Research highlight

Variants associated with diabetes

Nature Genetics

December 12, 2011

Genetic variants associated with type 2 diabetes in East Asian populations are reported this week in Nature Genetics. Yoon Shin Cho and colleagues report a meta-analysis of eight genome-wide association studies for type 2 diabetes including 6,952 cases and 11,865 controls from East Asian populations, with two further stages of replication including over 18,000 cases. They identify eight genomic regions newly associated with susceptibility to type 2 diabetes. This provides comparisons to previous studies in European ancestry populations, and suggests both shared and distinct genetic pathways are involved in susceptibility to T2D in East Asians populations.

doi: 10.1038/ng.1019

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