Nearly half of all deafness cases arise from genetic factors, yet there are limited treatment options available for inherited hearing loss. David Liu and colleagues develop a genome-editing approach to target a dominantly inherited form of deafness. In a mouse model of human deafness, CRISPR–Cas9 editing can disrupt the mutant allele and reduce hearing loss. The results support the potential utility of protein–RNA complex delivery in post-mitotic cells as a gene-editing strategy for some autosomal-dominant diseases.
- Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents (Letter p217, doi: 10.1038/nature25164)
- An ode to gene edits that prevent deafness (News & Views p162, doi: 10.1038/d41586-017-08645-z)
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