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NATURE COMMUNICATIONS 每周内容提示
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| 2015年3月13日 |
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了解NPG亚太地区的最新出版动态 |
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《2014自然指数中国增刊》
本增刊介绍了中国主要科研机构和大学对全球科学发展的贡献、科研产出领先的十大城市，以及中国与其它国家的科研论文合作情况。 | | |
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最新論文 |
View all Articles（英语） |
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STAT3信号作用的破坏促进由KRAS诱导的肺肿瘤发生 OPEN |
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Beatrice Grabner, Daniel Schramek, Kristina M. Mueller, Herwig P. Moll, Jasmin Svinka, Thomas Hoffmann, Eva Bauer, Leander Blaas, Natascha Hruschka, Katalin Zboray, Patricia Stiedl, Harini Nivarthi, Edith Bogner, Wolfgang Gruber, Thomas Mohr, Ralf Harun Zwick, Lukas Kenner, Valeria Poli, Fritz Aberger, Dagmar Stoiber et al.
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| STAT3 is an intracellular transducer of cytokine signals that cooperates with Ras in tumour formation and is often activated in lung cancer. Here the authors show that STAT3 acts as a tumour suppressor in a mouse model of Kras-driven lung adenocarcinoma. |
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| 03 March 2015 | doi: 10.1038/ncomms7285 |
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Biological Sciences
Cancer
Molecular biology
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| 一种金属富勒烯的分子磁开关 OPEN |
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Bo Wu, Taishan Wang, Yongqiang Feng, Zhuxia Zhang, Li Jiang and Chunru Wang
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| Endohedral fullerenes are known to stabilize reactive radicals; however, the external magnetic manipulation of these species’ remains challenging. Here, the authors link a nitroxide radical to a paramagnetic fullerene system and are able to alter the spin behaviour of the fullerene via spin–spin interactions. |
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| 03 March 2015 | doi: 10.1038/ncomms7468 |
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Chemical Sciences
Inorganic chemistry
Nanotechnology
Physical chemistry
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| 用于超灵敏压力检测的柔性悬浮门有机薄膜晶体管 OPEN |
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Yaping Zang, Fengjiao Zhang, Dazhen Huang, Xike Gao, Chong-an Di and Daoben Zhu
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| The development of wearable healthcare and intelligence systems require low-cost, large-area flexible electronic sensors. Here, Zang et al. report pressure sensors based on organic thin-film transistors in combination with a suspended-gate device geometry, which show high sensitivity up to 192 kPa−1. |
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| 03 March 2015 | doi: 10.1038/ncomms7269 |
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Physical Sciences
Applied physics
Materials science
Nanotechnology
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| 具有两个堆叠漩涡的纳米振荡器内在细分裂频率上由自旋力矩诱导的动态 |
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V. Sluka, A. Kákay, A. M. Deac, D. E. Bürgler, C. M. Schneider and R. Hertel
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| Magnetic vortices in nanodiscs possess potential applications based on their magnetic configuration and spin-torque-driven oscillation. Here, Sluka et al. show how the coupled gyration of two stacked vortices is split into discretized frequencies defined by their relative chirality and polarity. |
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| 03 March 2015 | doi: 10.1038/ncomms7409 |
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Physical Sciences
Condensed matter
Nanotechnology
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| 三维互连纳米颗粒超晶格的制备及它们的锂离子存储性能 OPEN |
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Yucong Jiao, Dandan Han, Yi Ding, Xianfeng Zhang, Guannan Guo, Jianhua Hu, Dong Yang and Angang Dong
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| Three-dimensional nanoparticle superlattices are interesting, but their fabrication is generally limited to materials attainable as monodisperse colloidal nanoparticles. Here, the authors fabricate interconnected superlattices via self-assembly without the presynthesis of the constituent nanoparticles. |
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| 03 March 2015 | doi: 10.1038/ncomms7420 |
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Chemical Sciences
Inorganic chemistry
Materials science
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| 一种固体密度的铝等离子体中的飞秒碰撞电离率研究 |
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S. M. Vinko, O. Ciricosta, T. R. Preston, D. S. Rackstraw, C.R.D. Brown, T. Burian, J. Chalupský, B. I. Cho, H.-K. Chung, K. Engelhorn, R. W. Falcone, R. Fiokovinini, V. Hájková, P. A. Heimann, L. Juha, H. J. Lee, R. W. Lee, M. Messerschmidt, B. Nagler, W. Schlotter et al.
