This issue covers some of the hottest topics in stem-cell research. A News and Views article discusses the discovery that induced pluripotent stem (iPS) cells can be immunogenic. Other research articles identify an immune-privileged site in bone-marrow stem cells; a new pathway for the generation of haematopoietic stem cells; and a replacement iPS-cell inducing transcription factor for the cancer-causing c-Myc. And an article published online has identified a peptide that can stimulate progenitor cells to act as a source of new cardiomyocytes.
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