Smarter therapeutic micro-vessel
doi:10.1038/nindia.2010.17 Published online 22 February 2010
It is not easy for nanoparticles to ferry genes or drugs to the body's many organs. They could face fluid pressure from blood and bump into floating blood cells.
Indian researchers have now devised mathematical models that raise the possibility of designing tiny micro-vessels from embedded magnetic nanoparticles. This will overcome the problems faced by nanoparticles while cruising in the blood vessels and open up new avenues for nanoparticle-based therapy and diagnosis for various diseases.
The researchers say human blood is more suitable for micro-vessels of radius 50 micrometre with embedded magnetic nanoparticles. They also envision the capture of therapeutic magnetic nanoparticles in the human microvasculature for different radii and volume fractions in both the invasive and non-invasive cases.
The findings of the research are significant because macromolecules and nanoparticles are systematically administered and transported within capillaries with different radii, lengths, and properties.
- Shaw, S. et al. Effect of non-Newtonian characteristics of blood on magnetic targeting in the impermeable micro-vessel. J. Magn. Magn. Mater. 322, 1037-1043 (2010) | Article |