: Methods Articles
Research Highlights: We the curatorsTwo groups describe wiki platforms for community-based curation of gene annotations or biological pathways. Nature Methods, vol. 5 #9, pp754-755 |
Research Highlights: New sensors from oldA serendipitous discovery reveals that an existing fluorescent protein is actually a specific sensor for superoxide. Nature Methods, vol. 5 #9, pp756-756 |
Research Highlights: Recombination: it takes fourResearchers use tetrad analysis and high-density oligonucleotide tiling arrays to generate a high-resolution map of meiotic recombination events in budding yeast. Nature Methods, vol. 5 #9, pp754-755 |
News and Views: Genetically encoded Ca2+ sensors come of ageA decade after the introduction of genetically encoded Ca2+ indicator proteins (GECIs), a new generation of improved GECIs demonstrates their usefulness for the functional analysis of the mammalian brain in vivo. Nature Methods, vol. 5 #9, pp761-762 |
News and Views: Sex to the rescueApplying a classical solution to a cutting-edge problem, two groups used bacterial conjugation to construct Escherichia coli double mutants on a genome-wide scale. This will allow comprehensive genetic interaction screens in bacteria for the first time. Nature Methods, vol. 5 #9, pp759-760 |
Research Highlights: microRNAs—subtler than you thinkTwo research groups apply quantitative proteomics to study the effects of micro-RNAs on cellular proteins. Nature Methods, vol. 5 #9, pp753-753 |
Editorial: Method of the Year 2008: cast your vote!You can now nominate candidates and vote online to help select the Method of the Year 2008. Nature Methods, vol. 5 #9, pp749-749 |
Editorial: Target practiceA constant influx of new methods keeps research on microRNA biology fast-paced and can provide divergent vantage points. Nature Methods, vol. 5 #9, pp749-750 |
Brief Communication: Efficient microRNA capture and bar-coding via enzymatic oligonucleotide adenylationA simplified strategy to enzymatically preadenylate bar-coded oligonucleotides to be used for capturing microRNAs in biological samples is described. This efficient method should greatly facilitate multiplex analysis and profiling of microRNAs. Nature Methods, vol. 5 #9, pp777-779 |