Combining two types of immunotherapy — immune-checkpoint inhibition and adoptive cell therapy using tumor-infiltrating lymphocytes — elicits anti-tumor responses in patients with metastatic lung cancer, according to a paper published in Nature Medicine. These proof-of-concept data (involving 20 participants) may offer a new treatment approach for patients with advanced lung cancer.
Immune-checkpoint inhibition — a type of immunotherapy in which drugs are administered to inhibit protein regulators of the immune system — produces clinical responses in only a subset of patients with cancer. Recently, there has been increasing interest in the use of autologous tumor-infiltrating lymphocytes (TILs) as a therapeutic approach for cancer treatment, notably in the case of breast and melanoma skin cancers. This strategy involves harvesting immune cells called ‘T cells’ from a patient’s tumors, co-culturing them in the laboratory with tumor cells, expanding those that exhibit reactivity against cancer cells, and re-introducing them into patients.
Benjamin Creelan and colleagues conducted a phase 1 clinical trial investigating how immune-checkpoint inhibition therapy using the drug nivolumab could be combined with the TILs to treat metastatic lung cancer in a cohort of 20 patients. Within a few weeks of treatment, several patients were found to display signs of clinical activity, with two patients achieving remission of their tumors. By conducting a molecular analysis of TILs and genetically sequencing tumor biopsies, the authors confirmed that the responses observed in most patients were associated with TILs’ recognizing antigens expressed by tumor cells. In some cases, TILs specific to these antigens maintained their anti-tumor activity for over a year. Not only did the combination of TILs with nivolumab display promising efficacy, but it was also considered safe, with manageable adverse effects.
Although this pilot trial was performed with a small number of patients, the authors conclude that this combinative therapy might constitute a promising new treatment strategy for advanced forms of this disease.
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