Dynamin is a GTPase that catalyses vesicle scission during clathrin-mediated endocytosis. Two related studies present the crystal structure of dynamin 1, including the GTPase domain, the bundle signalling element, the stalk and the pleckstrin homology domain. Dynamin-related proteins are ubiquitous regulators of membrane shape, and these structures provide insights into the mechanisms of dynamin 1 self-assembly and membrane scission events.
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