Tiny RBC saviours
doi:10.1038/nindia.2009.364 Published online 11 January 2010
Nanofibres could come to the rescue of red blood cells. Researchers have designed special nanofibres that might protect RBCs against toxic agents generated during physiological anomalies.
RBCs normally live for 120 days. But, some diseases and processes cause their breakdown sooner. To find a way to prevent such abnormal breakdown of RBCs, the researchers invented a nanofibre using polyaniline nanofibres, hydrochloric acid and camphor sulfonic acid.
The study found that adding hydrochloric acid changed the structural conformation exhibiting in absorption phenomenon and reduction of particle size. To check the antioxidant activity of nanofibres, the researchers successfully carried out experiment using 1,1-diphenyl-2-picrylhydrazyl (DPPH), a type of free radical.
It has also been observed that the nanofibres are able to protect haemolysis (breakdown of RBCs) initiated by cytotoxic agents, namely hydrogen peroxide. The increase in antioxidant and haemolysis prevention activity has been attributed to the reduction in particle size and changes in structural conformation, the researchers say.