The myelin fix
Nature Medicine
July 4, 2011
The upregulation of the death receptor 6 (DR6), in the brain could be inhibiting brain repair in patients with multiple sclerosis (MS). These results, published online this week in Nature Medicine, could potentially lead to new a therapeutic approach for multiple sclerosis.In multiple sclerosis, patients exhibit massive demyelination—where the protective layer on axons is damaged—which is one of the reasons for the neurological dysfunction that characterizes the disease. Sha Mi and colleagues found that DR6 was upregulated in brain tissue from those who suffered from MS. The authors found similar results in a rat model of the disease. They believe that DR6 seems to act by killing off immature oligodendrocytes—support cells in the brain—that could otherwise repair the damaged myelin. By using antibodies to block DR6 in the rat model of MS, they find that oligodendrocytes could repair the myelin and ameliorate neurological dysfunction.
doi: 10.1038/nm.2373
Research highlights
-
Aug 5
Microbiology: Single switch makes Escherichia coli beneficial insect partnerNature Microbiology
-
Aug 5
Conservation: More than half of unassessable species may be at risk of extinctionCommunications Biology
-
Aug 4
Physiology: Restoring cellular functions in pigs after deathNature
-
Aug 3
Zoology: Mother’s iron helps Weddell seal pups diveNature Communications
-
Aug 2
Health: Certain medications may impact risk of heat-related heart attacksNature Cardiovascular Research
-
Jul 28
Archaeology: Ancient humans were consuming milk long before they could digest itNature