Nature Hot Topic

Dynamin structure and function

Dynamin is a GTPase that catalyses vesicle scission during clathrin-mediated endocytosis. Two related studies present the crystal structure of dynamin 1, including the GTPase domain, the bundle signalling element, the stalk and the pleckstrin homology domain. Dynamin-related proteins are ubiquitous regulators of membrane shape, and these structures provide insights into the mechanisms of dynamin 1 self-assembly and membrane scission events.

Nature Volume 477 Issue 7366

Top Ten Highlights

Sign up for Nature Research e-alerts to get the lastest research in your inbox every week.

More Hot Topics

PrivacyMark System