Research highlight

Variants associated with tuberculosis

Nature Genetics

August 9, 2010

Genetic variants associated with tuberculosis susceptibility are reported this week in Nature Genetics. This represents one of the few genome-wide association studies in African populations to convincingly identify genetic variants associated with susceptibility to an infectious disease.

Tuberculosis has an estimated global annual incidence of 9 million, and 1.3 million deaths are attributed to active disease. The highest burden of disease is found in developing countries of Africa and South-East Asia.

Adrian Hill and colleagues report a genome-wide association for pulmonary tuberculosis, in a combined group of 11,425 individuals from Ghana and The Gambia. They identify a single genomic region associated with progression to disease.

doi: 10.1038/ng.639

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