Obesity gene not for South Indians
doi:10.1038/nindia.2010.112 Published online 12 August 2010
The neuropeptide Y (NPY) gene previously reported to be associated with obesity has been found not to be linked with the condition in a South India population. The population-specific finding has implications for personal genomics medical applications.
The NPY gene is known to play a critical role in the regulation of satiety, reproduction, central endocrine and cardiovascular systems. Among the primary functions associated with NPY are its acute effects on feeding behaviour and energy expenditure.
The researchers used this knowledge to evaluate the relationship between obesity and NPY gene polymorphisms in 263 individuals from South India. The subjects were divided into two groups based on their body mass index and were then studied using logistic regression, haplotype analysis and linkage disequilibrium.
The study did not reveal significant association of obesity and NPY single-nucleotide polymorphisms. The researchers say this data can be used as a case study for more population-specific genomic studies.