《自然》 目录



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Wireless power on the move p.354

Most state-of-the-art methods of wireless energy delivery are inherently limited to static devices. An approach based on fundamental physics could overcome this limitation, opening up a wealth of applications. See Letter p.387

Geoffroy Lerosey

doi: 10.1038/546354a


Molecular mapping of Zika spread p.355

Evolutionary trees constructed using both newly sequenced and previously available Zika virus genomes reveal how the recent outbreak arose in Brazil and spread across the Americas. See Letters p.401, p.406 & p.411

Michael Worobey

doi: 10.1038/nature22495


Division enzyme regulates metabolism p.357

Cell division requires the action of key regulator proteins called cyclins and CDKs. It emerges that a cyclin–CDK complex can regulate cell metabolism, and targeting this metabolic regulation causes tumour regression in mice. See Letter p.426

Abigail S. Krall & Heather R. Christofk

doi: 10.1038/nature22504


How to suck like an octopus p.358

Rubber sheets that reversibly bind and release substrates have been made by copying a subtlety in the shape of octopus suckers. The findings reveal how macro-scale biological structures can influence function. See Letter p.396

Jonathan J. Wilker

doi: 10.1038/546358a


A decade of shared genomic associations p.360

A paper that analysed genetic variants in 14,000 people to identify disease-associated regions set the standard for collaborative genome-wide association studies and provided methodological advances whose effects are still felt today.

Teri A. Manolio

doi: 10.1038/546360a


Local metabolites linked to memory p.361

Production of the metabolite acetyl-CoA near specific regions of DNA modulates gene expression in mouse neurons during cellular differentiation and memory formation. See Article p.381

L. Ashley Watson & Li-Huei Tsai

doi: 10.1038/nature22498



Damming the rivers of the Amazon basin p.363

Edgardo M. Latrubesse, Eugenio Y. Arima, Thomas Dunne, Edward Park, Victor R. Baker, Fernando M. d’Horta, Charles Wight, Florian Wittmann, Jansen Zuanon, Paul A. Baker + et al.

doi: 10.1038/nature22333



Common genetic variation drives molecular heterogeneity in human iPSCs p.370

Genetic and phenotypic analysis reveals expression quantitative trait loci in human induced pluripotent stem cell lines associated with cancer and disease.

Helena Kilpinen, Angela Goncalves, Andreas Leha, Vackar Afzal, Kaur Alasoo, Sofie Ashford, Sendu Bala, Dalila Bensaddek, Francesco Paolo Casale, Oliver J. Culley + et al.

doi: 10.1038/nature22403

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A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis p.376

The establishment of a drug-discovery screening pipeline for cryptosporidiosis, and identification of pyrazolopyridines as selective ATP-competitive inhibitors of the Cryptosporidium lipid kinase PI(4)K.

Ujjini H. Manjunatha, Sumiti Vinayak, Jennifer A. Zambriski, Alexander T. Chao, Tracy Sy, Christian G. Noble, Ghislain M. C. Bonamy, Ravinder R. Kondreddi, Bin Zou, Peter Gedeck + et al.

doi: 10.1038/nature22337

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Slush-like polar structures in single-crystal relaxors p.391

Molecular dynamics simulations of the Pb(Mg1/3,Nb2/3)O3–PbTiO3 relaxor reveal a multi-domain state analogous to the slush state of water that provides an explanation for the unusual properties of relaxors.

Hiroyuki Takenaka, Ilya Grinberg, Shi Liu & Andrew M. Rappe

doi: 10.1038/nature22068

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Genomic epidemiology reveals multiple introductions of Zika virus into the United States p.401

Genome sequencing of Zika virus samples from infected patients and Aedes aegypti mosquitoes in Florida shows that the virus was probably introduced into the United States on multiple occasions, and that the Caribbean is the most likely source.

Nathan D. Grubaugh, Jason T. Ladner, Moritz U. G. Kraemer, Gytis Dudas, Amanda L. Tan, Karthik Gangavarapu, Michael R. Wiley, Stephen White, Julien Thézé, Diogo M. Magnani + et al.

doi: 10.1038/nature22400

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Establishment and cryptic transmission of Zika virus in Brazil and the Americas p.406

Virus genomes reveal the establishment of Zika virus in Brazil and the Americas, and provide an appropriate timeframe for baseline (pre-Zika) microcephaly in different regions.

N. R. Faria, J. Quick, I.M. Claro, J. Thézé, J. G. de Jesus, M. Giovanetti, M. U. G. Kraemer, S. C. Hill, A. Black, A. C. da Costa + et al.

doi: 10.1038/nature22401

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Zika virus evolution and spread in the Americas p.411

One hundred and ten Zika virus genomes from ten countries and territories involved in the Zika virus epidemic reveal rapid expansion of the epidemic within Brazil and multiple introductions to other regions.

Hayden C. Metsky, Christian B. Matranga, Shirlee Wohl, Stephen F. Schaffner, Catherine A. Freije, Sarah M. Winnicki, Kendra West, James Qu, Mary Lynn Baniecki, Adrianne Gladden-Young + et al.

doi: 10.1038/nature22402

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Principles of early human development and germ cell program from conserved model systems p.416

The authors trace the emergence of porcine primordial germ cells and develop in vitro models of primordial germ cell development from human and monkey pluripotent stem cells in order to provide insight into early human development.

Toshihiro Kobayashi, Haixin Zhang, Walfred W. C. Tang, Naoko Irie, Sarah Withey, Doris Klisch, Anastasiya Sybirna, Sabine Dietmann, David A. Contreras, Robert Webb + et al.

doi: 10.1038/nature22812

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Stability and function of regulatory T cells expressing the transcription factor T-bet p.421

Regulatory T cells expressing the transcription factor T-bet selectively suppress TH1 and CD8 T cells, but not TH2 or TH17 activation and associated autoimmunity.

Andrew G. Levine, Alejandra Medoza, Saskia Hemmers, Bruno Moltedo, Rachel E. Niec, Michail Schizas, Beatrice E. Hoyos, Ekaterina V. Putintseva, Ashutosh Chaudhry, Stanislav Dikiy + et al.

doi: 10.1038/nature22360

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The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival p.426

The cyclin D3–CDK6 kinase complex, which is overactive in some cancers, inhibits two key glycolysis enzymes and thereby enhances the levels of antioxidants in cells, promoting tumour cell survival.

Haizhen Wang, Brandon N. Nicolay, Joel M. Chick, Xueliang Gao, Yan Geng, Hong Ren, Hui Gao, Guizhi Yang, Juliet A. Williams, Jan M. Suski + et al.

doi: 10.1038/nature22797

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Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance p.431

Through drug exposure, a rare, transient transcriptional program characterized by high levels of expression of known resistance drivers can get ‘burned in’, leading to the selection of cells endowed with a transcriptional drug resistance and thus more chemoresistant cancers.

Sydney M. Shaffer, Margaret C. Dunagin, Stefan R. Torborg, Eduardo A. Torre, Benjamin Emert, Clemens Krepler, Marilda Beqiri, Katrin Sproesser, Patricia A. Brafford, Min Xiao + et al.

doi: 10.1038/nature22794

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