It’s time to talk about ditching statistical significance p.283

doi: 10.1038/d41586-019-00874-8

Spraying diseased citrus orchards with antibiotics could backfire p.283

Florida’s efforts to combat citrus greening with widespread drugs could harm the environment and public health.

doi: 10.1038/d41586-019-00875-7

Thousands of scientists are backing the kids striking for climate change p.291

Students around the world are walking out of school to urge governments to do more about global warming.

doi: 10.1038/d41586-019-00861-z

Bull ‘super dads’ are being engineered to produce sperm from another father p.292

Gene-edited ‘surrogate sires’ could help spread desirable traits rapidly in some livestock.

doi: 10.1038/d41586-019-00718-5

Scientists track damage from controversial deep-sea mining method p.294

Researchers will monitor the environmental effects of an industrial test to extract valuable metals from the Pacific sea floor.

doi: 10.1038/d41586-019-00757-y

English sea walls get wired to measure flood risk in real time p.294

On the shores of Liverpool Bay, ‘WireWall’ device helps engineers mount a battle against the waves.

doi: 10.1038/d41586-019-00720-x

Soap-bubble pioneer is first woman to win prestigious maths prize p.295

Abel-prize winner Karen Keskulla Uhlenbeck built bridges between analysis, geometry and physics.

doi: 10.1038/d41586-019-00932-1

Protein-slaying drugs could be the next blockbuster therapies p.298

doi: 10.1038/d41586-019-00879-3

Antibiotics set to flood Florida’s troubled orange orchards p.302

doi: 10.1038/d41586-019-00878-4

Robotic collectives inspired by biological cells p.314

doi: 10.1038/d41586-019-00839-x

Pore-forming small molecules offer a promising way to tackle cystic fibrosis p.315

In cystic fibrosis, ion-transport abnormalities cause problems in many organs. A small molecule that forms cell-membrane pores allowing ion transport shows therapeutic promise in human cells and a model of the disease.

doi: 10.1038/d41586-019-00781-y

Enzymes trapped and zapped for use outside cells p.317

Many enzymes cooperate with other proteins and small molecules to function. A strategy that mimics the confinement of such cooperative partners in cells might allow these enzymes to be used in applications outside biological systems.

doi: 10.1038/d41586-019-00761-2

X-ray chimneys in the Galactic Centre p.318

doi: 10.1038/d41586-019-00811-9

The influence of a single neuron on its network p.320

The contribution of a single neuron to brain function might seem negligible. But a map of the influence of single neurons reveals a complex pattern that prevents redundancy and enables clear messaging.

doi: 10.1038/d41586-019-00687-9

Structures of STING protein illuminate this key regulator of inflammation p.321

The STING protein aids intracellular defences by triggering inflammation. Studies that uncover how STING is activated might lead to strategies for targeting this protein in the treatment of cancer or autoimmune diseases.

doi: 10.1038/d41586-019-00707-8

Van der Waals integration before and beyond two-dimensional materials p.323

doi: 10.1038/s41586-019-1013-x

Single-neuron perturbations reveal feature-specific competition in V1 p.334

doi: 10.1038/s41586-019-0997-6

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma p.341

doi: 10.1038/s41586-019-0993-x

An X-ray chimney extending hundreds of parsecs above and below the Galactic Centre p.347

doi: 10.1038/s41586-019-1009-6

Random anti-lasing through coherent perfect absorption in a disordered medium p.351

doi: 10.1038/s41586-019-0971-3

Photonic topological insulator in synthetic dimensions p.356

doi: 10.1038/s41586-019-0943-7

Particle robotics based on statistical mechanics of loosely coupled components p.361

doi: 10.1038/s41586-019-1022-9

Diverse and robust molecular algorithms using reprogrammable DNA self-assembly p.366

doi: 10.1038/s41586-019-1014-9

Deacylative transformations of ketones via aromatization-promoted C–C bond activation p.373

doi: 10.1038/s41586-019-0926-8

Deep electrical imaging of the ultraslow-spreading Mohns Ridge p.379

doi: 10.1038/s41586-019-1010-0

Feature-selective encoding of substrate vibrations in the forelimb somatosensory cortex p.384

doi: 10.1038/s41586-019-1015-8

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP p.389

doi: 10.1038/s41586-019-0998-5

Structural basis of STING binding with and phosphorylation by TBK1 p.394

doi: 10.1038/s41586-019-1000-2

Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups p.399

doi: 10.1038/s41586-019-1007-8

Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia p.405

doi: 10.1038/s41586-019-1018-5

Mechanism of DNA translocation underlying chromatin remodelling by Snf2 p.409

doi: 10.1038/s41586-019-1029-2

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally p.414

METTL14 recognizes the trimethyl mark on lysine 36 of histone H3 that directs m6A modifications co-transcriptionally.

doi: 10.1038/s41586-019-1016-7

Discovery of a pathway for terminal-alkyne amino acid biosynthesis p.420

doi: 10.1038/s41586-019-1020-y