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| The electrons in a plasma can further ionize the ions when the two collide. Vinko et al. now study this ultrafast process in an unconventional plasma with a density similar to that of a solid, and show that the rate is several times higher than that predicted by standard theoretical models. |
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| 03 March 2015 | doi: 10.1038/ncomms7397 |
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Physical Sciences
Fluids and plasma physics
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| 四层石墨烯中的绝缘态显示了多层石墨烯中存在一种奇-偶相互作用效应 OPEN |
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Anya L. Grushina, Dong-Keun Ki, Mikito Koshino, Aurelien A. L. Nicolet, Clément Faugeras, Edward McCann, Marek Potemski and Alberto F. Morpurgo
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| Electron–electron interactions have a strong influence on the properties of bilayer graphene, but less of an effect on trilayer material. Grushina et al. show that tetralayer graphene has an insulator state, bucking the trend for electron–electron interactions becoming weaker with more layers. |
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| 03 March 2015 | doi: 10.1038/ncomms7419 |
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Physical Sciences
Condensed matter
Materials science
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| FAAH基因变异能增强小鼠和人类的fronto-amygdala功能 |
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Iva Dincheva, Andrew T. Drysdale, Catherine A. Hartley, David C. Johnson, Deqiang Jing, Elizabeth C. King, Stephen Ra, J. Megan Gray, Ruirong Yang, Ann Marie DeGruccio, Chienchun Huang, Benjamin F. Cravatt, Charles E. Glatt, Matthew N. Hill, B. J. Casey and Francis S. Lee
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| Fatty acid amide hydrolase (FAAH) is a key regulator of endocannabinoid signalling. Here, the authors develop a knock-in mouse that recapitulates a common human mutation in the FAAH gene and demonstrate parallel neural and behavioural alterations across species, suggesting a gain-of-function in fear regulation. |
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| 03 March 2015 | doi: 10.1038/ncomms7395 |
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Biological Sciences
Molecular biology
Neuroscience
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| 超净石墨烯p–n结中的"蛇迹" OPEN |
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Peter Rickhaus, Péter Makk, Ming-Hao Liu, Endre Tóvári, Markus Weiss, Romain Maurand, Klaus Richter and Christian Schönenberger
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| Snake states describe electron trajectories that curve along an interface where the charge is inverted. Here, the authors investigate electronic transport in a ballistic graphene p–n junction and observe striking conductance oscillations that are a signature of these unusual states. |
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| 03 March 2015 | doi: 10.1038/ncomms7470 |
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Physical Sciences
Applied physics
Materials science
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| 一种"升华热"热力发动机 OPEN |
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Gary G. Wells, Rodrigo Ledesma-Aguilar, Glen McHale and Khellil Sefiane
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| Heat engines are designed to convert thermal energy into mechanical work through a thermodynamic cycle. Here, Wells et al. show a cycle based on a sublimation process, where a disk of dry ice that rotates on a hot surface due to the Leidenfrost effect is coupled to a simple electromagnetic generator. |
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| 03 March 2015 | doi: 10.1038/ncomms7390 |
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Physical Sciences
Applied physics
Fluids and plasma physics
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| 过渡金属离子平衡的失控是镉在肺炎链球菌中产生毒性的分子基础 OPEN |
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Stephanie L. Begg, Bart A. Eijkelkamp, Zhenyao Luo, Rafael M. Couñago, Jacqueline R. Morey, Megan J. Maher, Cheryl-lynn Y. Ong, Alastair G. McEwan, Bostjan Kobe, Megan L. O’Mara, James C. Paton and Christopher A. McDevitt
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| The molecular basis for the high toxicity of cadmium is unclear. Here, Begg et al. use the bacterium Streptococcus pneumoniae as a model system, and show that cadmium uptake increases sensitivity to oxidative stress by reducing intracellular concentrations of manganese and zinc through different mechanisms. |
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| 03 March 2015 | doi: 10.1038/ncomms7418 |
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Biological Sciences
Biochemistry
Chemical biology
Microbiology
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| 单分子电连接中干涉效应的一个量子回路规则 |
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David Zsolt Manrique, Cancan Huang, Masoud Baghernejad, Xiaotao Zhao, Oday A. Al-Owaedi, Hatef Sadeghi, Veerabhadrarao Kaliginedi, Wenjing Hong, Murat Gulcur, Thomas Wandlowski, Martin R. Bryce and Colin J. Lambert
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| Quantum interference influences charge transport in molecules that include an aromatic ring. Here, the authors develop a quantum circuit rule for understanding such effects in molecules with three aromatic rings and show that their electronic properties are dominated by interference in the central ring. |
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| 03 March 2015 | doi: 10.1038/ncomms7389 |
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Chemical Sciences
Materials science
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| 通过飞秒X-射线脉冲对光诱导的分子内电子转移的非平衡动态进行可视化研究 OPEN |
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Sophie E. Canton, Kasper S. Kjær, György Vankó, Tim B. van Driel, Shin-ichi Adachi, Amélie Bordage, Christian Bressler, Pavel Chabera, Morten Christensen, Asmus O. Dohn, Andreas Galler, Wojciech Gawelda, David Gosztola, Kristoffer Haldrup, Tobias Harlang, Yizhu Liu, Klaus B. Møller, Zoltán Németh, Shunsuke Nozawa, Mátyás Pápai et al.
