Volume 587 Issue 7835



News Features

News & Views

Neutrino detection gets to the core of the Sun p.550

The first detection of neutrinos produced by the Sun’s secondary solar-fusion cycle paves the way for a detailed understanding of the structure of the Sun and of the formation of massive stars.

doi: 10.1038/d41586-020-03238-9

Neanderthal DNA highlights complexity of COVID risk factors p.552

A genetic analysis reveals that some people who have severe reactions to the SARS-CoV-2 virus inherited certain sections of their DNA from Neanderthals. However, our ancestors can’t take all the blame for how someone responds to the virus.

doi: 10.1038/d41586-020-02957-3

Isoforms of GPCR proteins combine for diverse signalling p.553

Many receptor proteins of the GPCR family exist in multiple isoforms. A comprehensive analysis of different combinations of GPCR isoforms that produce diverse signalling patterns in cells has implications for drug development.

doi: 10.1038/d41586-020-03001-0



Structural mechanism of cGAS inhibition by the nucleosome p.668

Using cryo-electron microscopy, the authors determine the structure of cGAS bound to nucleosomes and present evidence for the mechanism by which nucleosome binding to cGAS prevents cGAS dimerization and its binding to free double-stranded DNA.

doi: 10.1038/s41586-020-2750-6