: Molecular Cell Biology Articles
Review: Active DNA demethylation: many roads lead to RomeDNA methylation is one of the best-characterized epigenetic modifications and has been implicated in numerous biological processes, including transposable element silencing, genomic imprinting and X chromosome inactivation. Compared with other epigenetic modifications, DNA methylation is thought to be relatively stable. Despite its role in long-term Nature Reviews Molecular Cell Biology, vol. 11 #9, pp607-620 |
Review: Mitochondria and cell death: outer membrane permeabilization and beyondMitochondrial outer membrane permeabilization (MOMP) is often required for activation of the caspase proteases that cause apoptotic cell death. Various intermembrane space (IMS) proteins, such as cytochrome c, promote caspase activation following their mitochondrial release. As a consequence, mitochondrial outer membrane integrity is highly Nature Reviews Molecular Cell Biology, vol. 11 #9, pp621-632 |
Review: Cell adhesion: integrating cytoskeletal dynamics and cellular tensionCell migration affects all morphogenetic processes and contributes to numerous diseases, including cancer and cardiovascular disease. For most cells in most environments, movement begins with protrusion of the cell membrane followed by the formation of new adhesions at the cell front that link the actin Nature Reviews Molecular Cell Biology, vol. 11 #9, pp633-643 |
Review: Molecular mechanisms of organelle inheritance: lessons from peroxisomes in yeastPreserving a functional set of cytoplasmic organelles in a eukaryotic cell requires a process of accurate organelle inheritance at cell division. Studies of peroxisome inheritance in yeast have revealed that polarized transport of a subset of peroxisomes to the emergent daughter cell is balanced by Nature Reviews Molecular Cell Biology, vol. 11 #9, pp644-654 |
Review: Mitochondrial protein import: from proteomics to functional mechanismsMitochondria contain ?1,000 different proteins, most of which are imported from the cytosol. Two import pathways that direct proteins into the mitochondrial inner membrane and matrix have been known for many years. The identification of numerous new transport components in recent proteomic studies has led Nature Reviews Molecular Cell Biology, vol. 11 #9, pp655-667 |
Perspectives: New functions of aminoacyl-tRNA synthetases beyond translationOver the course of evolution, eukaryotic aminoacyl-tRNA synthetases (aaRSs) progressively incorporated domains and motifs that have no essential connection to aminoacylation reactions. Their accretive addition to virtually all aaRSs correlates with the progressive evolution and complexity of eukaryotes. Based on recent experimental findings focused on Nature Reviews Molecular Cell Biology, vol. 11 #9, pp668-674 |
