How Nature contributed to science’s discriminatory legacy p.875

We want to acknowledge — and learn from — our history.

doi: 10.1038/d41586-022-03035-6

These scientists traced a new coronavirus lineage to one office — through sewage p.883

Researchers are hunting through waste water for heavily mutated SARS-CoV-2 variants that could be the next Omicron.

doi: 10.1038/d41586-022-02996-y

NASA’s Mars rover makes ‘fantastic’ find in search for past life p.885

Perseverance has collected four rock samples from an ancient river delta where organisms might have thrived.

doi: 10.1038/d41586-022-02968-2

Most US professors are trained at same few elite universities p.887

‘Jarring’ study reveals hiring bias at US institutions.

doi: 10.1038/d41586-022-02998-w

China’s extreme weather challenges scientists trying to study it p.888

A severe heatwave in parts of China exacerbated a drought and fuelled wildfires.

doi: 10.1038/d41586-022-02954-8

AlphaFold developers win US$3-million Breakthrough Prize p.889

DeepMind’s system for predicting the 3D structure of proteins is among five recipients of science’s most lucrative awards.

doi: 10.1038/d41586-022-02999-9

Bolsonaro’s troubled legacy for science, health and the environment p.890

doi: 10.1038/d41586-022-03038-3

Fossils reveal the deep roots of jawed vertebrates p.897

Scarce evidence indicates that key evolutionary steps for jawed vertebrates occurred during or before the Silurian period, 444 million to 419 million years ago. Fossil finds pull back the curtain on this interval.

doi: 10.1038/d41586-022-02973-5

Hybrid laser-trapping technique lights the way for neutral atoms p.898

An experimental platform that uses two different tools for controlling neutral atoms with laser light combines speed with scalability. The approach provides a crucial step towards realizing innovative quantum algorithms and simulations.

doi: 10.1038/d41586-022-02953-9

Life brought to artificial cells p.900

Can artificial cells be built from basic components? Systems that have complex architectures and functions evocative of natural cells have been prepared by recycling the contents of bacterial cells in synthetic droplets.

doi: 10.1038/d41586-022-02231-8

The origins of medulloblastoma tumours in humans p.901

How certain subgroups of a childhood brain tumour called a medulloblastoma arise has been unclear. Evidence now implicates a cell type found only in developing human brains as the originator of these tumours.

doi: 10.1038/d41586-022-02951-x

Outer regions of galaxy clusters host radio megahaloes p.903

Observations reveal the presence of large volumes of ionized gas surrounding four galaxy clusters. The properties of these ‘megahaloes’ are distinct from those of similar haloes near the clusters, implying different formation mechanisms.

doi: 10.1038/d41586-022-02972-6

Lifting the veil on the oldest-known animals p.904

Gaps in the fossil record mean that the origins of ancient animals such as jellyfish and corals have remained a mystery. Now, a long-awaited fossil discovery reveals key features of this group during the early stages of its evolution.

doi: 10.1038/d41586-022-02893-4

A nomenclature consensus for nervous system organoids and assembloids p.907

doi: 10.1038/s41586-022-05219-6

Galaxy clusters enveloped by vast volumes of relativistic electrons p.911

doi: 10.1038/s41586-022-05149-3

Observations of a Magellanic Corona p.915

doi: 10.1038/s41586-022-05090-5

Universal control of a six-qubit quantum processor in silicon p.919

doi: 10.1038/s41586-022-05117-x

Topological Chern vectors in three-dimensional photonic crystals p.925

doi: 10.1038/s41586-022-05077-2

Photonic topological insulator induced by a dislocation in three dimensions p.931

doi: 10.1038/s41586-022-05129-7

Anomalous slip in body-centred cubic metals p.936

doi: 10.1038/s41586-022-05087-0

Tracking single adatoms in liquid in a transmission electron microscope p.942

doi: 10.1038/s41586-022-05130-0

Antarctic calving loss rivals ice-shelf thinning p.948

doi: 10.1038/s41586-022-05037-w

The oldest complete jawed vertebrates from the early Silurian of China p.954

doi: 10.1038/s41586-022-05136-8

Galeaspid anatomy and the origin of vertebrate paired appendages p.959

doi: 10.1038/s41586-022-04897-6

The oldest gnathostome teeth p.964

doi: 10.1038/s41586-022-05166-2

Spiny chondrichthyan from the lower Silurian of South China p.969

doi: 10.1038/s41586-022-05233-8

Control of cell state transitions p.975

doi: 10.1038/s41586-022-05194-y

Glucose-driven TOR–FIE–PRC2 signalling controls plant development p.986

doi: 10.1038/s41586-022-05171-5

Pandemic-scale phylogenomics reveals the SARS-CoV-2 recombination landscape p.994

doi: 10.1038/s41586-022-05189-9

Long-primed germinal centres with enduring affinity maturation and clonal migration p.998

doi: 10.1038/s41586-022-05216-9

CLN3 is required for the clearance of glycerophosphodiesters from lysosomes p.1005

doi: 10.1038/s41586-022-05221-y

Unified rhombic lip origins of group 3 and group 4 medulloblastoma p.1012

doi: 10.1038/s41586-022-05208-9

Failure of human rhombic lip differentiation underlies medulloblastoma formation p.1021

doi: 10.1038/s41586-022-05215-w

Living material assembly of bacteriogenic protocells p.1029

doi: 10.1038/s41586-022-05223-w

A mechanism for oxidative damage repair at gene regulatory elements p.1038

doi: 10.1038/s41586-022-05217-8

Columnar structure of human telomeric chromatin p.1048

doi: 10.1038/s41586-022-05236-5

Methotrexate recognition by the human reduced folate carrier SLC19A1 p.1056

doi: 10.1038/s41586-022-05168-0