The toll of menopause: how universities can help p.395

Some women are leaving science because employers are failing to support them during this stage of life. That can’t be right.

doi: 10.1038/d41586-022-01297-8

Nature journals raise the bar on sex and gender reporting in research p.396

Authors will be prompted to provide details on how sex and gender were considered in study design.

doi: 10.1038/d41586-022-01218-9

Black hole at the centre of our Galaxy imaged for the first time p.403

The Event Horizon Telescope network has captured the second-ever direct image of a black hole — called Sagittarius A* — at the centre of the Milky Way.

doi: 10.1038/d41586-022-01320-y

China expands control over genetic data used in scientific research p.405

Guidelines released this year are the latest regulations to protect China’s genetic resources, but some scientists say they are making collaborations harder.

doi: 10.1038/d41586-022-01230-z

This Arctic town wants to make renewable energy work at the top of the world p.406

Partnering with a northern settlement in Greenland, researchers are designing wind and solar devices that can survive and thrive in extreme conditions.

doi: 10.1038/d41586-022-01189-x

Coronavirus ‘ghosts’ found lingering in the gut p.408

Scientists are studying whether long COVID could be linked to viral fragments found in the body months after initial infection.

doi: 10.1038/d41586-022-01280-3

Origin of life theory involving RNA–protein hybrid gets new support p.409

Structure that links amino acids suggests that early organisms could have been based on an RNA–protein mix.

doi: 10.1038/d41586-022-01303-z

The pandemic’s true health cost: how much of our lives has COVID stolen? p.410

doi: 10.1038/d41586-022-01341-7

How three Ukrainian scientists are surviving Russia’s brutal war p.414

doi: 10.1038/d41586-022-01272-3

Giant collision created galaxies devoid of dark matter p.427

Two galaxies that are curiously lacking in dark matter — the most abundant matter in the Universe — might have formed when a collision between dwarf galaxies separated ordinary matter from its dark counterpart.

doi: 10.1038/d41586-022-01298-7

Young cerebrospinal fluid improves memory in old mice p.428

Infusion of cerebrospinal fluid from young mice into old mice restores memory recall in the aged animals by triggering production of the fatty myelin sheath that insulates neurons in the brain.

doi: 10.1038/d41586-022-00860-7

A lab-on-a-chip that takes the chip out of the lab p.429

A microfluidic system achieves miniaturization without the need for extra equipment, bringing chip-based devices closer to mainstream commercial reality, with a framework that could be widely applied to diagnostics.

doi: 10.1038/d41586-022-01299-6

Killing the messenger to evade bacterial defences p.431

Many mysteries remain about how antiviral responses shape the ability of viruses to infect bacteria. The finding that viruses interfere with signalling mediated by molecules called second messengers sheds light on bacterial defences.

doi: 10.1038/d41586-022-01127-x

Tension hones body segmentation around the clock p.432

The formation of body segments in vertebrate embryos has long been attributed to the spatio-temporal patterning of molecular signals. But segment length in zebrafish is now found to be adjusted by tissue mechanics.

doi: 10.1038/d41586-022-00840-x

A trail of dark-matter-free galaxies from a bullet-dwarf collision p.435

doi: 10.1038/s41586-022-04665-6

Direct observation of the dead-cone effect in quantum chromodynamics p.440

doi: 10.1038/s41586-022-04572-w

Polariton Bose–Einstein condensate from a bound state in the continuum p.447

doi: 10.1038/s41586-022-04583-7

Observation of a molecular bond between ions and Rydberg atoms p.453

doi: 10.1038/s41586-022-04577-5

Microcomb-driven silicon photonic systems p.457

doi: 10.1038/s41586-022-04579-3

Microfluidic chain reaction of structurally programmed capillary flow events p.464

doi: 10.1038/s41586-022-04683-4

Programmable heating and quenching for efficient thermochemical synthesis p.470

doi: 10.1038/s41586-022-04568-6

σ]-photocycloaddition enabled by triplet energy transfer" rel="external">Intermolecular [2π+2σ]-photocycloaddition enabled by triplet energy transfer p.477

doi: 10.1038/s41586-022-04636-x

Synergistic HNO₃–H₂SO₄–NH₃ upper tropospheric particle formation p.483

doi: 10.1038/s41586-022-04605-4

Expanding ocean food production under climate change p.490

doi: 10.1038/s41586-022-04674-5

A natural mutator allele shapes mutation spectrum variation in mice p.497

doi: 10.1038/s41586-022-04701-5

Genetic and chemotherapeutic influences on germline hypermutation p.503

doi: 10.1038/s41586-022-04712-2

Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17 p.509

doi: 10.1038/s41586-022-04722-0

Left–right symmetry of zebrafish embryos requires somite surface tension p.516

doi: 10.1038/s41586-022-04646-9

Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity p.522

doi: 10.1038/s41586-022-04716-y

Group A Streptococcus induces GSDMA-dependent pyroptosis in keratinocytes p.527

doi: 10.1038/s41586-022-04717-x

Landscape of helper and regulatory antitumour CD4+ T cells in melanoma p.532

doi: 10.1038/s41586-022-04682-5

Selective inhibition of miRNA processing by a herpesvirus-encoded miRNA p.539

doi: 10.1038/s41586-022-04667-4

Nonlinear mechanics of human mitotic chromosomes p.545

doi: 10.1038/s41586-022-04666-5

Design of protein-binding proteins from the target structure alone p.551

doi: 10.1038/s41586-022-04654-9

Structural basis of NPR1 in activating plant immunity p.561

doi: 10.1038/s41586-022-04699-w

USP14-regulated allostery of the human proteasome by time-resolved cryo-EM p.567

doi: 10.1038/s41586-022-04671-8