Gotta name them all: how Pokémon can transform taxonomy p.323

Scientists are urging Pokémon Go fanatics to keep an eye out for new species.

doi: 10.1038/535323b


Reward the forgotten foot soldiers of science p.323

The story of CRISPR–Cas9 gene editing has tended to focus on a few key players. But, as with any area of basic research, it takes a small army of talented researchers to make a discovery.

doi: 10.1038/535323a


Time for physics to make its mark on cycling p.324

Basic bike design has been unchanged for a century — but science is finally finding out how to make bicycles better.

doi: 10.1038/535324a


EU離脱の決まった英国のTheresa May新政権の省庁再編では、科学にも影響が。

Science’s status shifts in new Brexit government p.331

Reshuffled UK administration signals change for research and science policy.

doi: 10.1038/nature.2016.20264


First Greek science agency is rare source of joy for beleaguered researchers p.333

European Investment Bank provides surprise loan to halt startling brain drain.

doi: 10.1038/535333a


South China Sea ruling sparks conservation fears p.334

Court decision escalates tensions in ecologically sensitive region, but may also push nations to cooperate.

doi: 10.1038/535334a


Older men and young women drive South African HIV epidemic p.335

Genetics study confirms social cycle that helps infection to spread.

doi: 10.1038/nature.2016.20273


Science under siege: how Venezuela’s economic crisis is affecting researchers p.336

Chemist Claudio Bifano tells Nature about daily life in a country gripped by hunger, scarcity and violence.

doi: 10.1038/nature.2016.20261


Algae are melting away the Greenland ice sheet p.336

'Black and Bloom' project explores how microorganisms help to determine the pace of Arctic melting.

doi: 10.1038/nature.2016.20265

News Features


The bicycle problem that nearly broke mathematics p.338

自転車を愛し自転車と共に過ごしてきた技術者Jim Papadopoulosの、自転車の走る仕組みに関する数学的研究が、今、注目を集めている。

doi: 10.1038/535338a


The unsung heroes of CRISPR p.342


doi: 10.1038/535342a

News & Views


Climate science: Cooling in the Antarctic p.358


doi: 10.1038/535358a


Molecular biology: A surprise beginning for RNA p.359


doi: 10.1038/nature18908


Conservation: Fishing for lessons on coral reefs p.361


doi: 10.1038/535361a


Condensed-matter physics: Attractive electrons from nanoengineering p.362


doi: 10.1038/535362a


Biogeochemistry: Nocturnal escape route for marsh gas p.363


doi: 10.1038/535363a


Physiology: Pancreatic β-cell heterogeneity revisited p.365


doi: 10.1038/nature18907



A comprehensive transcriptional map of primate brain development p.367

A high-resolution gene expression atlas of prenatal and postnatal brain development of rhesus monkey charts global transcriptional dynamics in relation to brain maturation, while comparative analysis reveals human-specific gene trajectories; candidate risk genes associated with human neurodevelopmental disorders tend to be co-expressed in disease-specific patterns in the developing monkey neocortex.

doi: 10.1038/nature18637


Human gut microbes impact host serum metabolome and insulin sensitivity p.376

Increased potential for branched-chain amino acid and lipopolysaccharide biosynthesis in the gut microbiome of insulin-resistant individuals suggests that changes in the serum metabolome induced by dysbiosis, and driven by only a handful of species, contribute to the development of diabetes.

doi: 10.1038/nature18646


Replication fork stability confers chemoresistance in BRCA-deficient cells p.382

Protection of nascent DNA from degradation provides a mechanism that can promote synthetic viability and drug resistance in Brca-deficient cells without restoring homologous recombination at double-strand breaks.

doi: 10.1038/nature18325



Relativistic reverberation in the accretion flow of a tidal disruption event p.388

Observations of reverberation arising from gravitationally redshifted iron Kα photons reflected off the inner accretion flow in a tidal disruption event demonstrate that X-rays originate from a region very close to the central black hole and not from a relativistic jet, as previously thought.

doi: 10.1038/nature18007


Origin and implications of non-radial Imbrium Sculpture on the Moon p.391

The widespread rimmed grooves, lineations and elongate craters extending from the Imbrium impact basin on the Moon, termed the Imbrium Sculpture, includes a non-radial component that is used to infer that the Imbrium impactor was the size of a proto-planet—about half the diameter of Vesta.

