Employers can make remote working a success by listening to research p.597

Virtual working is here to stay. Research can guide employers to enhance creativity online.

doi: 10.1038/d41586-022-01044-z

Chemistry education must change to help the planet: here’s how p.598

The subject has a history in heavy industry and fossil fuels, but teachers should focus on sustainability and climate science.

doi: 10.1038/d41586-022-01109-z

Are new Omicron subvariants a threat? Here’s how scientists are keeping watch p.605

In South Africa, a network of researchers is studying whether lineages BA.4 and BA.5 escape immunity from COVID-19 vaccines and previous infections.

doi: 10.1038/d41586-022-01069-4

Next stop, Uranus? Icy planet tops priority list for next big NASA mission p.607

Influential panel’s recommendation makes the ice giant a likely destination for a flagship space mission.

doi: 10.1038/d41586-022-01087-2

Biotech firm announces results from first US trial of genetically modified mosquitoes p.608

Oxitec reports that its insects behaved as planned — but a larger trial is needed to learn whether they can reduce wild mosquito populations.

doi: 10.1038/d41586-022-01070-x

Trove of tumour genomes offers clues to cancer origins p.609

Largest-ever study uncovers patterns of mutations that might pinpoint cancer’s causes.

doi: 10.1038/d41586-022-01095-2

Record-breaking simulation hints at how climate shaped human migration p.610

Model suggests that a shift in weather patterns in southern Africa might have contributed to the rise of Homo sapiens.

doi: 10.1038/d41586-022-01050-1

Macron win relieves French researchers p.611

Scientists cheer for the defeat of far-right candidate Marine Le Pen, but say President Emmanuel Macron’s plans for research are vague.

doi: 10.1038/d41586-022-01165-5

COVID is spreading in deer. What does that mean for the pandemic? p.612

doi: 10.1038/d41586-022-01112-4

Jumping robot bests biology by enhancing stored energy p.627

A robotic jumper combines inspiration from biology with clever engineering to reach new heights. Crucial to the design is the combination of a rotary motor with a hybrid spring that maximizes stored energy density.

doi: 10.1038/d41586-022-01077-4

Self-activated adhesion receptor proteins visualized p.628

The inner workings of a family of proteins, known as adhesion G-protein-coupled receptors, have finally been visualized at high resolution — revealing the structural basis of their self-activation mechanism.

doi: 10.1038/d41586-022-00972-0

A colourful view of the origin of dinosaur feathers p.630

Birds and their dinosaur ancestors had feathers, and now it seems that a distantly related group called pterosaurs had them, too. The finding extends the origins of feathers back to long before birds evolved, and sheds light on their role.

doi: 10.1038/d41586-022-01036-z

Tailor-made enzymes poised to propel plastic recycling into a new era p.631

Waste streams of the plastic poly(ethylene terephthalate) that can be recycled into material suitable for food packaging are limited, creating a shortfall of feedstocks. An enzyme has been discovered that widens the feedstock options.

doi: 10.1038/d41586-022-01075-6

Brain changes after COVID revealed by imaging p.633

Imaging before and after infection by the SARS-CoV-2 virus reveals substantial changes in the brain after infection. The work sets an example for the high standards required in large longitudinal neuroimaging studies.

doi: 10.1038/d41586-022-00503-x

FAIR data enabling new horizons for materials research p.635

doi: 10.1038/s41586-022-04501-x

Early Solar System instability triggered by dispersal of the gaseous disk p.643

doi: 10.1038/s41586-022-04535-1

Observation of a linked-loop quantum state in a topological magnet p.647

doi: 10.1038/s41586-022-04512-8

The field-free Josephson diode in a van der Waals heterostructure p.653

doi: 10.1038/s41586-022-04504-8

Engineered jumpers overcome biological limits via work multiplication p.657

doi: 10.1038/s41586-022-04606-3

Machine learning-aided engineering of hydrolases for PET depolymerization p.662

doi: 10.1038/s41586-022-04599-z

Computer-designed repurposing of chemical wastes into drugs p.668

doi: 10.1038/s41586-022-04503-9

Catalytic synthesis of phenols with nitrous oxide p.677

doi: 10.1038/s41586-022-04516-4

Pterosaur melanosomes support signalling functions for early feathers p.684

doi: 10.1038/s41586-022-04622-3

Somatic mosaicism reveals clonal distributions of neocortical development p.689

doi: 10.1038/s41586-022-04602-7

SARS-CoV-2 is associated with changes in brain structure in UK Biobank p.697

doi: 10.1038/s41586-022-04569-5

Modulation of inhibitory communication coordinates looking and reaching p.708

doi: 10.1038/s41586-022-04631-2

Somatic genomic changes in single Alzheimer’s disease neurons p.714

doi: 10.1038/s41586-022-04640-1

Cell transcriptomic atlas of the non-human primate Macaca fascicularis p.723

doi: 10.1038/s41586-022-04587-3

Environmental factors shaping the gut microbiome in a Dutch population p.732

doi: 10.1038/s41586-022-04567-7

Specification of CNS macrophage subsets occurs postnatally in defined niches p.740

doi: 10.1038/s41586-022-04596-2

CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition p.749

doi: 10.1038/s41586-022-04638-9

The tethered peptide activation mechanism of adhesion GPCRs p.757

doi: 10.1038/s41586-022-04575-7

Structural basis for the tethered peptide activation of adhesion GPCRs p.763

doi: 10.1038/s41586-022-04619-y

Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4 p.771

doi: 10.1038/s41586-022-04590-8

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1 p.779

doi: 10.1038/s41586-022-04580-w