A star that hides its shine draws admiring looks p.141
Astronomers find a planetary nebula with an unusual structure.
doi: 10.1038/d41586-018-05886-4
Volume 560 Issue 7717
리서치 하이라이트
표지 기사： 노화 및 알츠하이머 질환에서 뇌막 림프관의 노폐물 제거 기능
공명 교환 큐비트를 이용한 응집 스핀-광자 결합
내장 리슈만편모충증의 사이클린-의존성 인산화효소 12를 타깃으로 하는 후보 약물
NLRP3 인플라마솜 활성화를 가능하게 하는 새로운 미토콘드리아 DNA 합성
그래핀 나노리본에서 강력한 위상학적 양자 위상 엔지니어링
대기 중 휘발성 물질의 맨틀 내 재순환 연구에 사용하는 제논 방사선 동위원소
척추동물 신경관 및 두개골 기원판의 진화 기원
전세계 토양 상층부 마이크로바이옴의 구조 및 기능
인간에서 항 바이러스성 신호전달을 촉발하는 미토콘드리아 이중 나선 RNA
SVZ 로부터 유래하는 인간 교모종 세포의 기원이 되는 신경 줄기 세포에 존재하는 낮은 레벨 돌연변이
컨텐츠
Editorials
Signs of hope emerge against influenza p.141
A universal vaccine might be some way off, but research into how the immune system responds to the virus will be crucial to achieving that goal.
doi: 10.1038/d41586-018-05885-5
News
Indian scientists race to map Ganges river in 3D p.149
Digital models of the river and surrounding settlements will help authorities to track and reduce waste.
doi: 10.1038/d41586-018-05872-w
The wait is over: Trump taps meteorologist as White House science adviser p.150
Nomination of Kelvin Droegemeier could end long drought at the White House Office of Science and Technology Policy.
doi: 10.1038/d41586-018-05862-y
Thousands of exotic ‘topological’ materials discovered through sweeping search p.151
Haul thrills physicists, who previously knew of just a few hundred of these peculiar materials.
doi: 10.1038/d41586-018-05913-4
Number-theory prodigy among winners of most coveted prize in mathematics p.152
The Fields Medals have been awarded to four researchers who work on number theory, geometry and differential equations.
doi: 10.1038/d41586-018-05864-w
Gigantic review of German science recommends more data and diversity p.153
Big data and diversity lacking at Germany’s biggest science organization.
doi: 10.1038/d41586-018-05818-2
News Features
The mice with human tumours: Growing pains for a popular cancer model p.156
Researchers had high hopes for patient-derived xenografts. Now they are contending with limitations in the clinic and the lab.
doi: 10.1038/d41586-018-05890-8
The ghost of influenza past and the hunt for a universal vaccine p.158
Your first bout of flu may determine how you fare during the next pandemic. That’s why scientists are trying to understand immunologic imprinting.
doi: 10.1038/d41586-018-05889-1
News & Views
Integration of optoelectronics into fibres enhances textiles p.170
An approach has been developed for incorporating optoelectronic devices into polymer fibres, which can be woven into fabrics. Such materials could have applications in both telecommunication and health monitoring.
doi: 10.1038/d41586-018-05873-9
Drug candidate and target for leishmaniasis p.171
Better treatments are needed for the neglected tropical disease leishmaniasis. The development of a compound that tackles the disease in mice, and the identification of the protein it targets, offer a way forward.
doi: 10.1038/d41586-018-05765-y
A lymphatic waste-disposal system implicated in Alzheimer’s disease p.172
The discovery that a set of lymphatic vessels interacts with blood vessels to remove toxic waste products from the brain has implications for cognition, ageing and disorders such as Alzheimer’s disease.
doi: 10.1038/d41586-018-05763-0
Stable and switchable electric polarization in two dimensions p.174
The electric polarization of materials called ferroelectrics is often suppressed by an internal electric field, limiting uses for these materials. The discovery of a thin-film ferroelectric that is resistant to this field represents a major advance.
doi: 10.1038/d41586-018-05807-5
Topological states engineered in narrow strips of graphene p.175
In materials known as graphene nanoribbons, topological states can be precisely engineered and probed, providing an experimental platform for studying electronic topology.
doi: 10.1038/d41586-018-05851-1
Newly made mitochondrial DNA drives inflammation p.176
Activation of the inflammasome protein complex in immune cells is a key step that triggers an innate immune response. It emerges that the synthesis and oxidation of mitochondrial DNA drives this activation step.
