Nature Hot Topic

A novel route to mouse cancer models

Genome editing tools exploiting the prokaryotic CRISPR/Cas immune system have been successfully applied in many organisms, including mouse and human cells. Here Tyler Jacks and colleagues demonstrate the feasibility of using the CRISPR/Cas system in vivo to induce direct mutation of tumour-suppressor genes and oncogenes in mouse liver. Cancer genes are traditionally studied using genetically engineered mouse models through embryonic stem cell targeting; this work highlights the power of the CRISPR/Cas9 system for rapid genome editing and the development of novel cancer models, as well as for functional genomics studies.

Nature 514, 7522 table of contents

Top Ten Highlights

Sign up for Nature Research e-alerts to get the lastest research in your inbox every week.

More Hot Topics

PrivacyMark System