Nature Hot Topic

Adding a ‘magic’ methyl

The ‘magic’ methyl effect is a well-known chemistry idiom, describing the big effect that a single CH3 group can have on the bioactivity or selectivity of a molecule. However, it is currently tricky to simply stick a methyl onto an existing drug or natural product. Here, M. Christina White and colleagues report a Mn-catalysed oxidative C(sp3)–H methylation method that can install a methyl into various medicinally important heterocycles with high site-selectivity. This allows the modification of various natural products and drugs in a single step, providing the basis on which to better understand the ‘magic’ methyl effect and improve both current and new pharmaceutical agents.

Nature Volume 580 Issue 7805

Top Ten Highlights

Sign up for Nature Research e-alerts to get the lastest research in your inbox every week.

More Hot Topics

PrivacyMark System