Particle physics isn’t going to die — even if the LHC finds no new particles p.7

On the tenth anniversary of the discovery of the Higgs boson, it’s worth emphasizing that there’s a lot more to particle physics than particle hunting.

doi: 10.1038/d41586-022-01819-4

Europe must not backslide on climate action despite war in Ukraine p.8

European nations led the world in promoting strong climate action. They risk undoing all of that work now that European energy security is at risk.

doi: 10.1038/d41586-022-01820-x

Wade: US researchers warn of what’s to come" rel="external">After Roe v. Wade: US researchers warn of what’s to come p.15

Years of studies point to the negative economic and health effects of restricting access to abortions.

doi: 10.1038/d41586-022-01775-z

Monkeypox in Africa: the science the world ignored p.17

African researchers have been warning about monkeypox outbreaks for years. As vaccines are deployed globally, they worry they will be left behind.

doi: 10.1038/d41586-022-01686-z

Fast-evolving COVID variants complicate vaccine updates p.18

COVID-19 vaccines are due for an upgrade, scientists say, but emerging variants and fickle immune reactions mean it’s not clear what new jabs should look like.

doi: 10.1038/d41586-022-01771-3

Mysterious child hepatitis continues to vex researchers p.20

US cases of liver inflammation among children have remained flat, but UK cases seem to have risen, leading some to suggest a coronavirus contribution.

doi: 10.1038/d41586-022-01706-y

Rare ‘triple’ La Niña climate event looks likely — what does the future hold? p.21

Meteorologists are forecasting a third consecutive year of La Niña. Some researchers say similar conditions could become more common as the planet warms.

doi: 10.1038/d41586-022-01668-1

Did COVID vaccine mandates work? What the data say p.22

doi: 10.1038/d41586-022-01827-4

Cancer cells spread aggressively during sleep p.33

The deadly spread of cancer occurs predominantly during sleep, as revealed by an analysis of migrating human tumour cells in the bloodstream. What are the implications of this finding for the treatment of cancer?

doi: 10.1038/d41586-022-01639-6

Topology turns the crank on a magnetoelectric switch p.34

A mechanism resembling a crankshaft switches the electric polarization of a material in response to changes in an applied magnetic field. The resulting four-state switch is linked to the material’s intriguing topology.

doi: 10.1038/d41586-022-01786-w

Touch-evoked itch pinned on Piezo1 ion-channel protein p.36

The sensation of touch-evoked itch is common in people who have chronic itch conditions. Evidence in mice now suggests that the mechanoreceptor protein Piezo1 underlies this sensation.

doi: 10.1038/d41586-022-01571-9

Synthetic molecular cluster hints at mechanism of nitrogen fixation p.37

Enzymes use molecular clusters containing iron and sulfur atoms to bind and ‘fix’ nitrogen gas into a bioavailable form. A synthetic cluster that binds and reduces nitrogen molecules casts light on the mechanism of fixation.

doi: 10.1038/d41586-022-01787-9

A cell atlas for migraine research p.39

The trigeminal nerve has a key role in migraine. An atlas of cell types and gene-expression profiles for cells in this nerve in mice and humans promises to improve our understanding of head pain.

doi: 10.1038/d41586-022-01479-4

The Higgs boson turns ten p.41

doi: 10.1038/s41586-022-04899-4

Turbulent cold flows gave birth to the first quasars p.48

doi: 10.1038/s41586-022-04813-y

A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery p.52

doi: 10.1038/s41586-022-04893-w

A portrait of the Higgs boson by the CMS experiment ten years after the discovery p.60

doi: 10.1038/s41586-022-04892-x

Entangling single atoms over 33 km telecom fibre p.69

doi: 10.1038/s41586-022-04764-4

Direct observation of vortices in an electron fluid p.74

doi: 10.1038/s41586-022-04794-y

Topologically protected magnetoelectric switching in a multiferroic p.81

doi: 10.1038/s41586-022-04851-6

Nitrogen reduction by the Fe sites of synthetic [Mo₃S₄Fe] cubes p.86

doi: 10.1038/s41586-022-04848-1

Optimization of avian perching manoeuvres p.91

doi: 10.1038/s41586-022-04861-4

Whole-genome sequencing reveals host factors underlying critical COVID-19 p.97

doi: 10.1038/s41586-022-04576-6

PIEZO1 transduces mechanical itch in mice p.104

doi: 10.1038/s41586-022-04860-5

Biosynthetic potential of the global ocean microbiome p.111

doi: 10.1038/s41586-022-04862-3

Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2 p.119

doi: 10.1038/s41586-022-04856-1

Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost p.128

doi: 10.1038/s41586-022-04778-y

cBAF complex components and MYC cooperate early in CD8⁺ T cell fate p.135

doi: 10.1038/s41586-022-04849-0

Ablation of cDC2 development by triple mutations within the Zeb2 enhancer p.142

doi: 10.1038/s41586-022-04866-z

Deciphering the immunopeptidome in vivo reveals new tumour antigens p.149

doi: 10.1038/s41586-022-04839-2

The metastatic spread of breast cancer accelerates during sleep p.156

doi: 10.1038/s41586-022-04875-y

GREM1 is required to maintain cellular heterogeneity in pancreatic cancer p.163

doi: 10.1038/s41586-022-04888-7

OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage p.169

doi: 10.1038/s41586-022-04842-7

Compatibility rules of human enhancer and promoter sequences p.176

doi: 10.1038/s41586-022-04877-w

eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining p.185

doi: 10.1038/s41586-022-04858-z

Cryo-EM structure of a type IV secretion system p.191

doi: 10.1038/s41586-022-04859-y