Why a vaccine hub for low-income countries must succeed p.211

A new initiative aims to shift the dangerous imbalance in access to medicines, laid bare by the COVID-19 pandemic. It deserves support.

doi: 10.1038/d41586-022-01895-6

Memo to Boris Johnson’s successor: tell the truth, respect evidence and restore trust p.212

The UK government must stop picking fights with universities and reset the country’s relationship with the European Union.

doi: 10.1038/d41586-022-01894-7

Upgraded LHC begins epic run to search for new physics p.219

After a three-year shutdown, the Large Hadron Collider will smash particles together at the highest energies yet.

doi: 10.1038/d41586-022-01859-w

Happy birthday, Higgs boson! What we do and don’t know about the particle p.220

Physicists are celebrating ten years since the Higgs boson’s discovery. But many of its properties remain mysterious.

doi: 10.1038/d41586-022-01834-5

US Supreme Court hobbles the EPA’s authority over climate emissions p.222

Legal ruling limits the environmental agency’s regulatory powers, hamstringing Biden’s climate plan.

doi: 10.1038/d41586-022-01796-8

Clinical trials for pig-to-human organ transplants inch closer p.223

US regulatory agency signals willingness to allow first xenotransplant trials.

doi: 10.1038/d41586-022-01861-2

Ukrainian mathematician becomes second woman to win prestigious Fields Medal p.224

Maryna Viazovska, who works on the geometry of spheres, is one of four winners of the coveted prize this year.

doi: 10.1038/d41586-022-00470-3

What polio’s UK presence means for global health p.225

doi: 10.1038/d41586-022-01802-z

Unseating big pharma: the radical plan for vaccine equity p.226

doi: 10.1038/d41586-022-01898-3

Sediment study finds the pulse of tropical glaciers p.241

In regions of the globe at middle and high latitudes, glacial periods have waxed and waned for hundreds of millennia. Glacier-derived sediment in a Peruvian lake suggests that tropical glaciers have moved to a similar beat.

doi: 10.1038/d41586-022-01841-6

A gene-expression axis defines neuron behaviour p.243

A combination of functional imaging and gene-expression profiling in brain tissue has been used to unravel the properties of 35 subtypes of neuron in mice, revealing a gene-expression axis that governs each subtype’s activity.

doi: 10.1038/d41586-022-01640-z

100-year-old pandemic flu viruses yield new genomes p.244

Lung samples housed in medical archives have yielded three genomes for the influenza A virus that caused the 1918 global pandemic. The sequences reveal mutations that might have triggered the pandemic’s devastating second wave.

doi: 10.1038/d41586-022-01741-9

Odd living matter defies the golden rule of mechanics p.246

Self-assembling ‘crystals’ of starfish embryos exhibit a curious behaviour termed odd elasticity, which seemingly violates Newton’s laws of classical mechanics. This discovery poses questions for physicists and biologists alike.

doi: 10.1038/d41586-022-01840-7

Norovirus from the mouths of babes p.247

The discovery that gut viruses can be transmitted from mouse pups to their mothers in saliva during breastfeeding reveals previously unrecognized sites of viral replication and means of viral transmission.

doi: 10.1038/d41586-022-01731-x

Inflammatory memory and tissue adaptation in sickness and in health p.249

doi: 10.1038/s41586-022-04919-3

Sub-second periodicity in a fast radio burst p.256

doi: 10.1038/s41586-022-04841-8

Nuclear moments of indium isotopes reveal abrupt change at magic number 82 p.260

doi: 10.1038/s41586-022-04818-7

Optical observation of single spins in silicon p.266

doi: 10.1038/s41586-022-04821-y

Measuring the knot of non-Hermitian degeneracies and non-commuting braids p.271

doi: 10.1038/s41586-022-04796-w

Elastocaloric determination of the phase diagram of Sr₂RuO₄ p.276

doi: 10.1038/s41586-022-04820-z

Anti-reflection structure for perfect transmission through complex media p.281

doi: 10.1038/s41586-022-04843-6

Odd dynamics of living chiral crystals p.287

doi: 10.1038/s41586-022-04889-6

Local nanoscale phase impurities are degradation sites in halide perovskites p.294

doi: 10.1038/s41586-022-04872-1

700,000 years of tropical Andean glaciation p.301

doi: 10.1038/s41586-022-04873-0

Life rather than climate influences diversity at scales greater than 40 million years p.307

doi: 10.1038/s41586-022-04867-y

Grey wolf genomic history reveals a dual ancestry of dogs p.313

doi: 10.1038/s41586-022-04824-9

Targeting thalamic circuits rescues motor and mood deficits in PD mice p.321

doi: 10.1038/s41586-022-04806-x

A transcriptomic axis predicts state modulation of cortical interneurons p.330

doi: 10.1038/s41586-022-04915-7

Increasing the resilience of plant immunity to a warming climate p.339

doi: 10.1038/s41586-022-04902-y

Enteric viruses replicate in salivary glands and infect through saliva p.345

doi: 10.1038/s41586-022-04895-8

Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination p.351

doi: 10.1038/s41586-022-04865-0

Omicron infection enhances Delta antibody immunity in vaccinated persons p.356

doi: 10.1038/s41586-022-04830-x

Potentiating adoptive cell therapy using synthetic IL-9 receptors p.360

doi: 10.1038/s41586-022-04801-2

cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers p.366

doi: 10.1038/s41586-022-04847-2

A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel p.374

doi: 10.1038/s41586-022-04903-x

Core control principles of the eukaryotic cell cycle p.381

doi: 10.1038/s41586-022-04798-8

De novo design of discrete, stable 3₁₀-helix peptide assemblies p.387

doi: 10.1038/s41586-022-04868-x

Structure of the Dicer-2–R2D2 heterodimer bound to a small RNA duplex p.393

doi: 10.1038/s41586-022-04790-2

Structural insights into dsRNA processing by Drosophila Dicer-2–Loqs-PD p.399

doi: 10.1038/s41586-022-04911-x