Preventive HIV drug shows urgent need for transparency on pricing p.239

The drug cabotegravir could be a game-changer in the fight against HIV/AIDS — but we need to know why it costs so much.

doi: 10.1038/d41586-022-02136-6

Pig organs partially revived in dead animals — researchers are stunned p.247

Scientists warn that the findings aren’t yet clinically relevant but say the research raises ethical questions about the definition of death.

doi: 10.1038/d41586-022-02112-0

Billions more for US science: how the landmark spending plan will boost research p.249

After two years of negotiations, the US Congress finally passed legislation to massively increase science and technology research and enhance competitiveness in the semiconductor industry.

doi: 10.1038/d41586-022-02086-z

Could machine learning fuel a reproducibility crisis in science? p.250

‘Data leakage’ threatens the reliability of machine-learning use across disciplines, researchers warn.

doi: 10.1038/d41586-022-02035-w

How humans’ ability to digest milk evolved from famine and disease p.251

Landmark study is the first major effort to quantify how lactose tolerance developed.

doi: 10.1038/d41586-022-02067-2

‘Everybody is so excited’: South Korea set for first Moon mission p.252

The Korea Pathfinder Lunar Orbiter, or Danuri, has captivated scientists and the public.

doi: 10.1038/d41586-022-02066-3

Pandemic drives largest drop in childhood vaccinations in 30 years p.253

Last year alone, 25 million children missed out on immunizations against infections such as measles and polio, leading to avoidable outbreaks of disease.

doi: 10.1038/d41586-022-02051-w

The effects of overturning Roe v. Wade in seven simple charts p.254

doi: 10.1038/d41586-022-02139-3

Long-COVID treatments: why the world is still waiting p.258

doi: 10.1038/d41586-022-02140-w

Sticky logic programs bacteria to form multicellular patterns p.267

The engineering of cells to express synthetic adhesion molecules creates a simple logic for patterning cell populations with visible boundaries. The approach paves the way for smart living materials and programmable biosensors.

doi: 10.1038/d41586-022-02102-2

The mystery of early milk consumption in Europe p.268

What underpins how humans evolved the capacity to consume milk during adulthood? A look at the connection between health and the genetic changes needed to break down milk offers a surprising new perspective.

doi: 10.1038/d41586-022-02041-y

Magnetically soft but mechanically tough alloys p.270

Soft magnetic materials can be magnetized and demagnetized by weak magnetic fields, but lack the strength, toughness and malleability needed for many applications. An alloy that solves this problem has now been developed.

doi: 10.1038/d41586-022-02103-1

A short burst of reward curbs the addictiveness of ketamine p.271

An analysis of ketamine and cocaine use in mice reveals that the drugs trigger release of the neurotransmitter dopamine through different mechanisms, and indicates that the risk of addiction to ketamine is low.

doi: 10.1038/d41586-022-01948-w

Improved organ recovery after oxygen deprivation p.273

A modified method for delivering oxygen to the whole body can restore function in pig organs one hour after the animals have died. The achievement points to ways to improve transplants and the treatment of strokes and heart attacks.

doi: 10.1038/d41586-022-01995-3

Response of the East Antarctic Ice Sheet to past and future climate change p.275

doi: 10.1038/s41586-022-04946-0

Experimental demonstration of optical stochastic cooling p.287

doi: 10.1038/s41586-022-04969-7

Realizing a 1D topological gauge theory in an optically dressed BEC p.293

doi: 10.1038/s41586-022-04943-3

Quantum cascade of correlated phases in trigonally warped bilayer graphene p.298

doi: 10.1038/s41586-022-04937-1

Self-emergence of robust solitons in a microcavity p.303

doi: 10.1038/s41586-022-04957-x

A mechanically strong and ductile soft magnet with extremely low coercivity p.310

doi: 10.1038/s41586-022-04935-3

Perovskite superlattices with efficient carrier dynamics p.317

doi: 10.1038/s41586-022-04961-1

4-bit adhesion logic enables universal multicellular interface patterning p.324

doi: 10.1038/s41586-022-04944-2

Giant impacts and the origin and evolution of continents p.330

doi: 10.1038/s41586-022-04956-y

Dairying, diseases and the evolution of lactase persistence in Europe p.336

doi: 10.1038/s41586-022-05010-7

The developing bird pelvis passes through ancestral dinosaurian conditions p.346

doi: 10.1038/s41586-022-04982-w

Transcriptome variation in human tissues revealed by long-read sequencing p.353

doi: 10.1038/s41586-022-05035-y

Spatially resolved clonal copy number alterations in benign and malignant tissue p.360

doi: 10.1038/s41586-022-05023-2

Dual action of ketamine confines addiction liability p.368

doi: 10.1038/s41586-022-04993-7

Dopamine subsystems that track internal states p.374

doi: 10.1038/s41586-022-04954-0

Cortical feedback loops bind distributed representations of working memory p.381

doi: 10.1038/s41586-022-05014-3

Teixobactin kills bacteria by a two-pronged attack on the cell envelope p.390

doi: 10.1038/s41586-022-05019-y

A physical wiring diagram for the human immune system p.397

doi: 10.1038/s41586-022-05028-x

Cellular recovery after prolonged warm ischaemia of the whole body p.405

doi: 10.1038/s41586-022-05016-1

Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion p.413

doi: 10.1038/s41586-022-05006-3

Brown-fat-mediated tumour suppression by cold-altered global metabolism p.421

doi: 10.1038/s41586-022-05030-3

Architecture and self-assembly of the jumbo bacteriophage nuclear shell p.429

doi: 10.1038/s41586-022-05013-4