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| Photoinduced electron transfer in solvated molecular assemblies occurs on the ultrafast timescale before full electronic and geometric relaxation take place. Here Canton et al. monitor this out-of-equilibrium process in a donor–acceptor bimetallic assembly using an X-ray free-electron laser. |
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| 02 March 2015 | doi: 10.1038/ncomms7359 |
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Chemical Sciences
Catalysis
Condensed matter
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| 溶酶体磷脂酶A2(LPLA2)和卵磷脂:胆固醇酰基转移酶(LCAT)的结构和功能 |
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Alisa Glukhova, Vania Hinkovska-Galcheva, Robert Kelly, Akira Abe, James A. Shayman and John J. G. Tesmer
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| Lysosomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT) are important lipid metabolizing enzymes. Here the authors present crystal structures of LPLA2 and LCAT that reveal the unique architecture of this small family of enzymes involved in human physiology and disease. |
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| 02 March 2015 | doi: 10.1038/ncomms7250 |
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Biological Sciences
Biochemistry
Biophysics
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| 控制一个分子二极管中的整流方向 |
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Li Yuan, Nisachol Nerngchamnong, Liang Cao, Hicham Hamoudi, Enrique del Barco, Max Roemer, Ravi K. Sriramula, Damien Thompson and Christian A. Nijhuis
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| The electronic coupling between the active components and electrodes in molecular electronics determines the device performance. Here, Yuan et al. show that a non-covalent coupling is sufficiently strong to induce molecular-based rectification, while weak enough to minimize leakage current. |
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| 02 March 2015 | doi: 10.1038/ncomms7324 |
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Physical Sciences
Materials science
Nanotechnology
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| 一个等离子激元近场的量子化和干涉模式的同时观察 OPEN |
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L Piazza, T.T.A. Lummen, E Quiñonez, Y Murooka, B.W. Reed, B Barwick and F Carbone
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| Mapping the field of surface plasmon polaritons is important to understand their fundamental properties and behaviour. Here, the authors show that ultrafast transmission electron microscopy can simultaneously obtain the spatial interference and quantization of nanowire-confined plasmonic fields. |
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| 02 March 2015 | doi: 10.1038/ncomms7407 |
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Physical Sciences
Nanotechnology
Optical physics
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| 用于太赫表面等离子激元器件的自偏压可重构石墨烯堆栈 |
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J.S. Gomez-Diaz, C Moldovan, S Capdevila, J Romeu, L.S. Bernard, A Magrez, A.M. Ionescu and J Perruisseau-Carrier
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| The unusual electronic and optical properties of graphene are finding increasing applications for terahertz and mid-infrared plasmonics. Here, the authors show how monolayers of graphene separated by thin dielectric layers can act as tunable structures for plasmonic device platforms. |
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| 02 March 2015 | doi: 10.1038/ncomms7334 |
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Physical Sciences
Applied physics
Nanotechnology
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| 在具有高析氢活性的单层氢氧化镍上生长出的超细铂纳米线 |
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Huajie Yin, Shenlong Zhao, Kun Zhao, Abdul Muqsit, Hongjie Tang, Lin Chang, Huijun Zhao, Yan Gao and Zhiyong Tang
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| There is extensive interest in the design of efficient electrocatalysts for hydrogen evolution. Here, the authors show that exfoliated single-layer nickel hydroxide can be used for the controllable surface growth of platinum nanowires, and evaluate the electrocatalytic performance of the composite material. |
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| 02 March 2015 | doi: 10.1038/ncomms7430 |
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Chemical Sciences
Materials science
Physical chemistry
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| IL-10在感染早期抑制由神经氨酸酶激活的TGF-β并促进Th1表现型 |
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Avijit Dutta, Ching-Tai Huang, Tse-Ching Chen, Chun-Yen Lin, Cheng-Hsun Chiu, Yung-Chang Lin, Chia-Shiang Chang and Yueh-Chia He