doi: 10.1038/nature18278


Electron attraction mediated by Coulomb repulsion p.395

Experimental demonstration of excitonic attraction between two electrons is achieved in quantum devices made from carbon nanotubes, where the interaction between two electrons is reversed from repulsive to attractive owing to their strong Coulomb interaction with another electronic system.

doi: 10.1038/nature18639


Engineering and mapping nanocavity emission via precision placement of DNA origami p.401

The incorporation of large numbers of chemically diverse functional components into microfabricated structures at precise locations is challenging; now the precision placement of DNA origami by directed self-assembly is shown to overcome this problem for the purpose of reliably and controllably coupling molecular emitters to photonic crystal cavities.

doi: 10.1038/nature18287


Cooperative electrocatalytic alcohol oxidation with electron-proton-transfer mediators p.406

A co-catalyst system for electrochemical alcohol oxidation composed of a bipyridine copper catalyst and an electron-proton-transfer mediator called TEMPO operates at much lower potential and is faster than TEMPO alone.

doi: 10.1038/nature18008


Absence of 21st century warming on Antarctic Peninsula consistent with natural variability p.411

Here it is shown that the late twentieth century warming trends in the Antarctic Peninsula have ceased, with the Peninsula having instead been cooling for most of the twenty-first century, underscoring the considerable internal variability within the Antarctic climate system.

doi: 10.1038/nature18645


Bright spots among the world’s coral reefs p.416

Data from over 2,500 reefs worldwide is used to identify 15 bright spots—sites where reef biomass is significantly higher than expected—and surveys of local experts in these areas suggest that strong sociocultural institutions and high levels of local engagement are among the factors supporting higher fish biomass.

doi: 10.1038/nature18607


Prefrontal neuronal assemblies temporally control fear behaviour p.420

Precise spike timing through the coordination and synchronization of neuronal assemblies is an efficient and flexible coding mechanism for sensory and cognitive processing. In cortical and subcortical areas, the formation of cell assemblies critically depends on neuronal oscillations, which can precisely control the timing of spiking activity. Whereas this form of coding has been described for sensory processing and spatial learning, its role in encoding emotional behaviour remains unknown. Fear behaviour relies on the activation of distributed structures, among which the dorsal medial prefrontal cortex (dmPFC) is known to be critical for fear memory expression. In the dmPFC, the phasic activation of neurons to threat-predicting cues, a spike-rate coding mechanism, correlates with conditioned fear responses and supports the discrimination between aversive and neutral stimuli. However, this mechanism does not account for freezing observed outside stimuli presentations, and the contribution of a general spike-time coding mechanism for freezing in the dmPFC remains to be established. Here we use a combination of single-unit and local field potential recordings along with optogenetic manipulations to show that, in the dmPFC, expression of conditioned fear is causally related to the organization of neurons into functional assemblies. During fear behaviour, the development of 4 Hz oscillations coincides with the activation of assemblies nested in the ascending phase of the oscillation. The selective optogenetic inhibition of dmPFC neurons during the ascending or descending phases of this oscillation blocks and promotes conditioned fear responses, respectively. These results identify a novel phase-specific coding mechanism, which dynamically regulates the development of dmPFC assemblies to control the precise timing of fear responses.

doi: 10.1038/nature18630


Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour p.425

Immune dysfunction is commonly associated with several neurological and mental disorders. Although the mechanisms by which peripheral immunity may influence neuronal function are largely unknown, recent findings implicate meningeal immunity influencing behaviour, such as spatial learning and memory. Here we show that meningeal immunity is also critical for social behaviour; mice deficient in adaptive immunity exhibit social deficits and hyper-connectivity of fronto-cortical brain regions. Associations between rodent transcriptomes from brain and cellular transcriptomes in response to T-cell-derived cytokines suggest a strong interaction between social behaviour and interferon-γ (IFN-γ)-driven responses. Concordantly, we demonstrate that inhibitory neurons respond to IFN-γ and increase GABAergic (γ-aminobutyric-acid) currents in projection neurons, suggesting that IFN-γ is a molecular link between meningeal immunity and neural circuits recruited for social behaviour. Meta-analysis of the transcriptomes of a range of organisms reveals that rodents, fish, and flies elevate IFN-γ/JAK-STAT-dependent gene signatures in a social context, suggesting that the IFN-γ signalling pathway could mediate a co-evolutionary link between social/aggregation behaviour and an efficient anti-pathogen response. This study implicates adaptive immune dysfunction, in particular IFN-γ, in disorders characterized by social dysfunction and suggests a co-evolutionary link between social behaviour and an anti-pathogen immune response driven by IFN-γ signalling.

