《自然》 目錄

Volume 553 Number 7687

Editorials

News

News Features

How to see a memory p.146

Every memory leaves its own imprint in the brain, and researchers are starting to work out what one looks like.

doi: 10.1038/d41586-018-00107-4

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News & Views

Cometary spin-down p.158

The rotation rate of a comet more than halved in two months — a much greater change than has previously been observed. This suggests that the comet is in a distinct evolutionary state and might soon reorient itself.

doi: 10.1038/d41586-018-00008-6

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Neuronal plasticity in nematode worms p.159

Neuronal activity induces changes in the connectivity of a neuron called DVB in adult male nematode worms. This discovery provides an opportunity to study a fundamental process in this powerful model organism.

doi: 10.1038/d41586-017-09031-5

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Dogma-breaking catalysis p.160

The catalysts conventionally used for industrially important hydrogenation reactions are expensive and generate toxic residues. Catalysts have now been reported that might lead to cheaper, less toxic alternatives.

doi: 10.1038/d41586-017-09006-6

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An ode to gene edits that prevent deafness p.162

Gene editing can prevent inherited deafness in mice by disabling a mutant version of a gene that causes hearing loss. Is this a turning point on the path towards treating some types of human deafness?

doi: 10.1038/d41586-017-08645-z

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Rule-breaking perovskites p.163

A material from the perovskite family of semiconductors emits light much more efficiently than expected. The explanation for this anomalous behaviour could lead to improvements in light-emitting technology.

doi: 10.1038/d41586-018-00012-w

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Articles

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells p.171

Endogenous and alcohol-derived acetaldehyde causes a specific pattern of DNA damage in haemopoietic stem cells; the effects are mitigated by detoxification, specific DNA repair mechanisms and a p53 response.

Juan I. Garaycoechea, Gerry P. Crossan, Frédéric Langevin, Lee Mulderrig, Sandra Louzada, Fentang Yang, Guillaume Guilbaud, Naomi Park, Sophie Roerink, Serena Nik-Zainal + et al.

doi: 10.1038/nature25154

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Letters

Rotation in [C ii]-emitting gas in two galaxies at a redshift of 6.8 p.178

The emission of singly ionized carbon is used to identify two galaxies with redshifts of nearly 7—corresponding to the Universe’s first billion years—and with velocity structures suggestive of rotation.

Renske Smit, Rychard J. Bouwens, Stefano Carniani, Pascal A. Oesch, Ivo Labbé, Garth D. Illingworth, Paul van der Werf, Larry D. Bradley, Valentino Gonzalez, Jacqueline A. Hodge + et al.

doi: 10.1038/nature24631

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An extreme magneto-ionic environment associated with the fast radio burst source FRB 121102 p.182

Polarimetric observations of the repeating fast radio burst source FRB 121102 suggest that the bursts may originate from a neutron star in the extreme magneto-ionic environment of an accreting massive black hole or supernova remnant.

D. Michilli, A. Seymour, J. W. T. Hessels, L. G. Spitler, V. Gajjar, A. M. Archibald, G. C. Bower, S. Chatterjee, J. M. Cordes, K. Gourdji + et al.

doi: 10.1038/nature25149

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Bright triplet excitons in caesium lead halide perovskites p.189

The lowest-energy exciton state in caesium lead halide perovskite nanocrystals is shown to be a bright triplet state, contrary to expectations that lowest-energy excitons should always be dark.

Michael A. Becker, Roman Vaxenburg, Georgian Nedelcu, Peter C. Sercel, Andrew Shabaev, Michael J. Mehl, John G. Michopoulos, Samuel G. Lambrakos, Noam Bernstein, John L. Lyons + et al.

doi: 10.1038/nature25147

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Fire frequency drives decadal changes in soil carbon and nitrogen and ecosystem productivity p.194

A meta-analysis and field data show that frequent fires in savannas and broadleaf forests decrease soil carbon and nitrogen over many decades; modelling shows that nitrogen loss drives carbon loss by reducing net primary productivity.

Adam F. A. Pellegrini, Anders Ahlström, Sarah E. Hobbie, Peter B. Reich, Lars P. Nieradzik, A. Carla Staver, Bryant C. Scharenbroch, Ari Jumpponen, William R. L. Anderegg, James T. Randerson + et al.

doi: 10.1038/nature24668

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Terminal Pleistocene Alaskan genome reveals first founding population of Native Americans p.203

An Ancient Beringian population from Late Pleistocene Alaska and the ancestors of other Native American groups descended from a single founding population that diversified around twenty thousand years ago.

J. Víctor Moreno-Mayar, Ben A. Potter, Lasse Vinner, Matthias Steinrücken, Simon Rasmussen, Jonathan Terhorst, John A. Kamm, Anders Albrechtsen, Anna-Sapfo Malaspinas, Martin Sikora + et al.

doi: 10.1038/nature25173

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Precision editing of the gut microbiota ameliorates colitis p.208

Tungstate inhibits molybdenum-cofactor-dependent microbial respiratory pathways and shows potential as a selective treatment for microbial imbalances that occur during inflammation of the gastrointestinal tract.

Wenhan Zhu, Maria G. Winter, Mariana X. Byndloss, Luisella Spiga, Breck A. Duerkop, Elizabeth R. Hughes, Lisa Büttner, Everton de Lima Romão, Cassie L. Behrendt, Christopher A. Lopez + et al.

doi: 10.1038/nature25172

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Clonal analysis of lineage fate in native haematopoiesis p.212

Transposon tagging to clonally trace progenitors and stem cells provides evidence for a substantially revised roadmap for unperturbed haematopoiesis, and highlights unique properties of multipotent progenitors and haematopoietic stem cells in situ.

Alejo E. Rodriguez-Fraticelli, Samuel L. Wolock, Caleb S. Weinreb, Riccardo Panero, Sachin H. Patel, Maja Jankovic, Jianlong Sun, Raffaele A. Calogero, Allon M. Klein & Fernando D. Camargo

doi: 10.1038/nature25168

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Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents p.217

CRISPR–Cas9 genome editing is used to correct a dominant-negative mutation in a mouse model of inherited deafness, resulting in improvements in cochlear function and hearing.

Xue Gao, Yong Tao, Veronica Lamas, Mingqian Huang, Wei-Hsi Yeh, Bifeng Pan, Yu-Juan Hu, Johnny H. Hu, David B. Thompson, Yilai Shu + et al.

doi: 10.1038/nature25164

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Opening of the human epithelial calcium channel TRPV6 p.233

The cryo-electron microscopy structure of the calcium channel TRPV6 in its open and closed states demonstrates a novel gating mechanism involving an alanine hinge.

Luke L. McGoldrick, Appu K. Singh, Kei Saotome, Maria V. Yelshanskaya, Edward C. Twomey, Robert A. Grassucci & Alexander I. Sobolevsky

doi: 10.1038/nature25182

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