p.5
From forensics to sporting events, disputed age is a source of tension.
doi: 10.1038/d41586-018-06165-y
Volume 561 Issue 7721
Editorials
p.5
Malcolm Turnbull is merely the latest leader to discover that action on emissions remains a difficult step to take.
doi: 10.1038/d41586-018-06164-z
p.6
Influence of his book ‘What is Life?’ celebrated and discussed 75 years on.
doi: 10.1038/d41586-018-06166-x
News
p.13
Scientists say a boom in development in the Western Ghats mountains contributed to the disaster that has killed almost 500 people.
doi: 10.1038/d41586-018-06145-2
p.14
Researchers are devising a clinical-trial protocol to test three medicines in Africa’s latest outbreak.
doi: 10.1038/d41586-018-06132-7
p.15
They say that a more accurate test could help to implement laws that protect minors seeking asylum.
doi: 10.1038/d41586-018-06121-w
p.16
Huge grassroots initiative has founded dozens of research centres across the continent — but the hubs face an uncertain future.
doi: 10.1038/d41586-018-06094-w
p.16
Blazes in North America are becoming larger and more powerful.
doi: 10.1038/d41586-018-06090-0
p.17
Eleven research funders in Europe announce ‘Plan S’ to make all scientific works free to read as soon as they are published.
doi: 10.1038/d41586-018-06178-7
News Features
p.20
Researchers are using AI to decode the language of Chicago gangs. Next they’ll look for opportunities to intervene before online aggression turns deadly.
doi: 10.1038/d41586-018-06169-8
p.24
Zombie satellites, rocket shards and collision debris are creating major traffic risks in orbits around the planet. Researchers are working to reduce the threats posed by more than 20,000 objects in space.
doi: 10.1038/d41586-018-06170-1
News & Views
p.36
The magnetic field of Jupiter has been found to be different from all other known planetary magnetic fields. This result could have major implications for our understanding of the interiors of giant planets.
doi: 10.1038/d41586-018-06095-9
p.37
A previously unknown pathway that enables mammalian cells to recognize infection and trigger an immune response requires a kinase enzyme in the host cell to bind a sugar molecule produced by infecting bacteria.
doi: 10.1038/d41586-018-05854-y
p.38
Methods for imaging sugars attached to proteins — the protein glycoforms — are of interest because glycoforms affect protein movement and localization in cells. A versatile approach is now reported that uses DNA as molecular identity tags.
doi: 10.1038/d41586-018-06092-y
p.40
Exposure to a sulfoximine-based pesticide has substantial adverse effects on bumblebee colonies. This finding suggests that concerns over the risks of exposing bees to insecticides should not be limited to neonicotinoids.
doi: 10.1038/d41586-018-05917-0
p.41
The multiprotein complex PTEX enables malaria-causing parasites to survive inside red blood cells. Studies reveal how PTEX assembles, and identify a function for one of the complex’s proteins, EXP2.
doi: 10.1038/d41586-018-05977-2
p.43
A key step in the development of quantum computers that use neutral atoms as quantum bits is the assembly of tailored 3D arrays of atoms. Two laser-based approaches have now been reported to do this.
doi: 10.1038/d41586-018-06107-8
Review
p.45
Longer human lives have led to a global burden of late-life disease, and so interventions, including changes to lifestyle and medical innovations, are needed to prevent disease and increase late-life health.
doi: 10.1038/s41586-018-0457-8
Articles
p.57
Temporal information that is useful for episodic memory is encoded across a wide range of timescales in the lateral entorhinal cortex, arising inherently from its representation of ongoing experience.
doi: 10.1038/s41586-018-0459-6
p.63
The enzyme glutamine synthetase is active in endothelial cell migration during angiogenesis, through autopalmitoylation and the regulation of RHOJ signalling.
doi: 10.1038/s41586-018-0466-7
p.70
Cryo-electron microscopy analysis of the purified
doi: 10.1038/s41586-018-0469-4
Letters
p.76
Maps of Jupiter’s internal magnetic field at a range of depths reveal an unusual morphology, suggesting that Jupiter’s dynamo, unlike Earth’s, does not operate in a thick, homogeneous shell.
doi: 10.1038/s41586-018-0468-5
p.79
Arbitrarily shaped, defect-free three-dimensional synthetic structures with up to 72 individually controlled atoms are assembled using holographic methods and moving tweezers.
doi: 10.1038/s41586-018-0450-2
p.83
An experiment inspired by Maxwell’s ‘demon’ thought experiment uses a series of reversible operations to fully fill a three-dimensional optical lattice with ultracold atoms and realize a low-entropy state.
doi: 10.1038/s41586-018-0458-7
p.88
All-inorganic perovskite nanocrystals containing caesium and lead provide low-cost, flexible and solution-processable scintillators that are highly sensitive to X-ray irradiation and emit radioluminescence that is colour-tunable across the visible spectrum.
doi: 10.1038/s41586-018-0451-1
p.94
A lithographic patterning and release method is used to create a dense, fluctuating, Brownian system of mobile colloidal kite- and dart-shaped Penrose tiles over large areas that retains quasi-crystalline order.
doi: 10.1038/s41586-018-0464-9
p.100
Soil macroporosity responds rapidly to climate variations and may induce wide-ranging changes in soil hydraulic conductivity by the end of the century.
doi: 10.1038/s41586-018-0463-x
p.104
A well-preserved clutch of Kayentatherium wellesi perinates sheds light on the timing of the evolution of mammalian traits, including reduced clutch sizes and the allometric lengthening of the face during ontogeny.
doi: 10.1038/s41586-018-0441-3
p.109
Chronic exposure to sulfoxaflor (a sulfoximine-based insecticide) has severe sub-lethal effects on bumblebee (Bombus terrestris) colonies; exposed colonies produced fewer workers and fewer reproductive offspring than unexposed control colonies.
doi: 10.1038/s41586-018-0430-6
p.113
Genomic evidence of the offspring of a Neanderthal mother and a Denisovan father suggests that mixing among different hominin groups may have more been frequent than previously appreciated.
doi: 10.1038/s41586-018-0455-x
p.117
In Caenorhabditis elegans, starvation early in life suppresses later sex-specific pruning of synapses through lasting changes in monoaminergic signalling.
doi: 10.1038/s41586-018-0452-0
p.122
The bacterial metabolite ADP-heptose activates NF-κB in host cells via alpha-kinase 1 and the TIFA–TRAF signalling pathway.
doi: 10.1038/s41586-018-0433-3
p.127
The inactivation of tumour suppressor genes at the level of mRNA occurs by the generation of truncated proteins in leukaemia.
doi: 10.1038/s41586-018-0465-8
p.132
The long non-coding RNA NORAD interacts with proteins involved in DNA replication and repair, and controls the ability of RBMX to form a ribonucleoprotein complex that helps to maintain genomic stability.
doi: 10.1038/s41586-018-0453-z
p.137
The structures of tau filaments from patients with the neurodegenerative disorder Pick’s disease show that the filament fold is different from that of the tau filaments found in Alzheimer’s disease.
doi: 10.1038/s41586-018-0454-y