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| The role of IL-10 in influenza infection is controversial. Here the authors show that early during infection, IL-10 promotes Th1 immunity by inhibiting viral neuraminidase-mediated release of TGF-β, but later acts as an immunosuppressive cytokine to inhibit immunopathology and promote recovery. |
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| 02 March 2015 | doi: 10.1038/ncomms7374 |
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Biological Sciences
Immunology
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| 约束纳米空间中的甲烷水合物形成能超过自然界 |
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Mirian E. Casco, Joaquín Silvestre-Albero, Anibal J. Ramírez-Cuesta, Fernando Rey, Jose L. Jordá, Atul Bansode, Atsushi Urakawa, Inma Peral, Manuel Martínez-Escandell, Katsumi Kaneko and Francisco Rodríguez-Reinoso
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| Methane hydrates may be one of the largest sources of hydrocarbons on Earth, although demanding temperature–pressure conditions are required for their formation. Here the authors exploit the confinement effects on nanopores to rapidly and reversibly produce methane hydrates under mild conditions. |
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| 02 March 2015 | doi: 10.1038/ncomms7432 |
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Chemical Sciences
Inorganic chemistry
Materials science
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| AtNIGT1/HRS1在拟南芥根尖上对硝酸盐信号和磷酸盐信号进行整合 |
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Anna Medici, Amy Marshall-Colon, Elsa Ronzier, Wojciech Szponarski, Rongchen Wang, Alain Gojon, Nigel M. Crawford, Sandrine Ruffel, Gloria M. Coruzzi and Gabriel Krouk
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| Nitrogen and phosphorous are both major macronutrients and important signalling molecules that regulate plant growth. Here, Medici et al. show that nitrogen and phosphorous signals converge at the HRS1 transcription factor to regulate the root elongation in response to nutrient deficiency. |
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| 27 February 2015 | doi: 10.1038/ncomms7274 |
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Biological Sciences
Plant sciences
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| 边缘位错会通过带电缺陷的分离减慢掺杂的CeO2 中的氧化物离子扩散 |
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Lixin Sun, Dario Marrocchelli and Bilge Yildiz
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| Electrochemical devices based on oxide materials, such as batteries or fuel cells, rely on the transport of ions through the crystal lattice. Here, the authors model ion diffusion through CeO2 and observe that edge dislocations slow down ion diffusion, contrary to similar processes in metals. |
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| 27 February 2015 | doi: 10.1038/ncomms7294 |
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Physical Sciences
Materials science Physical
chemistry
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| 高山洞穴堆积物所记录的末次盛冰期北大西洋风暴轨迹变化 OPEN |
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| Marc Luetscher, R. Boch, H.
Sodemann, C. Spötl, H. Cheng, R. L. Edwards, S.
Frisia, F. Hof and W. Müller |
|
| Insights into Late-Pleistocene Northern
Hemisphere storm track variability are hampered by
a lack of well-dated proxy records. Here, the
authors present a precisely dated record of
meteoric precipitation between 30 and 14.7 ka, and
show that obliquity may have played a vital role
in Alpine glacier advance. |
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| 27 February 2015 | doi:
10.1038/ncomms7344 |
|
| Earth
Sciences Atmospheric
science |
| 胆固醇运输物ABCG1将胆固醇平衡与肿瘤免疫联系了起来 |
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| Duygu Sag, Caglar Cekic,
Runpei Wu, Joel Linden and Catherine C. Hedrick
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| ABCG1 transporter pumps cholesterol out
of the cell. Here, the authors show that
ABCG1-deficient mice have reduced tumour growth
due to a switch of the tumour-associated
macrophages from a tumour-promoting to
tumour-suppressing phenotype, and are protected
from the pro-tumorigenic effects of a Western-like
diet. |
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| 27 February 2015 | doi:
10.1038/ncomms7354 |
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| Biological
Sciences Cancer Immunology
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| 细胞免疫记忆和B-细胞免疫的产生因自然杀手细胞而受到影响 |
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| Carolyn Rydyznski, Keith A.
