Volume 560 Issue 7720

Editorials

p.527

A transparent process to publish referees’ reports could benefit science, but not all researchers want their assessments made available.

doi: 10.1038/d41586-018-06045-5

p.527

Physicists are stripping uncertainty from the loosest fundamental constant — Big G.

doi: 10.1038/d41586-018-06044-6

News

p.535

British Heart Foundation award is one of the largest single grants in medical research.

doi: 10.1038/d41586-018-06068-y

p.536

Meteorologist Kelvin Droegemeier offered few clues to his views on the topic when grilled at a US Senate hearing.

doi: 10.1038/d41586-018-06019-7

p.537

But academics say government incentives to publish are part of the problem.

doi: 10.1038/d41586-018-06048-2

p.538

Health system lacks capacity to respond to attacks that use high-powered modern weapons.

doi: 10.1038/d41586-018-06077-x

p.539

How excitement over claims of a high-temperature superconductor reached fever-pitch — and then died away.

doi: 10.1038/d41586-018-06023-x

News Features

p.542

As projects to restore woodlands accelerate, researchers are looking for ways to avoid repeating past failures.

doi: 10.1038/d41586-018-06031-x

News & Views

p.556

Understanding how earthquakes interact is key to reliable earthquake forecasting. A machine-learning study reveals how the stress change induced by earthquakes at geological faults affects these interactions.

doi: 10.1038/d41586-018-06030-y

p.557

Whole-genome sequencing reveals the duplication of a regulatory region, called an enhancer, of the AR gene in treatment-resistant human prostate cancers. The finding shows the importance of analysing non-protein-coding regions of DNA.

doi: 10.1038/d41586-018-06029-5

p.559

Monkeys genetically engineered to lack the gene SIRT6 die a few hours after birth, displaying severe growth defects. This finding reveals a previously unknown role for the SIRT6 protein in primate development.

doi: 10.1038/d41586-018-05970-9

p.560

The enzyme RNA polymerase II, which transcribes DNA, pauses early in transcription and awaits signals to continue. High-resolution structures reveal how it is stopped and efficiently restarted.

doi: 10.1038/d41586-018-05971-8

p.562

The gravitational constant, G, which governs the strength of gravitational interactions, is hard to measure accurately. Two independent determinations of G have been made that have the smallest uncertainties so far.

doi: 10.1038/d41586-018-06028-6

p.563

Manipulation of the transcription factor OsGRF4 can improve the efficiency with which some high-yielding cereal crops use nitrogen. This discovery has implications for sustainable agriculture.

doi: 10.1038/d41586-018-05928-x

Reviews

p.565

Subwavelength-grating metamaterial structures, their main operation principles and their implementation in integrated photonic devices are reviewed.

doi: 10.1038/s41586-018-0421-7

p.573

The rapid development of cell culture and animal models has facilitated a new understanding of ZIKV biology and made it possible to generate multiple ZIKV vaccine candidates, which are advancing through clinical trials.

doi: 10.1038/s41586-018-0446-y

Articles

p.582

The Newtonian gravitational constant is measured with two independent methods, yielding results with relative standard uncertainties of 11.6 parts per million—the lowest uncertainty reported until now.

doi: 10.1038/s41586-018-0431-5

p.589

Stimulating the release of serotonin (5-HT) in the nucleus accumbens in wild-type mice promotes sociability, and rescues deficits in social behaviours in a mouse model of autism.

doi: 10.1038/s41586-018-0416-4

p.595

The balance of DELLA and GRF4 proteins in plants ensures the co-regulation of growth with metabolism and tipping this balance towards GRF4 leads to higher efficiency of nitrogen use.

doi: 10.1038/s41586-018-0415-5

p.601

The cryo-electron microscopy structure of a paused transcription elongation complex of RNA polymerase II bound to DRB sensitivity-inducing factor and negative elongation factor is reported at 3.2 Å resolution.

doi: 10.1038/s41586-018-0442-2

p.607

The cryo-electron microscopy structure of an activated transcription elongation complex of RNA polymerase II bound to DRB sensitivity-inducing factor and the elongation factors PAF1 complex and SPT6 is reported at 3.1 Å resolution.

doi: 10.1038/s41586-018-0440-4

Letters

p.613

The molecular gas in the inner kiloparsec of a submillimetre-bright galaxy is clumpy and gravitationally unstable, collapsing to form stars at a rate that will deplete the gas in about 100 million years.

doi: 10.1038/s41586-018-0443-1

p.617

Electron-scattering experiments reveal that the fraction of high-momentum protons in medium-to-heavy nuclei increases considerably with neutron excess, whereas that of high-momentum neutrons decreases slightly, in contrast to shell-model predictions.

doi: 10.1038/s41586-018-0400-z

p.622

The domain-wall structure and dynamics are found to enhance, rather than inhibit, the high-frequency performance of an intrinsically tunable material, obtaining ultralow loss and exceptional frequency selectivity.

doi: 10.1038/s41586-018-0434-2

p.628

The growth rate of global atmospheric CO2 concentration is faster in drier years, independently of temperature; this relationship is underestimated in current carbon cycle models.

doi: 10.1038/s41586-018-0424-4

p.632

Neural networks trained on data from about 130,000 aftershocks from around 100 large earthquakes improve predictions of the spatial distribution of aftershocks and suggest physical quantities that may control earthquake triggering.

doi: 10.1038/s41586-018-0438-y

p.635

Experimental data from, and mathematical modelling of, colonies of the clonal raider ant Ooceraea biroi demonstrate that increases in group size generate division of labour among similar individuals, increased homeostasis and higher colony fitness.

doi: 10.1038/s41586-018-0422-6

p.639

Satellite data for the period 1982–2016 reveal changes in land use and land cover at global and regional scales that reflect patterns of land change indicative of a human-dominated Earth system.

doi: 10.1038/s41586-018-0411-9

p.644

Integrated analyses of multiple cohorts are used to obtain a better understanding of the immune state of latent infection with Mycobacterium tuberculosis, and factors that mediate and/or predict transitions from latent infection to active disease.

doi: 10.1038/s41586-018-0439-x

p.649

Single-cell RNA sequencing is used to characterize cell types in nasal tissues from human patients with chronic rhinosinusitis, revealing a role for tissue stem cells in allergic inflammatory memory.

doi: 10.1038/s41586-018-0449-8

p.655

The Ras-related GTPase RAP2 is a key intracellular signal transducer by which extracellular matrix rigidity controls mechanosensitive cellular activities through YAP and TAZ.

doi: 10.1038/s41586-018-0444-0

p.661

A cynomolgus monkey model deficient in SIRT6 protein exhibits severe retardation in prenatal development, in which neuronal differentiation is delayed by activation of the H19 long non-coding RNA.

doi: 10.1038/s41586-018-0437-z

p.666

The crystal structure of the Frizzled 4 receptor transmembrane domain is reported to a resolution of 2.4 Å in a ligand-free state.

doi: 10.1038/s41586-018-0447-x