There’s no room for COVID complacency in 2023 p.7

doi: 10.1038/d41586-022-04476-9

The science events to watch for in 2023 p.11

doi: 10.1038/d41586-022-04444-3

After AlphaFold: protein-folding contest seeks next big breakthrough p.13

doi: 10.1038/d41586-022-04438-1

Are we in the Anthropocene? Geologists could define new epoch for Earth p.14

doi: 10.1038/d41586-022-04428-3

The ‘breakthrough’ obesity drugs that have stunned researchers p.16

doi: 10.1038/d41586-022-04505-7

Twitter changed science — what happens now it’s in turmoil? p.19

doi: 10.1038/d41586-022-04506-6

Heartbeat of brain tumours targeted p.29

Analysis of an invasive brain cancer reveals that networks of tumour cells are linked to small groups of ‘pacemaker’ cells in which levels of calcium ions pulse periodically, driving a signal through the network that causes tumour growth.

doi: 10.1038/d41586-022-04354-4

Senescent cells damage the body throughout life p.30

Cells in a state of arrested growth, called senescence, have been characterized in skeletal muscle in mice. Senescent cells promote inflammation and block regeneration, and thus might induce harmful changes in aged muscle.

doi: 10.1038/d41586-022-04430-9

Global estimates of excess deaths from COVID-19 p.31

Estimating the number of deaths attributable to COVID-19 around the world is a complex task — as highlighted by one attempt to measure global excess mortality in 2020 and 2021.

doi: 10.1038/d41586-022-04138-w

Electric switch found for a superconductor p.33

Ferroelectricity has been found in a superconducting compound. Strong coupling between these two properties enables ferroelectric control of the superconductivity, which could prove useful for quantum devices.

doi: 10.1038/d41586-022-04491-w

How to feed the world while reducing nitrogen pollution p.34

An analysis of more than 1,500 field observations has identified a collection of agricultural practices that can improve the use of nitrogen fertilizers — boosting crop yields while reducing environmental pollution.

doi: 10.1038/d41586-022-04490-x

The WHO estimates of excess mortality associated with the COVID-19 pandemic p.130

doi: 10.1038/s41586-022-05522-2

Intracluster light is already abundant at redshift beyond unity p.37

doi: 10.1038/s41586-022-05396-4

Photonic flatband resonances for free-electron radiation p.42

doi: 10.1038/s41586-022-05387-5

Coupled ferroelectricity and superconductivity in bilayer T_d-MoTe₂ p.48

doi: 10.1038/s41586-022-05521-3

Ultrathin quantum light source with van der Waals NbOCl₂ crystal p.53

doi: 10.1038/s41586-022-05393-7

Hydroxamic acid pre-adsorption raises the efficiency of cosensitized solar cells p.60

doi: 10.1038/s41586-022-05460-z

Solar-to-hydrogen efficiency of more than 9% in photocatalytic water splitting p.66

doi: 10.1038/s41586-022-05399-1

A few-layer covalent network of fullerenes p.71

doi: 10.1038/s41586-022-05401-w

Cost-effective mitigation of nitrogen pollution from global croplands p.77

doi: 10.1038/s41586-022-05481-8

Extreme redox variations in a superdeep diamond from a subducted slab p.85

doi: 10.1038/s41586-022-05392-8

Neogene burial of organic carbon in the global ocean p.90

doi: 10.1038/s41586-022-05413-6

Recurrent repeat expansions in human cancer genomes p.96

doi: 10.1038/s41586-022-05515-1

Cortical–hippocampal coupling during manifold exploration in motor cortex p.103

doi: 10.1038/s41586-022-05533-z

A cortico-collicular circuit for orienting to shelter during escape p.111

doi: 10.1038/s41586-022-05553-9

Microglia regulate central nervous system myelin growth and integrity p.120

doi: 10.1038/s41586-022-05534-y

Papers and patents are becoming less disruptive over time p.138

doi: 10.1038/s41586-022-05543-x

NLR surveillance of pathogen interference with hormone receptors induces immunity p.145

doi: 10.1038/s41586-022-05529-9

Periodic inhibition of Erk activity drives sequential somite segmentation p.153

doi: 10.1038/s41586-022-05527-x

CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization p.160

doi: 10.1038/s41586-022-05507-1

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration p.169

doi: 10.1038/s41586-022-05535-x

Autonomous rhythmic activity in glioma networks drives brain tumour growth p.179

doi: 10.1038/s41586-022-05520-4

R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response p.187

doi: 10.1038/s41586-022-05545-9

BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network p.195

doi: 10.1038/s41586-022-05551-x