doi: 10.1038/d41586-018-05764-z
Articles
Coherent spin–photon coupling using a resonant exchange qubit p.179
Coherent coupling between a three-electron spin qubit and single photons in a microwave resonator is demonstrated, which, unlike previous demonstrations, does not require ferromagnetic components near the qubit.
doi: 10.1038/s41586-018-0365-y
Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease p.185
Meningeal lymphatic dysfunction promotes amyloid-β deposition in the meninges and worsens brain amyloid-β pathology, acting as an aggravating factor in Alzheimer’s disease and in age-associated cognitive decline; improving meningeal lymphatic function could help to prevent or delay age-associated neurological diseases.
doi: 10.1038/s41586-018-0368-8
Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis p.192
A series of compounds are discovered for the treatment of visceral leishmaniasis, and cdc2-related kinase 12 (CRK12) is identified as the probable primary drug target.
doi: 10.1038/s41586-018-0356-z
New mitochondrial DNA synthesis enables NLRP3 inflammasome activation p.198
New mitochondrial DNA synthesis links the priming and activation of the NLRP3 inflammasome.
doi: 10.1038/s41586-018-0372-z
Letters
Topological band engineering of graphene nanoribbons p.204
A topologically engineered graphene nanoribbon superlattice is presented that hosts a one-dimensional array of half-filled, in-gap localized electronic states, enabling band engineering.
doi: 10.1038/s41586-018-0376-8
Engineering of robust topological quantum phases in graphene nanoribbons p.209
Graphene nanoribbons are used to design robust nanomaterials with controlled periodic coupling of topological boundary states to create quasi-one-dimensional trivial and non-trivial electronic quantum phases.
doi: 10.1038/s41586-018-0375-9
Diode fibres for fabric-based optical communications p.214
A scalable thermal drawing process is used to integrate light-emitting and photodetecting diodes into textile-ready polymer fibres, which can be woven into fabrics with possible optical communication and health monitoring applications.
doi: 10.1038/s41586-018-0390-x
Extensive loss of past permafrost carbon but a net accumulation into present-day soils p.219
Comparing the northern permafrost region of the Last Glacial Maximum with the same area today shows that the soil carbon stock has now increased, suggesting that permafrost carbon made no net contribution to preindustrial atmospheric carbon.
doi: 10.1038/s41586-018-0371-0
Xenon isotopic constraints on the history of volatile recycling into the mantle p.223
Mantle xenon isotope systematics reveals that no substantial recycling of atmospheric xenon into the deep Earth occurred before 2.5 billion years ago, indicating that downwellings were drier in the Archaean era than today.
doi: 10.1038/s41586-018-0388-4
Shared evolutionary origin of vertebrate neural crest and cranial placodes p.228
Similarities between the patterning of the lateral plate in Ciona and of the neural plate ectoderm in vertebrates indicate that compartmentalization of the lateral plate ectoderm preceded the advent of vertebrates.
doi: 10.1038/s41586-018-0385-7
Structure and function of the global topsoil microbiome p.233
Metagenomic, chemical and biomass analyses of topsoil samples from around the world reveal spatial and environmental trends in microbial community composition and genetic diversity.
doi: 10.1038/s41586-018-0386-6
Mitochondrial double-stranded RNA triggers antiviral signalling in humans p.238
Mitochondrial double-stranded RNA can induce an interferon response if released into the cytoplasm, but self-recognition is prevented by SUV3 helicase and PNPase exoribonuclease.
doi: 10.1038/s41586-018-0363-0
Human glioblastoma arises from subventricular zone cells with low-level driver mutations p.243
Human neural stem cells from the subventricular zone are identified as the cells of origin that contain the driver mutations for glioblastomas.
doi: 10.1038/s41586-018-0389-3
CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window p.248
A system that targets DNA polymerase activity with CRISPR-guided nickases to provide genetic diversification at user-defined loci enables forward genetic approaches.
doi: 10.1038/s41586-018-0384-8
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth p.253
Selective inhibitors of KAT6A and KAT6B inhibit MYST-catalysed histone acetylation, induce cell cycle exit and cellular senescence without causing DNA damage, and arrest lymphoma progression in mouse models.
doi: 10.1038/s41586-018-0387-5
Cryo-EM of the dynamin polymer assembled on lipid membrane p.258
A cryo-electron microscopy structure of human dynamin-1 demonstrates conformational changes and sheds light on the fission of membranes during endocytosis.
doi: 10.1038/s41586-018-0378-6
Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM p.263
A cryo-electron microscopy structure of the mammalian mitochondrial translation initiation complex reveals unique features that are necessary to initiate mitochondrial translation and highlights a possible membrane-targeting peptide.
doi: 10.1038/s41586-018-0373-y