Daniels, Erik P. Karmele, Taylor R. Brooks, Sarah
E. Mahl, Michael T. Moran, Caimei Li, Rujapak
Sutiwisesak, Raymond M. Welsh and Stephen N.
Waggoner |
|
| The need to develop vaccines against
pathogens such as HIV requires the development of
strategies to overcome inhibitory immunoregulatory
mechanisms. Here, the authors report that murine
natural killer cells inhibit CD4- and follicular
helper T cells, leading to a weaker germinal
center response and diminished virus-specific
immune memory. |
|
| 27 February 2015 | doi:
10.1038/ncomms7375 |
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| 来自脑脊液的Semaphorin3B将神经上皮细胞分裂的取向控制在"顶端-基底"轴心方向上 |
|
| Elise Arbeille, Florie
Reynaud, Isabelle Sanyas, Muriel Bozon, Karine
Kindbeiter, Frédéric Causeret, Alessandra Pierani,
Julien Falk, Frédéric Moret and Valérie Castellani
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| The spatial orientation of cell divisions
is fundamental for tissue architecture and
homeostasis but the extracellular cues regulating
this process are largely unknown. Here, the
authors show that Semaphorin3B released from the
floor plate and the nascent choroid plexus
controls progenitor division orientation in the
developing mouse spinal cord. |
|
| 27 February 2015 | doi:
10.1038/ncomms7366 |
|
| Biological
Sciences Developmental
biology Neuroscience
|
| 检查点对于导致染色体总体重排的复制重启和重组中间体"视而不见" OPEN |
|
| Saed Mohebi, Ken’Ichi Mizuno,
Adam Watson, Antony M. Carr and Johanne M. Murray
|
|
| Homologous recombination can overcome
replication fork inactivation, but this can cause
gross chromosomal rearrangements. Here, the
authors show that DNA damage and intra-S phase
checkpoints are blind to chromosome rearrangement
in the first cell cycle, and are only induced in
the second cell cycle. |
|
| 27 February 2015 | doi:
10.1038/ncomms7357 |
|
| Biological
Sciences Cell biology
Molecular
biology |
| 光脉冲序列利用单一碳纳米管的门控生成 OPEN |
|
| M Jiang, Y Kumamoto, A Ishii,
M Yoshida, T Shimada and Y. K. Kato
|
|
| The photocurrent and luminescence of
carbon nanotubes is governed by excitonic
processes with diverse uses in nano-photonics.
Here, Jiang et al.
generate optical pulses from individual
air-suspended carbon nanotubes under an
application of square-wave gate voltages with
control over pulse timing and
duration. |
|
| 27 February 2015 | doi:
10.1038/ncomms7335 |
|
| Physical
Sciences Applied
physics Nanotechnology
Optical
physics |
| 拟南芥MSH1突变改变表观基因组并在植物生长上造成可遗传的变化 OPEN |
|
| Kamaldeep S. Virdi, John D.
Laurie, Ying-Zhi Xu, Jiantao Yu, Mon-Ray Shao,
Robersy Sanchez, Hardik Kundariya, Dong Wang,
Jean-Jack M. Riethoven, Yashitola Wamboldt, Maria
P. Arrieta-Montiel, Vikas Shedge and Sally A.
Mackenzie |
|
| Suppression of MutS HOMOLOGUE 1 (MSH1), a
plant protein targeted to mitochondria and
plastids, causes a variety of phenotypes. Here
Virdi et al. show that
MSH1 depletion in Arabidopsis results in
heritable changes in nuclear DNA methylation,
which can lead to enhanced growth
vigour. |
|
| 27 February 2015 | doi:
10.1038/ncomms7386 |
|
| Biological
Sciences Plant
sciences |
| 通过有机光电二极管的内部量子效率操纵实现窄带光检测 |
|
| Ardalan Armin, Ross D.
