The case for lotteries as a tiebreaker of quality in research funding p.653

More funders should consider using randomization to choose grant recipients when decisions are too close to call.

doi: 10.1038/d41586-022-02959-3

How fast fashion can cut its staggering environmental impact p.653

The textiles industry urgently needs input from researchers to help it to embrace the circular economy.

doi: 10.1038/d41586-022-02914-2

Scientists are using AI to dream up revolutionary new proteins p.661

Huge advances in artificial intelligence mean researchers can design completely original molecules in seconds instead of months.

doi: 10.1038/d41586-022-02947-7

How deadly is monkeypox? What scientists know p.663

Symptoms of severe disease differ from those seen during past outbreaks, causing researchers to re-evaluate their assumptions.

doi: 10.1038/d41586-022-02931-1

Why NASA’s Artemis Moon launch is delayed — and what’s next p.664

doi: 10.1038/d41586-022-02867-6

Did this gene give modern human brains their edge? p.665

A mutation present in modern humans seems to drive greater neuron growth than does an ancient hominin version.

doi: 10.1038/d41586-022-02895-2

Millions are mourning the Queen — what’s the science behind public grief? p.666

Most of the people mourning the death of Queen Elizabeth II were not close to her — research can shed light on the nature of their grief.

doi: 10.1038/d41586-022-02945-9

Pakistan’s floods have displaced 32 million people — here’s how researchers are helping p.667

doi: 10.1038/d41586-022-02879-2

The controversial embryo tests that promise a better baby p.668

doi: 10.1038/d41586-022-02961-9

Atmospheric waves reinforced tsunami after Tongan eruption p.677

The global tsunami and atmospheric waves that followed the eruption of the Tongan volcano Hunga Tonga–Hunga Ha’apai were observed around the world. Analysing the data could reshape our understanding of such events.

doi: 10.1038/d41586-022-01855-0

Neuronal culprits of sickness behaviours p.679

Specialized neurons that are activated after infection have been identified in the brain. These neurons orchestrate an array of sickness behaviours that help the body to cope with disease and to fight infection.

doi: 10.1038/d41586-022-02321-7

Interfaces boost response to electric fields in layered oxides p.680

A structure with precisely engineered layers produces a giant strain in an electric field. The interplay between structural distortions and electric dipoles at the interfaces between layers could aid material and device design.

doi: 10.1038/d41586-022-02948-6

Two-drug trick to target the brain blocks toxicity in the body p.681

When combined, two drugs alter the activity of a protein complex called target of rapamycin complex 1 such that it is inhibited in the brain but not the body, enabling the treatment of brain tumours in mice without systemic toxicity.

doi: 10.1038/d41586-022-02892-5

Stressful start causes chromosome errors in human embryos p.683

Analysis of early human embryos reveals that DNA duplication after fertilization is highly inefficient. This causes DNA damage, chromosome breaks and abnormal numbers of chromosomes, impairing embryo development.

doi: 10.1038/d41586-022-02949-5

A fast radio burst source at a complex magnetized site in a barred galaxy p.685

doi: 10.1038/s41586-022-05071-8

An elementary quantum network of entangled optical atomic clocks p.689

doi: 10.1038/s41586-022-05088-z

Atomically engineered interfaces yield extraordinary electrostriction p.695

doi: 10.1038/s41586-022-05073-6

A dynamically reprogrammable surface with self-evolving shape morphing p.701

doi: 10.1038/s41586-022-05061-w

Aerial additive manufacturing with multiple autonomous robots p.709

doi: 10.1038/s41586-022-04988-4

Large harvested energy with non-linear pyroelectric modules p.718

doi: 10.1038/s41586-022-05069-2

Electroreduction of nitrogen with almost 100% current-to-ammonia efficiency p.722

doi: 10.1038/s41586-022-05108-y

Diverse tsunamigenesis triggered by the Hunga Tonga-Hunga Ha’apai eruption p.728

doi: 10.1038/s41586-022-05170-6

Global Tonga tsunami explained by a fast-moving atmospheric source p.734

doi: 10.1038/s41586-022-04926-4

Surface-to-space atmospheric waves from Hunga Tonga–Hunga Ha’apai eruption p.741

doi: 10.1038/s41586-022-05012-5

Divergent genomic trajectories predate the origin of animals and fungi p.747

doi: 10.1038/s41586-022-05110-4

DOCK2 is involved in the host genetics and biology of severe COVID-19 p.754

doi: 10.1038/s41586-022-05163-5

Brainstem ADCYAP1⁺ neurons control several aspects of sickness behaviour p.761

doi: 10.1038/s41586-022-05161-7

Hippocampal astrocytes encode reward location p.772

doi: 10.1038/s41586-022-05146-6

Independent origins of fetal liver haematopoietic stem and progenitor cells p.779

doi: 10.1038/s41586-022-05203-0

Coronaviruses exploit a host cysteine-aspartic protease for replication p.785

doi: 10.1038/s41586-022-05148-4

The mechanism of RNA capping by SARS-CoV-2 p.793

doi: 10.1038/s41586-022-05185-z

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 p.801

doi: 10.1038/s41586-022-05128-8

A universal coupling mechanism of respiratory complex I p.808

doi: 10.1038/s41586-022-05199-7

A phosphoinositide signalling pathway mediates rapid lysosomal repair p.815

doi: 10.1038/s41586-022-05164-4

Brain-restricted mTOR inhibition with binary pharmacology p.822

doi: 10.1038/s41586-022-05213-y

CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1 p.829

doi: 10.1038/s41586-022-05204-z

Structures of a phycobilisome in light-harvesting and photoprotected states p.835

doi: 10.1038/s41586-022-05156-4

Autoantibody mimicry of hormone action at the thyrotropin receptor p.846

doi: 10.1038/s41586-022-05159-1

Hormone- and antibody-mediated activation of the thyrotropin receptor p.854

doi: 10.1038/s41586-022-05173-3