Ultra-large virtual molecular libraries throw open chemical space p.7

doi: 10.1038/d41586-019-00482-6

Links between gut microbes and depression strengthened p.7

The once-wild idea that intestinal bacteria influence mental health has transformed into a major research pursuit.

doi: 10.1038/d41586-019-00483-5

Chinese effort to clone gene-edited monkeys kicks off p.15

Genetically identical primates could provide improved animal models of human disease, but some researchers raise ethical issues.

doi: 10.1038/d41586-019-00292-w

UC Berkeley bans new research funding from Huawei p.16

Moratorium comes after the US justice department charged the Chinese company with stealing trade secrets.

doi: 10.1038/d41586-019-00451-z

Forget everything you know about 3D printing — the ‘replicator’ is here p.17

Rather than building objects layer by layer, the printer creates whole structures by projecting light into a resin that solidifies.

doi: 10.1038/d41586-018-07798-9

Arctic scientists iced out by US–India radar mission p.18

Managers’ decision to focus their satellite on the Antarctic has upset some researchers who study ice around the northern pole.

doi: 10.1038/d41586-019-00278-8

How machine learning could keep dangerous DNA out of terrorists’ hands p.19

Sophisticated algorithms could help DNA-synthesis companies avoid making dangerous organisms on demand.

doi: 10.1038/d41586-019-00277-9

Scientists protest plan to weaken US gender-discrimination law p.20

More than 89,000 public comments flood in on government proposal to rewrite Title IX, which prohibits sexual harassment in educational settings.

doi: 10.1038/d41586-019-00276-w

Turkey creates its first space agency p.20

A decree by President Recep Tayyip Erdoğan has established a national space agency, but many details are still to come.

doi: 10.1038/d41586-019-00452-y

Death, statistics and a disaster zone: the struggle to count the dead after Hurricane Maria p.22

doi: 10.1038/d41586-019-00442-0

Tainted water: the scientists tracing thousands of fluorinated chemicals in our environment p.26

doi: 10.1038/d41586-019-00441-1

How an activation signal is transmitted through an excitatory receptor p.42

Glutamate receptors facilitate the transmission of excitatory signals in the brain. A series of structures reveals how the shape of one such receptor alters on activation, providing insight that might aid drug discovery.

doi: 10.1038/d41586-018-07885-x

On the road to a gene drive in mammals p.43

A method for making a version of a gene more likely to be inherited than normal, generating what is called a gene drive, might be used to control insect populations. It has now been reported to work in mammals, too.

doi: 10.1038/d41586-019-00185-y

A traffic jam of light p.45

doi: 10.1038/d41586-019-00348-x

Inhibition of ‘jumping genes’ promotes healthy ageing p.46

doi: 10.1038/d41586-018-07553-0

Fate and future climatic role of polar ice sheets p.48

doi: 10.1038/d41586-019-00330-7

Gut immune cells have a role in food metabolism p.49

The gut is an active site of immune defence against disease-causing microbes. A study in mice shows that a type of immune cell in the gut’s wall also helps to regulate sugar and fat metabolism.

doi: 10.1038/d41586-019-00235-5

A dissipatively stabilized Mott insulator of photons p.51

doi: 10.1038/s41586-019-0897-9

Revisiting Antarctic ice loss due to marine ice-cliff instability p.58

doi: 10.1038/s41586-019-0901-4

Global environmental consequences of twenty-first-century ice-sheet melt p.65

doi: 10.1038/s41586-019-0889-9

L1 drives IFN in senescent cells and promotes age-associated inflammation p.73

doi: 10.1038/s41586-018-0784-9

Structural insights into the activation of metabotropic glutamate receptors p.79

doi: 10.1038/s41586-019-0881-4

Formation of massive black holes in rapidly growing pre-galactic gas clouds p.85

doi: 10.1038/s41586-019-0873-4

Real-time vibrations of a carbon nanotube p.89

doi: 10.1038/s41586-018-0861-0

An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin p.94

doi: 10.1038/s41586-019-0894-z

Onset of differentiation is post-transcriptionally controlled in adult neural stem cells p.100

doi: 10.1038/s41586-019-0888-x

Super–Mendelian inheritance mediated by CRISPR–Cas9 in the female mouse germline p.105

doi: 10.1038/s41586-019-0875-2

GPR31-dependent dendrite protrusion of intestinal CX3CR1⁺ cells by bacterial metabolites p.110

doi: 10.1038/s41586-019-0884-1

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease p.115

doi: 10.1038/s41586-018-0849-9

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses p.120

doi: 10.1038/s41586-019-0898-8

Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis p.126

doi: 10.1038/s41586-019-0891-2

Rubisco condensate formation by CcmM in β-carboxysome biogenesis p.131

doi: 10.1038/s41586-019-0880-5

Structure of the post-translational protein translocation machinery of the ER membrane p.136

doi: 10.1038/s41586-018-0856-x