Jansen-van Vuuren, Nikos Kopidakis, Paul L. Burn
and Paul Meredith |
|
| There is a growing interest in the
development of narrowband photodiodes for
full-color imaging and visible-blind near-infrared
detection. Armin et al.
show a sub-100 nm response by tuning the spectral
bandwidth through regulating the charge collection
efficiency in a thick organic bulk
heterojunction. |
|
| 27 February 2015 | doi:
10.1038/ncomms7343 |
|
| Physical
Sciences Applied
physics Nanotechnology
Optical
physics |
| 重现性逆转录病毒插入的3D热点显示了与癌症基因的长程相互作用 OPEN |
|
| Sepideh Babaei, Waseem Akhtar,
Johann de Jong, Marcel Reinders and Jeroen de
Ridder |
|
| Retroviral insertional mutagenesis is
used for identifying genes involved in the
development of cancer. Here, the authors overlay
cancer-causing insertions with genome-wide Hi-C
data and find that retroviral elements tend to
cluster in 3D hotspots. |
|
| 27 February 2015 | doi:
10.1038/ncomms7381 |
|
| Biological
Sciences Cancer Genetics
|
| Semaphorin7A调控"下丘脑中突"中的神经胶质可塑性 OPEN |
|
| Jyoti Parkash, Andrea Messina,
Fanny Langlet, Irene Cimino, Anne Loyens, Danièle
Mazur, Sarah Gallet, Eglantine Balland, Samuel A.
Malone, François Pralong, Gabriella Cagnoni,
Roberta Schellino, Silvia De Marchis, Massimiliano
Mazzone, R. Jeroen Pasterkamp, Luca Tamagnone,
Vincent Prevot and Paolo Giacobini
|
|
| Reproduction in mammals is dependent on
the function of specific neurons that secrete
gonadotropin-releasing hormone (GnRH) and project
their axons to the median eminence (ME) of the
hypothalamus. Here the authors show that
Semaphorin7A signaling plays a role in mediating
the plasticity of GnRH axon terminals and
tanycytes in the ME. |
|
| 27 February 2015 | doi:
10.1038/ncomms7385 |
|
| Biological
Sciences Developmental
biology Neuroscience
|
| 地下水中多样化的未曾培养过的超小细菌细胞 |
|
| Birgit Luef, Kyle R.
Frischkorn, Kelly C. Wrighton, Hoi-Ying N. Holman,
Giovanni Birarda, Brian C. Thomas, Andrea Singh,
Kenneth H. Williams, Cristina E. Siegerist,
Susannah G. Tringe, Kenneth H. Downing, Luis R.
Comolli and Jillian F. Banfield
|
|
| Little is known about certain bacterial
phyla because of our current inability to grow
them in the lab. Here, Luef et al. combine
metagenomics and ultrastuctural analyses to show
that some of these bacteria have a very small cell
size, tightly packed DNA, few ribosomes and
diverse pili-like structures. |
|
| 27 February 2015 | doi:
10.1038/ncomms7372 |
|
| Biological
Sciences Cell biology
Ecology Microbiology
|
| 利用一个能够捕捉到肿瘤异质性的体外平台来预测对抗癌药物的临床反应 OPEN |
|
| Biswanath Majumder,
Ulaganathan Baraneedharan, Saravanan Thiyagarajan,
Padhma Radhakrishnan, Harikrishna Narasimhan,
Muthu Dhandapani, Nilesh Brijwani, Dency D. Pinto,
Arun Prasath, Basavaraja U. Shanthappa, Allen
Thayakumar, Rajagopalan Surendran, Govind K. Babu,
Ashok M. Shenoy, Moni A. Kuriakose, Guillaume
Bergthold, Peleg Horowitz, Massimo Loda, Rameen
Beroukhim, Shivani Agarwal et al.
