The next 20 years of human genomics must be more equitable and more open p.183

By re-committing to data sharing, researchers can fulfil the long-delayed promise of the Human Genome Project.

doi: 10.1038/d41586-021-00328-0

India must protect the independence of its landmark science agency p.184

The new science-funding agency will allow many thousands of university researchers to develop their talents. Its architects must work with the government to ensure it is truly autonomous.

doi: 10.1038/d41586-021-00327-1

What’s the risk of dying from a fast-spreading COVID-19 variant? p.191

Deaths linked to the B.1.1.7 variant are rising, but questions remain about what is causing them.

doi: 10.1038/d41586-021-00299-2

Tracking QAnon: how Trump turned conspiracy-theory research upside down p.192

By taking fringe ideas mainstream, the former US president taught new and dangerous lessons about manipulating social and mass media.

doi: 10.1038/d41586-021-00257-y

COVID’s mental-health toll: how scientists are tracking a surge in depression p.194

Researchers are using huge data sets to link changes in mental health to coronavirus-response measures.

doi: 10.1038/d41586-021-00175-z

Scientists call for fully open sharing of coronavirus genome data p.195

Other researchers say that restrictions at the largest SARS-CoV-2 genome platform encourage fast sharing while protecting data providers’ rights.

doi: 10.1038/d41586-021-00305-7

AI maths whiz creates tough new problems for humans to solve p.196

Algorithm named after mathematician Srinivasa Ramanujan suggests interesting formulae, some of which are difficult to prove true.

doi: 10.1038/d41586-021-00304-8

Vaccines are curbing COVID: Data from Israel show drop in infections p.197

The country is the first to see a direct effect of vaccines working in such a large group of people.

doi: 10.1038/d41586-021-00316-4

The broken promise that undermines human genome research p.198

doi: 10.1038/d41586-021-00331-5

Rapid coronavirus tests: a guide for the perplexed p.202

doi: 10.1038/d41586-021-00332-4

Breaking through the unknowns of the human reference genome p.217

Since the human genome was published in 2001, many of the gaps in the original sequence have been filled in, offering a more detailed understanding of genome regulation, structure and function.

doi: 10.1038/d41586-021-00293-8

How the human genome transformed study of rare diseases p.218

Mendelian diseases are caused by mutations in a single gene. The first draft of the human genome, published in 2001, had broad implications for how these diseases are diagnosed, managed and prevented.

doi: 10.1038/d41586-021-00294-7

From one human genome to a complex tapestry of ancestry p.220

In the 20 years since the first drafts of the human genome were made public, an explosion in genome sequencing has revealed how our evolutionary history and health can be understood by analysing the diversity in our genomes.

doi: 10.1038/d41586-021-00237-2

New-found brake calibrates insulin action in β-cells p.221

Insulin is produced by pancreatic β-cells. The identification of a regulator of insulin signalling in these cells cements the long-standing idea that this pathway has a key role in β-cell biology.

doi: 10.1038/d41586-021-00141-9

Neuroprosthetic device maintains blood pressure after spinal cord injury p.223

The inability to maintain blood pressure is a debilitating consequence of spinal cord injury. This problem has now been circumvented, by artificially recreating a reflex essential for blood-pressure stability.

doi: 10.1038/d41586-021-00087-y

Lend an ear to a classic tale of mammalian evolution p.224

Newly discovered fossil evidence has led to a re-evaluation of one of the fundamental transitions in mammalian evolution: the transformation of bones of the lower jaw into those of the middle ear.

doi: 10.1038/d41586-021-00064-5

Shedding squeezed light on dark matter p.226

Hypothetical particles called axions could constitute dark matter — the unseen component of the Universe. An experiment shows how quantum-manipulation technology can improve the sensitivity of axion detectors.

doi: 10.1038/d41586-021-00295-6

Origins of modern human ancestry p.229

doi: 10.1038/s41586-021-03244-5

A quantum enhanced search for dark matter axions p.238

doi: 10.1038/s41586-021-03226-7

Protecting a bosonic qubit with autonomous quantum error correction p.243

doi: 10.1038/s41586-021-03257-0

Tunable strongly coupled superconductivity in magic-angle twisted trilayer graphene p.249

doi: 10.1038/s41586-021-03192-0

A universal 3D imaging sensor on a silicon photonics platform p.256

doi: 10.1038/s41586-021-03259-y

Facile route to bulk ultrafine-grain steels for high strength and ductility p.262

doi: 10.1038/s41586-021-03246-3

Thermally reconfigurable monoclinic nematic colloidal fluids p.268

doi: 10.1038/s41586-021-03249-0

Complex structures arising from the self-assembly of a simple organic salt p.275

doi: 10.1038/s41586-021-03194-y

A monotreme-like auditory apparatus in a Middle Jurassic haramiyidan p.279

doi: 10.1038/s41586-020-03137-z

Giant lungfish genome elucidates the conquest of land by vertebrates p.284

doi: 10.1038/s41586-021-03198-8

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program p.290

doi: 10.1038/s41586-021-03205-y

Regulatory genomic circuitry of human disease loci by integrative epigenomics p.300

doi: 10.1038/s41586-020-03145-z

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury p.308

doi: 10.1038/s41586-020-03180-w

Antidepressant actions of ketamine engage cell-specific translation via eIF4E p.315

doi: 10.1038/s41586-020-03047-0

A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate p.320

doi: 10.1038/s41586-020-3035-9

Inceptor counteracts insulin signalling in β-cells to control glycaemia p.326

doi: 10.1038/s41586-021-03225-8

Anti-tumour immunity induces aberrant peptide presentation in melanoma p.332

doi: 10.1038/s41586-020-03054-1

Loop extrusion mediates physiological Igh locus contraction for RAG scanning p.338

doi: 10.1038/s41586-020-03121-7

Integrated spatial genomics reveals global architecture of single nuclei p.344

doi: 10.1038/s41586-020-03126-2