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Hypothalamus controls the speed of ageing

Dongsheng Cai and colleagues previously showed that the hypothalamus has a critical role in systemic ageing. Here they observe a substantial loss of hypothalamic stem cells in middle-aged mice. They show in several mouse models that ablation of these cells results in ageing-like physiological changes and a shortened lifespan. Conversely, ageing could be slowed and lifespan extended by transplantation of healthy hypothalamic stem cells into middle aged mice. Hypothalamic stem cells secrete exosomal miRNAs, contributing to a pool of circulating miRNAs in the cerebrospinal fluid that declines with age. These secreted exosomes contribute, at least in part, to a deceleration of ageing. The authors conclude that the speed of ageing is partially controlled by hypothalamic stem cells and their exosomal miRNAs in the cerebrospinal fluid.

Nature Volume 548 Issue 7665

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