: Cancer Articles
Progress: Structural comparisons of class I phosphoinositide 3-kinasesClass I phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate cell growth. One of these kinases, PI3Kα, is frequently mutated in diverse tumour types. The recently determined structure of PI3Kα reveals features that distinguish this enzyme from related lipid kinases. In addition, wild-type PI3Kγ differs Nature Reviews Cancer, vol. 8 #9, pp665-669 |
Review: Cellular mechanisms of tumour suppression by the retinoblastoma geneThe retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad range of paediatric and adult cancers, and a plethora of cellular functions and partners have been identified for the RB protein. Data from human tumours and studies from mouse models indicate Nature Reviews Cancer, vol. 8 #9, pp671-682 |
Review: Diet and cancer prevention: the roles of observation and experimentationObservational epidemiology and experimentation by randomized controlled trials (RCTs) have been used to evaluate dietary factors in cancer prevention; however, consistency in findings has been elusive. In several circles, RCTs are viewed as more credible than observational studies. As the testing of dietary epidemiological findings Nature Reviews Cancer, vol. 8 #9, pp694-703 |
Perspective: Tailoring to RB: tumour suppressor status and therapeutic responseThe retinoblastoma tumour suppressor (RB) is a crucial regulator of cell-cycle progression that is invoked in response to a myriad of anti-mitogenic signals. It has been hypothesized that perturbations of the RB pathway confer a synonymous proliferative advantage to tumour cells; however, recent findings demonstrate Nature Reviews Cancer, vol. 8 #9, pp714-724 |
Review: A new MAFia in cancerLike JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their established role in human cancer — overexpression of the large Maf genes promotes the development of multiple myeloma — they can display tumour suppressor-like activity in specific cellular contexts, which Nature Reviews Cancer, vol. 8 #9, pp683-693 |
Perspective: Hypoxia, HIF1 and glucose metabolism in the solid tumourIt has been known for many years that cellular metabolism within the solid tumour is markedly different from that of the corresponding normal tissue. The transcription factor hypoxia-inducible factor 1 (HIF1) has been implicated in regulating many of the genes that are responsible for the Nature Reviews Cancer, vol. 8 #9, pp705-713 |
Perspective: Optical imaging for cervical cancer detection: solutions for a continuing global problemCervical cancer is the leading cause of cancer death for women in developing countries. Optical technologies can improve the accuracy and availability of cervical cancer screening. For example, battery-powered digital cameras can obtain multi-spectral images of the entire cervix, highlighting suspicious areas, and high-resolution optical Nature Reviews Cancer, vol. 8 #9, pp725-731 |