Climate talks must chart an equitable path to net-zero emissions p.7

doi: 10.1038/d41586-019-03708-9

Expensive treatments for genetic disorders are arriving. But who should foot the bill? p.7

doi: 10.1038/d41586-019-03709-8

Parker probe kicks off a golden age for solar exploration p.8

doi: 10.1038/d41586-019-03710-1

Sun-bombing spacecraft uncovers secrets of the solar wind p.15

doi: 10.1038/d41586-019-03684-0

Chinese ministry investigates duplications in papers by university president p.16

Four journals also say they are scrutinizing papers coauthored by Cao Xuetao after scientists raise questions about images on Twitter and PubPeer.

doi: 10.1038/d41586-019-03599-w

Carbon markets shape agenda at UN climate summit p.17

The COP25 discussions also face a backdrop of uncertain geopolitics and intensifying public pressure.

doi: 10.1038/d41586-019-03695-x

Targeted stem-cell attack could make transplants safer p.18

Blood stem-cell transplants show promise for treating genetic and immune disorders, as well as cancers, but are currently risky.

doi: 10.1038/d41586-019-03601-5

E. coli bacteria engineered to eat carbon dioxide p.19

Feat could turn bacteria into biological factories for energy and even food.

doi: 10.1038/d41586-019-03679-x

Gene therapy is facing its biggest challenge yet p.22

doi: 10.1038/d41586-019-03698-8

Did a million years of rain jump-start dinosaur evolution? p.26

doi: 10.1038/d41586-019-03699-7

Designer alloy enables 3D printing of fine-grained metals p.41

doi: 10.1038/d41586-019-03701-2

How a fly’s neural compass adapts to an ever-changing world p.42

Two studies in flies reveal the mechanism by which the brain’s directional system learns to align information about self-orientation with environmental landmarks — a process crucial for accurate navigation.

doi: 10.1038/d41586-019-03443-1

All ears about ancient mammals p.44

The configuration of middle-ear bones in an ancient fossil suggests that specializations suited to eating plants might have influenced how the jaw joint evolved to form the mammal’s ear.

doi: 10.1038/d41586-019-03605-1

Electrons in graphene go with the flow p.45

doi: 10.1038/d41586-019-03702-1

Cell-tracking pipeline reveals how motor circuits are built p.46

A sophisticated imaging pipeline has been developed to track neurons in early-stage zebrafish embryos over time and space. It reveals how newborn neurons come together to build a spinal cord capable of locomotion.

doi: 10.1038/d41586-019-03492-6

CRISPR tool modifies genes precisely by copying RNA into the genome p.48

The ultimate goal of genome editing is to be able to make any specific change to the blueprint of life. A ‘search-and-replace’ method for genome editing takes us a giant leap closer to this ambitious goal.

doi: 10.1038/d41586-019-03392-9

The integrative biology of type 2 diabetes p.51

doi: 10.1038/s41586-019-1797-8

Accretion of a giant planet onto a white dwarf star p.61

doi: 10.1038/s41586-019-1789-8

Observation of the exceptional-point-enhanced Sagnac effect p.65

doi: 10.1038/s41586-019-1777-z

Non-Hermitian ring laser gyroscopes with enhanced Sagnac sensitivity p.70

doi: 10.1038/s41586-019-1780-4

Visualizing Poiseuille flow of hydrodynamic electrons p.75

doi: 10.1038/s41586-019-1788-9

Interlayer exciton laser of extended spatial coherence in atomically thin heterostructures p.80

doi: 10.1038/s41586-019-1779-x

Thermoelectric performance of a metastable thin-film Heusler alloy p.85

doi: 10.1038/s41586-019-1751-9

Additive manufacturing of ultrafine-grained high-strength titanium alloys p.91

doi: 10.1038/s41586-019-1783-1

Upper-plate rigidity determines depth-varying rupture behaviour of megathrust earthquakes p.96

doi: 10.1038/s41586-019-1784-0

Cretaceous fossil reveals a new pattern in mammalian middle ear evolution p.102

doi: 10.1038/s41586-019-1792-0

The GenomeAsia 100K Project enables genetic discoveries across Asia p.106

doi: 10.1038/s41586-019-1793-z

Longitudinal molecular trajectories of diffuse glioma in adults p.112

doi: 10.1038/s41586-019-1775-1

Sensorimotor experience remaps visual input to a heading-direction network p.121

doi: 10.1038/s41586-019-1772-4

Generation of stable heading representations in diverse visual scenes p.126

doi: 10.1038/s41586-019-1767-1

Gene expression cartography p.132

doi: 10.1038/s41586-019-1773-3

PGRMC2 is an intracellular haem chaperone critical for adipocyte function p.138

doi: 10.1038/s41586-019-1774-2

Bile acid metabolites control T_H17 and T_reg cell differentiation p.143

doi: 10.1038/s41586-019-1785-z

Search-and-replace genome editing without double-strand breaks or donor DNA p.149

doi: 10.1038/s41586-019-1711-4

Chromatin structure dynamics during the mitosis-to-G1 phase transition p.158

doi: 10.1038/s41586-019-1778-y

The structures and gating mechanism of human calcium homeostasis modulator 2 p.163

doi: 10.1038/s41586-019-1781-3