3sp3 cross-coupling of carboxylic acids with alkyl halides p.322

In the past 50 years, cross-coupling reactions mediated by transition metals have changed the way in which complex organic molecules are synthesized. The predictable and chemoselective nature of these transformations has led to their widespread adoption across many areas of chemical research. However, the construction of a bond between two sp3-hybridized carbon atoms, a fundamental unit of organic chemistry, remains an important yet elusive objective for engineering cross-coupling reactions. In comparison to related procedures with sp2-hybridized species, the development of methods for sp3sp3 bond formation via transition metal catalysis has been hampered historically by deleterious side-reactions, such as β-hydride elimination with palladium catalysis or the reluctance of alkyl halides to undergo oxidative addition. To address this issue, nickel-catalysed cross-coupling processes can be used to form sp3sp3 bonds that utilize organometallic nucleophiles and alkyl electrophiles. In particular, the coupling of alkyl halides with pre-generated organozinc, Grignard and organoborane species has been used to furnish diverse molecular structures. However, the manipulations required to produce these activated structures is inefficient, leading to poor step- and atom-economies. Moreover, the operational difficulties associated with making and using these reactive coupling partners, and preserving them through a synthetic sequence, has hindered their widespread adoption. A generically useful sp3sp3 coupling technology that uses bench-stable, native organic functional groups, without the need for pre-functionalization or substrate derivatization, would therefore be valuable. Here we demonstrate that the synergistic merger of photoredox and nickel catalysis enables the direct formation of sp3sp3 bonds using only simple carboxylic acids and alkyl halides as the nucleophilic and electrophilic coupling partners, respectively. This metallaphotoredox protocol is suitable for many primary and secondary carboxylic acids. The merit of this coupling strategy is illustrated by the synthesis of the pharmaceutical tirofiban in four steps from commercially available starting materials.

doi: 10.1038/nature19056

Full Text | PDF


An early geodynamo driven by exsolution of mantle components from Earth’s core p.326

Experiments show that magnesium oxide can dissolve in core-forming metallic melts at very high temperatures; core formation models suggest that a giant impact during Earth’s accretion could have contributed large amounts of magnesium to the early core, the subsequent exsolution of which would have generated enough gravitational energy to power an early geodynamo and produce an ancient magnetic field.

doi: 10.1038/nature18594

日本語要約 | Full Text | PDF


Natural courtship song variation caused by an intronic retroelement in an ion channel gene p.329

Natural variation in the courtship song of Drosophila is mapped to the intronic insertion of a retroelement at the slowpoke locus, which encodes an ion channel.

doi: 10.1038/nature19093

日本語要約 | Full Text | PDF


Operation of a homeostatic sleep switch p.333

Sleep-promoting neurons in Drosophila are shown to switch between electrical activity and silence as a function of sleep need; the switch is operated by dopamine and involves the antagonistic regulation of two potassium channels.

doi: 10.1038/nature19055

日本語要約 | Full Text | PDF


A human neurodevelopmental model for Williams syndrome p.338

A human neurodevelopmental model fills the current knowledge gap in the cellular biology of Williams syndrome and could lead to further insights into the molecular mechanism underlying the disorder and the human social brain.

doi: 10.1038/nature19067

日本語要約 | Full Text | PDF


Asymmetric division of contractile domains couples cell positioning and fate specification p.344

Here, a combination of biophysical measurement, modelling, and genetic and experimental manipulation of cell contractile components is used to analyse the formation of the inner cell mass in the early mouse embryo.

doi: 10.1038/nature18958

日本語要約 | Full Text | PDF


HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis p.349

Size-selective pores in the HIV-1 capsid hexamer recruit nucleotides, thereby allowing reverse transcription to take place inside the capsid.

doi: 10.1038/nature19098

日本語要約 | Full Text | PDF


Structure of mammalian respiratory complex I p.354

Electron cryomicroscopy structures are provided for all core and supernumerary protein subunits of mammalian complex I, a 45-subunit enzyme that powers eukaryotic respiration.

doi: 10.1038/nature19095

日本語要約 | Full Text | PDF

「Journal home」に戻る