|
|
| Efficacy of anticancer treatments vary
across patients, imposing a need for personalized
approaches. Here the authors show that
responsiveness to chemotherapy can be predicted
using tumour explant cultures in a patient-matched
microenvironment, coupled with a machine-learning
algorithm. |
|
| 27 February 2015 | doi:
10.1038/ncomms7169 |
|
| Biological
Sciences Biotechnology
Cancer Medical
research |
| NCA钠泄漏通道是维持运动的持久运动回路活性所必需的 |
|
| Shangbang Gao, Lin Xie, Taizo
Kawano, Michelle D. Po, Sihui Guan and Mei Zhen
|
|
| Persistent neural activity underlies
working memories and behaviors that require
short-term information retention; the mechanisms
enabling this, however, are unclear. Here the
authors show that the NCA Na+ leak channel is
required for the persistent motor circuit activity
that sustains locomotion in C. elegans. |
|
| 26 February 2015 | doi:
10.1038/ncomms7323 |
|
| Biological
Sciences Neuroscience
|
| 长程表观遗传调控是由位于数千个独立位点上的遗传变异赋予的 OPEN |
|
| Mathieu Lemire, Syed H.E.
Zaidi, Maria Ban, Bing Ge, Dylan Aïssi, Marine
Germain, Irfahan Kassam, Mike Wang, Brent W.
Zanke, France Gagnon, Pierre-Emmanuel Morange,
David-Alexandre Trégouët, Philip S. Wells, Stephen
Sawcer, Steven Gallinger, Tomi Pastinen and Thomas
J. Hudson |
|
| There is a functional link between SNPs
and epigenetic variations when they are in close
range, but the long-range effect is unclear. Here,
by analysing methylation quantitative trait loci,
the authors demonstrate that methylation levels at
CpG sites in lymphocytes are correlated with
distal SNPs. |
|
| 26 February 2015 | doi:
10.1038/ncomms7326 |
|
| Biological
Sciences Genetics Molecular
biology |
| 内壁上有蛋白和脂质的一个溶细胞小孔的自组装的结构基础 OPEN |
|
| Koji Tanaka, Jose M.M.
Caaveiro, Koldo Morante, Juan Manuel
González-Mañas and Kouhei Tsumoto
|
|
| Actinoporins are water-soluble
pore-forming toxins that self-assemble in the
membranes of target cells. Here, the authors
provide insight into the mechanism of membrane
pore formation by solving the structures of
several states of the hemolytic protein
fragaceatoxin C, including the fully assembled
pore. |
|
| 26 February 2015 | doi:
10.1038/ncomms7337 |
|
| Biological
Sciences Biochemistry
Biophysics
|
| 蓝光帽贝的半透明壳中的一个非常明显的、已经矿化的复合光子结构 OPEN |
|
| Ling Li, Stefan Kolle, James
C. Weaver, Christine Ortiz, Joanna Aizenberg and
Mathias Kolle |
|
| Mollusks have evolved an exquisite
diversity of complex mineralized shells for
protection. One such example, the blue-rayed
limpet, incorporates a vivid display of blue
lines, which originate from the interference of
light in a nano-periodic photonic architecture
buried within the animal's translucent
shell. |
|
| 26 February 2015 | doi:
10.1038/ncomms7322 |
|
| Physical
Sciences Bioengineering
Materials
science Optical
physics |
| β-catenin信号作用由"Complement C1q"诱导的激发造成高血压型动脉重塑 OPEN |
|
| Tomokazu Sumida, Atsuhiko T.
Naito, Seitaro Nomura, Akito Nakagawa, Tomoaki
Higo, Akihito Hashimoto, Katsuki Okada, Taku
Sakai, Masamichi Ito, Toshihiro Yamaguchi, Toru
Oka, Hiroshi Akazawa, Jong-Kook Lee, Tohru
Minamino, Stefan Offermanns, Tetsuo Noda, Marina
Botto, Yoshio Kobayashi, Hiroyuki Morita, Ichiro
Manabe et al.
