Volume 575 Number 7781



News Features

News & Views

The structure of DNA p.35

In the early 1950s, the identity of genetic material was still a matter of debate. The discovery of the helical structure of double-stranded DNA settled the matter — and changed biology forever.

doi: 10.1038/d41586-019-02554-z

Detection of a strange particle p.36

In 1947, scientists found a previously unseen particle, which is now called a neutral kaon. This work led to the discovery of elementary particles known as quarks, and ultimately to the establishment of the standard model of particle physics.

doi: 10.1038/d41586-019-02841-9

Birth of a class of nanomaterial p.40

Nearly 30 years ago, a simple chemical principle was reported that enabled the synthesis of a plethora of porous materials — some of which might enable applications ranging from biomedicine to petrochemical processing.

doi: 10.1038/d41586-019-02835-7

How Australopithecus provided insight into human evolution p.41

In 1925, a Nature paper reported an African fossil of a previously unknown genus called Australopithecus. This finding revolutionized ideas about early human evolution after human ancestors and apes split on the evolutionary tree.

doi: 10.1038/d41586-019-02839-3

First exoplanet found around a Sun-like star p.43

In 1995, astronomers detected a blisteringly hot Jupiter-mass planet orbiting closer to its host star than Mercury is to the Sun. This discovery recast our thinking of how planets form and led to a new era of exoplanetary exploration.

doi: 10.1038/d41586-019-02553-0

Cell identity reprogrammed p.44

The discovery that cell differentiation can be reversed challenged theories of how cell identity is determined, laying the foundations for modern methods of reprogramming cell identity and promising new regenerative therapies.

doi: 10.1038/d41586-019-02834-8

The discovery of the Antarctic ozone hole p.46

The unexpected discovery of a hole in the atmospheric ozone layer over the Antarctic revolutionized science — and helped to establish one of the most successful global environmental policies of the twentieth century.

doi: 10.1038/d41586-019-02837-5

The advent and rise of monoclonal antibodies p.47

A 1975 Nature paper reported how cell lines could be made that produce an antibody of known specificity. This discovery led to major biological insights and clinical successes in treating autoimmunity and cancer.

doi: 10.1038/d41586-019-02840-w

The nano-revolution spawned by carbon p.49

In 1985, scientists reported the discovery of the cage-like carbon molecule C60. The finding paved the way for materials such as graphene and carbon nanotubes, and was a landmark in the emergence of nanotechnology.

doi: 10.1038/d41586-019-02838-4

Huge whole-genome study of human metastatic cancers p.60

A better understanding of the genetic changes that enable cancers to spread is crucial. A comprehensive study of whole-genome sequences from metastatic cancer will help researchers to achieve this goal.

doi: 10.1038/d41586-019-03123-0