Research Highlights

New armour against HIV

doi:10.1038/nindia.2010.40 Published online 31 March 2010

Researchers have synthesised new compounds from natural products that could battle drug-resistant HIV.

They isolated two natural products – buchapine, a quinolone alkaloid from the epigeal part of Haplophyllum bucharicum, H. tuberculatum, and Euodia roxburghiana and another compound from extract of H. tuberculatum and E. roxburghiana.

They synthesised analogues of quinoline 2,4-diol based on the natural products and tested their anti-HIV activity against HIV-1, which causes AIDS, in cultured human lymphoblastoid CEM-SS cells. Buchapine was found to be a potent inhibitor of HIV-1.

Some of the compounds were safer and showed better therapeutic index than AZT, an anti-HIV drug, the researchers say.

The authors of this work are from: Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Punjab and National Centre for Cell Science (NCCS), Pune, Maharashtra, India.


References

  1. Ahmed, N. et al. Synthesis and Anti-HIV Activity of Alkylated Quinoline 2,4-diols. Bioorg. Med. Chem. doi: 10.1016/j.bmc.2010.03.015 (2010)