doi: 10.1038/nature18626


Identification of proliferative and mature β-cells in the islets of Langerhans p.430

Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or dysfunction of β-cells. Pancreatic β-cells differ in size, glucose responsiveness, insulin secretion and precursor cell potential; understanding the mechanisms that underlie this functional heterogeneity might make it possible to develop new regenerative approaches. Here we show that Fltp (also known as Flattop and Cfap126), a Wnt/planar cell polarity (PCP) effector and reporter gene, acts as a marker gene that subdivides endocrine cells into two subpopulations and distinguishes proliferation-competent from mature β-cells with distinct molecular, physiological and ultrastructural features. Genetic lineage tracing revealed that endocrine subpopulations from Fltp-negative and -positive lineages react differently to physiological and pathological changes. The expression of Fltp increases when endocrine cells cluster together to form polarized and mature 3D islet mini-organs. We show that 3D architecture and Wnt/PCP ligands are sufficient to trigger β-cell maturation. By contrast, the Wnt/PCP effector Fltp is not necessary for β-cell development, proliferation or maturation. We conclude that 3D architecture and Wnt/PCP signalling underlie functional β-cell heterogeneity and induce β-cell maturation. The identification of Fltp as a marker for endocrine subpopulations sheds light on the molecular underpinnings of islet cell heterogeneity and plasticity and might enable targeting of endocrine subpopulations for the regeneration of functional β-cell mass in diabetic patients.

doi: 10.1038/nature18624


Mobile genes in the human microbiome are structured from global to individual scales p.435

Mobile genes, which can be transferred between bacterial species in the microbiome to impart properties such as antibiotic resistance, are reflective of human activity and local diets.

doi: 10.1038/nature18927


Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence p.440

Neurotrophic factors produced by enteric glia in response to microbiota and alarmin cues regulate IL-22 production by group 3 innate lymphoid cells in the gut; disruption of this pathway leads to impaired clearance of Citrobacter rodentium and defects in epithelial integrity in a model of intestinal inflammation.

doi: 10.1038/nature18644


The mechanism of RNA 5′ capping with NAD+, NADH and desphospho-CoA p.444

The chemical nature of the 5′ end of RNA is a key determinant of RNA stability, processing, localization and translation efficiency, and has been proposed to provide a layer of ‘epitranscriptomic’ gene regulation. Recently it has been shown that some bacterial RNA species carry a 5′-end structure reminiscent of the 5′ 7-methylguanylate ‘cap’ in eukaryotic RNA. In particular, RNA species containing a 5′-end nicotinamide adenine dinucleotide (NAD+) or 3′-desphospho-coenzyme A (dpCoA) have been identified in both Gram-negative and Gram-positive bacteria. It has been proposed that NAD+, reduced NAD+ (NADH) and dpCoA caps are added to RNA after transcription initiation, in a manner analogous to the addition of 7-methylguanylate caps. Here we show instead that NAD+, NADH and dpCoA are incorporated into RNA during transcription initiation, by serving as non-canonical initiating nucleotides (NCINs) for de novo transcription initiation by cellular RNA polymerase (RNAP). We further show that both bacterial RNAP and eukaryotic RNAP II incorporate NCIN caps, that promoter DNA sequences at and upstream of the transcription start site determine the efficiency of NCIN capping, that NCIN capping occurs in vivo, and that NCIN capping has functional consequences. We report crystal structures of transcription initiation complexes containing NCIN-capped RNA products. Our results define the mechanism and structural basis of NCIN capping, and suggest that NCIN-mediated ‘ab initio capping’ may occur in all organisms.

doi: 10.1038/nature18622


Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation p.448

Stabilization of an active and inactive conformation of the β2-adrenergic receptor by allosteric nanobodies reveals differential ligand-dependent regulation of receptor states to control G-protein-coupled receptor activation.

doi: 10.1038/nature18636

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