The Chinese Academy of Sciences at 70 p.5

Over the past few decades, the academy’s investments have made it one of the world’s richest. Could its financial autonomy be a model for others?

doi: 10.1038/d41586-019-02950-5

A kinder research culture is possible p.5

Wellcome is right to call out hyper-competitiveness in research and question the focus on excellence. But other funders must follow its move.

doi: 10.1038/d41586-019-02951-4

Let fishers in Africa and Asia keep more of their catches p.6

doi: 10.1038/d41586-019-02962-1

How US sanctions are crippling science in Iran p.13

Besieged researchers say that currency collapse, scientific isolation and psychological strain are hindering almost every aspect of their work.

doi: 10.1038/d41586-019-02795-y

CRISPR might be the banana’s only hope against a deadly fungus p.15

Researchers are using the gene-editing tool to boost the fruit’s defences and prevent the extinction of a major commercial variety.

doi: 10.1038/d41586-019-02770-7

India pushes for alternatives to animals in biomedical research p.16

Organs-on-a-chip and other technologies are becoming reliable models for testing drug efficacy and toxicity.

doi: 10.1038/d41586-019-02947-0

Gigantic Chinese telescope opens to astronomers worldwide p.16

FAST has superior sensitivity to detect cosmic phenomena, including fast radio bursts and pulsars.

doi: 10.1038/d41586-019-02790-3

World’s oceans are losing power to stall climate change p.17

United Nations report predicts more powerful storms, increased risk of flooding and dwindling fisheries if greenhouse-gas output doesn’t fall.

doi: 10.1038/d41586-019-02897-7

Beyond quantum supremacy: the hunt for useful quantum computers p.19

doi: 10.1038/d41586-019-02936-3

Quantum gold rush: the private funding pouring into quantum start-ups p.22

doi: 10.1038/d41586-019-02935-4

Leapfrog to speciation boosted by mother’s influence p.38

doi: 10.1038/d41586-019-02904-x

Two-dimensional semiconductors host high-temperature exotic state p.39

doi: 10.1038/d41586-019-02906-9

How the global fish market contributes to human micronutrient deficiencies p.41

Analysis of the nutrient composition of fish caught around the globe reveals locations where the retention of fish for consumption by local populations could help to tackle human disease caused by nutrient deficiencies.

doi: 10.1038/d41586-019-02810-2

Double-click enables synthesis of chemical libraries for drug discovery p.42

doi: 10.1038/d41586-019-02905-w

Flies’ colour preferences depend on the time of day p.43

Behavioural and genetic experiments have revealed that fruit flies prefer green light over other colours in the morning and evening, and always avoid blue. These colour preferences rely on different mechanisms.

doi: 10.1038/d41586-019-02745-8

Harnessing innate immunity in cancer therapy p.45

doi: 10.1038/s41586-019-1593-5

FPR1 is the plague receptor on host immune cells p.57

doi: 10.1038/s41586-019-1570-z

Treatment of type 2 diabetes with the designer cytokine IC7Fc p.63

doi: 10.1038/s41586-019-1601-9

Two major accretion epochs in M31 from two distinct populations of globular clusters p.69

doi: 10.1038/s41586-019-1597-1

Constraints on the superconducting order parameter in Sr₂RuO₄ from oxygen-17 nuclear magnetic resonance p.72

doi: 10.1038/s41586-019-1596-2

Evidence of high-temperature exciton condensation in two-dimensional atomic double layers p.76

doi: 10.1038/s41586-019-1591-7

PdMo bimetallene for oxygen reduction catalysis p.81

doi: 10.1038/s41586-019-1603-7

Modular click chemistry libraries for functional screens using a diazotizing reagent p.86

doi: 10.1038/s41586-019-1589-1

Environmental flow limits to global groundwater pumping p.90

doi: 10.1038/s41586-019-1594-4

Harnessing global fisheries to tackle micronutrient deficiencies p.95

doi: 10.1038/s41586-019-1592-6

Imprinting sets the stage for speciation p.99

doi: 10.1038/s41586-019-1599-z

Early Pleistocene enamel proteome from Dmanisi resolves Stephanorhinus phylogeny p.103

doi: 10.1038/s41586-019-1555-y

Daytime colour preference in Drosophila depends on the circadian clock and TRP channels p.108

doi: 10.1038/s41586-019-1571-y

Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary p.112

doi: 10.1038/s41586-019-1598-0

Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth p.117

doi: 10.1038/s41586-019-1560-1

Analysis of the B cell receptor repertoire in six immune-mediated diseases p.122

doi: 10.1038/s41586-019-1595-3

The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs p.127

doi: 10.1038/s41586-019-1600-x

Crystal structure of heliorhodopsin p.132

doi: 10.1038/s41586-019-1604-6