Volume 577 Issue 7788



News Features

News & Views

Tuberculosis vaccine finds an improved route p.31

A widely used vaccine against tuberculosis has now been shown to provide almost complete protection when injected intravenously. This is a striking improvement over vaccination through the typical intradermal route.

doi: 10.1038/d41586-019-03597-y

Food for thought about manipulating gut bacteria p.32

Knowing how dietary fibre nourishes gut microorganisms might suggest ways to boost health-promoting bacteria. A method developed to pinpoint bacteria that consume particular types of dietary fibre could advance such efforts.

doi: 10.1038/d41586-019-03704-z

Infrared spectroscopy finally sees the light p.34

The reliance of infrared spectroscopy on light transmission limits the sensitivity of many analytical applications. An approach that depends on the emission of infrared radiation from molecules promises to solve this problem.

doi: 10.1038/d41586-019-03866-w

AI shows promise for breast cancer screening p.35

Could artificial intelligence improve the accuracy of screening for breast cancer? A comparison of the diagnostic performance of expert physicians and computers suggests so, but the clinical implications are as yet uncertain.

doi: 10.1038/d41586-019-03822-8

Galaxy cluster illuminates the cosmic dark ages p.36

Observations of a distant cluster of galaxies suggest that star formation began there only 370 million years after the Big Bang. The results provide key details about where and when the first stars and galaxies emerged in the Universe.

doi: 10.1038/d41586-019-03893-7


RGF1 controls root meristem size through ROS signalling p.85

RITF1, a newly identified plant transcription factor, links signalling through the peptide hormone RGF1 to the balance of reactive oxygen species and thereby enhances the stability of another transcription factor, PLETHORA2, a master regulator of root stem cells.

doi: 10.1038/s41586-019-1819-6

Regulation of α-synuclein by chaperones in mammalian cells p.127

Chaperones interact with a canonical motif in α-synuclein, which can be prevented by phosphorylation of α-synuclein at Tyr39, whereas inhibition of this interaction leads to the localization of α-synuclein to the mitochondria and aggregate formation.

doi: 10.1038/s41586-019-1808-9