|
|
| The role of macrophages in
hypertension-induced arterial remodeling is poorly
understood. Here, Sumida et
al. show that high blood pressure drives the
alternatively activated macrophages to secrete
complement C1q protein, which in turn elicits
proliferative β-catenin signalling in the arterial
smooth muscle cells. |
|
| 26 February 2015 | doi:
10.1038/ncomms7241 |
|
| Biological
Sciences Immunology Medical
research |
| 用于下一代锂离子电池的稳定硅离子液体界面 |
|
| Daniela Molina Piper, Tyler
Evans, Kevin Leung, Tylan Watkins, Jarred Olson,
Seul Cham Kim, Sang Sub Han, Vinay Bhat, Kyu Hwan
Oh, Daniel A. Buttry and Se-Hee Lee
|
|
| Silicon is a promising anode material for
lithium ion batteries, but suffers from structural
degradation during operations. Here, the authors
combine silicon with a room temperature ionic
liquid to stabilize the electrode-electrolyte
interface and achieve long-term
cyclability. |
|
| 25 February 2015 | doi:
10.1038/ncomms7230 |
|
| Chemical
Sciences Materials
science Nanotechnology
|
| 分支杆菌由CRISPR干涉造成的基因沉默 |
|
| Eira Choudhary, Preeti Thakur,
Madhu Pareek and Nisheeth Agarwal
|
|
| Recombination-based tools for generating
targeted mutations in Mycobacterium tuberculosis
lack efficiency. Here the authors present a CRISPR
interference approach that is able to efficiently
repress the expression of target genes in
mycobacteria, in a rapid and cost-effective
manner. |
|
| 25 February 2015 | doi:
10.1038/ncomms7267 |
|
| Biological
Sciences Biotechnology
Genetics Microbiology
|
| 用于优化从个人基因组进行变异体发现的一个分析框架 OPEN |
|
| Gareth Highnam, Jason J. Wang,
Dean Kusler, Justin Zook, Vinaya Vijayan, Nir
Leibovich and David Mittelman |
|
| The standardization of clinical
sequencing data generation and analysis is of
critical importance. Here, the authors develop the
Genome Comparison and Analytic Testing platform to
facilitate the development of performance metrics
and comparisons of analysis tools for clinical
sequencing studies. |
|
| 25 February 2015 | doi:
10.1038/ncomms7275 |
|
| Biological
Sciences Bioinformatics
Genetics
|
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| |
LATEST CORRIGENDUM |
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| |
| Corrigendum: Duplication of a
promiscuous transcription factor drives the emergence of
a new regulatory network |
|
| Ksenia Pougach, Arnout Voet, Fyodor
A. Kondrashov, Karin Voordeckers, Joaquin F.
Christiaens, Bianka Baying, Vladimir Benes, Ryo Sakai,
Jan Aerts, Bo Zhu, Patrick Van Dijck and Kevin J.
Verstrepen |
|
| 26 February 2015 | doi:
10.1038/ncomms7543 |
|
| Biological Sciences
Evolution Genetics
|
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| |
| |
Latest Errata |
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|
| |
| Erratum: YAP inhibits squamous
transdifferentiation of Lkb1-deficient lung
adenocarcinoma through ZEB2-dependent DNp63
repression |
|
| Yijun Gao, Wenjing Zhang, Xiangkun
Han, Fuming Li, Xujun Wang, Rui Wang, Zhaoyuan Fang,
Xinyuan Tong, Shun Yao, Fei Li, Yan Feng, Yihua Sun,
Yingyong Hou, Zhongzhou Yang, Kunliang Guan, Haiquan
Chen, Lei Zhang and Hongbin Ji |
|
| 27 February 2015 | doi:
10.1038/ncomms7459 |
|
| Biological Sciences
Cancer Medical research
|
|
|
| |
| Erratum: miR-24 limits aortic
vascular inflammation and murine abdominal aneurysm
development |
|
| Lars Maegdefessel, Joshua M. Spin,
Uwe Raaz, Suzanne M. Eken, Ryuji Toh, Junya Azuma, Matti
Adam, Futoshi Nakagami, Helen M. Heymann, Ekaterina
Chernogubova, Hong Jin, Joy Roy, Rebecka Hultgren,
Kenneth Caidahl, Sonja Schrepfer, Anders Hamsten, Per
Eriksson, Michael V. McConnell, Ronald L. Dalman and
Philip S. Tsao et al.
|
|
| 26 February 2015 | doi:
10.1038/ncomms7506 |
|
| Biological Sciences
Medical research
|
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| Erratum: Synthetic retinal analogs
modify the spectral and kinetic characteristics of
microbial rhodopsin optogenetic tools |
|
| N AzimiHashemi, K Erbguth, A Vogt, T
Riemensperger, E Rauch, D Woodmansee, J Nagpal, M
Brauner, M Sheves, A Fiala, L Kattner, D Trauner, P
Hegemann, A Gottschalk and J F. Liewald
|
|
| 25 February 2015 | doi:
10.1038/ncomms7458 |
|
| Biological Sciences
Biochemistry Neuroscience
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