Volume 570 Number 7760


Act now on CRISPR babies p.137

Another researcher has announced controversial plans to gene edit babies. The scientific community must intervene.

doi: 10.1038/d41586-019-01786-3


News Features

News & Views

Two types of fibroblast drive arthritis p.169

Fibroblast cells promote the development of rheumatoid arthritis. The finding that two distinct fibroblast populations affect different aspects of the disease in mice has implications for efforts to develop clinical treatments.

doi: 10.1038/d41586-019-01594-9

Catalytic machinery of enzymes expanded p.172

Only a few types of natural amino-acid residue are used directly by enzymes to catalyse reactions. The incorporation of an unnatural residue into an enzyme shows how the catalytic repertoire of enzymes can be enlarged.

doi: 10.1038/d41586-019-01596-7

Bacterial dormancy curbs phage epidemics p.173

One type of CRISPR–Cas bacterial-defence system destroys phage and bacterial RNA, which leads to bacterial dormancy. Dormancy is found to limit viral spread, and also protects against unrelated viruses and viral mutants.

doi: 10.1038/d41586-019-01595-8