p.7

COP26 energized the global effort to halt global warming. Research is now crucial to monitoring progress and creating solutions.

doi: 10.1038/d41586-021-03817-4

p.11

Research has stalled, funds have evaporated and many scientists are still struggling to get out.

doi: 10.1038/d41586-021-03774-y

p.12

Hundreds of engineering steps must now take place as the observatory unfurls and travels to its new home.

doi: 10.1038/d41586-021-03655-4

p.14

A few publishers are using automated software to catch flaws in submitted papers.

doi: 10.1038/d41586-021-03807-6

p.16

Omicron, Moon missions and particle physics are among the themes set to shape research in the coming year.

doi: 10.1038/d41586-021-03772-0

p.18

doi: 10.1038/d41586-021-03819-2

p.27

Analysis of plankton fossils has revealed pulses of size diversity that are inextricably linked to the degree of circularity of Earth’s orbits. Could this orbital variability provide a beat that dictates the rhythm of evolution?

doi: 10.1038/d41586-021-03549-5

p.29

In some neurodegenerative diseases, a protein called TDP-43 forms aggregates in the brain, resulting in neuronal cell death. The structure of these aggregates and their properties have been unveiled.

doi: 10.1038/d41586-021-03605-0

p.31

Treatment for leukaemia can fail for reasons that are not fully clear. Tracking the progress of individual cellular lineages for this type of cancer offers a way to investigate this phenomenon.

doi: 10.1038/d41586-021-03606-z

p.32

A comparison of the charge-to-mass ratio for the proton and the antiproton has been performed with record-breaking precision — the best such test yet for a mirror-like symmetry that relates matter and antimatter.

doi: 10.1038/d41586-021-03798-4

p.35

doi: 10.1038/s41586-021-04073-2

p.45

doi: 10.1038/s41586-021-04162-2

p.49

doi: 10.1038/s41586-021-04159-x

p.53

doi: 10.1038/s41586-021-04203-w

p.58

doi: 10.1038/s41586-021-04170-2

p.63

doi: 10.1038/s41586-021-04174-y

p.69

doi: 10.1038/s41586-021-04157-z

p.74

doi: 10.1038/s41586-021-04222-7

p.79

doi: 10.1038/s41586-021-04195-7

p.85

doi: 10.1038/s41586-021-04217-4

p.92

doi: 10.1038/s41586-021-04067-0

p.98

doi: 10.1038/s41586-021-04191-x

p.105

doi: 10.1038/s41586-021-04169-9

p.110

doi: 10.1038/s41586-021-04186-8

p.118

doi: 10.1038/s41586-021-04221-8

p.125

doi: 10.1038/s41586-021-04206-7

p.132

doi: 10.1038/s41586-021-04204-9

p.139

doi: 10.1038/s41586-021-04199-3

p.144

doi: 10.1038/s41586-021-04225-4