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Neuronal regulation of a humoral immune response

In this study, the authors demonstrate that neuronal signalling initiated in the brain projects to the spleen and induces the release of norepinephrine and acetylcholine, which promote plasma cell formation and antibody production during a T cell-dependent B cell response. This work reveals that the brain can control adaptive immunity via a direct neural connection, in addition to the long-known neuroendocrine route.

Nature Volume 581 Issue 7807

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