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As a commendable European law on personal data comes into force, the research community must not let excessive caution about data sharing, however understandable, become the default position.doi: 10.1038/d41586-018-05220-y
Volume 557 Issue 7706
리서치 하이라이트
표지 기사： 즉시 응답형 택시 시스템 구축에 문제가 있는 최소 운행 대수 택시 시스템
지금까지 밝혀져 있지 않던 수천 가지 세균 유전자의 기능을 확인하기 위한 돌연변이 표현형 분석
수선 기능 결여 tRNA 합성효소에 의해서 유발되는 신경 소실을 예방하는 ANKRD16
세레이트를 통해 miRNA 생성을 방지하는 pri-miRNA 리모델링하는 SWI2/SNF2 ATPase CHR2
플라즈마 렌즈를 통해서 증폭되는 펄서 방출
뜨거운 토성형 태양계 외부 행성에서 관찰된 풍부한 나트륨 함량
인간 뇌 크기 진화에 가장 많은 영향을 준 생태학적 및 사회학적 인자들
다양한 관절염을 유발하는 알파 바이러스에 대한 수용체 역할을 하는 Mxra8
암 조직에 침투하는 CD8+ T세포들 중에서 방관자 역할을 하는 T세포를 구분할 수 있는 CD39
컨텐츠
Editorials
p.467
An updated estimate of the economic damage of climate change makes a strong financial case for urgent action on greenhouse-gas emissions.doi: 10.1038/d41586-018-05219-5
p.468
Electric cars are gaining ground fast but face fossil-fuel favouritism in the showroom.doi: 10.1038/d41586-018-05218-6
News
p.475
International health organizations are in discussions with the Democratic Republic of Congo about how and whether to deploy treatments in addition to a vaccine.doi: 10.1038/d41586-018-05205-x
p.476
The government’s proposals include stricter rules, and tougher penalties for researchers who break existing ones.doi: 10.1038/d41586-018-05001-7
p.477
Scientists scramble to analyse data from Kilauea, which shot ash 9 kilometres into the atmosphere.doi: 10.1038/d41586-018-05206-w
p.478
Queqiao probe will act as relay station for a future lunar lander, and carries two radio-astronomy experiments that will explore the early Universe.doi: 10.1038/d41586-018-05231-9
p.479
Sweden is latest country to hold out on journal subscriptions, while negotiators share tactics to broker new deals with publishers.doi: 10.1038/d41586-018-05191-0
News Features
p.482
The intestinal microbiome seems to influence how well some cancer drugs work. But is the science ripe for clinical trials?doi: 10.1038/d41586-018-05208-8
News & Views
p.494
Radio waves produced by cosmic lighthouses called pulsars are distorted by surrounding material. Observations show that this material can act as a lens, focusing the waves and boosting the brightness of the pulsar.doi: 10.1038/d41586-018-05185-y
p.495
The identification of genetic mutations that can hinder the development of human limbs has led to the discovery of an unanticipated mode of regulation for the WNT signalling pathway during limb development.doi: 10.1038/d41586-018-04820-y
p.496
An innovative computational analysis of factors that might have influenced human brain evolution suggests that ecological, rather than social, factors had a key role in the evolution of large, rapidly developing brains.doi: 10.1038/d41586-018-05197-8
p.498
A study finds that meeting climate-change mitigation targets will lead to a substantial reduction in economic damages. Here, economists present opposing views on the approach used by studies such as this one.doi: 10.1038/d41586-018-05198-7
p.499
Several neurodegenerative disorders are linked to the build-up of abnormal α-synuclein protein in distinct cell types. It emerges that differing intracellular factors dictate the properties of this protein in each cell type.doi: 10.1038/d41586-018-04988-3
p.500
Mutations in the gene KDM6A drive an aggressive subtype of pancreatic cancer by causing repositioning of an enzyme complex that modifies histone proteins associated with DNA, leading to altered gene expression.doi: 10.1038/d41586-018-05129-6
p.501
Excitations called plasmons have the potential to miniaturize photonic devices, but are often short-lived. Microscopy reveals that plasmons in the material graphene can overcome this limitation at low temperatures.doi: 10.1038/d41586-018-05190-1
Articles
p.503
A large-scale mutagenesis screen identifies mutant phenotypes for over 11,000 protein-coding genes in bacteria that had previously not been assigned a specific function.doi: 10.1038/s41586-018-0124-0
p.510
ANKRD16 attenuates neurodegeneration induced by a mutation in the editing domain of alanyl tRNA synthetase by directly accepting mis-activated serine from the synthetase before transfer to the tRNA, establishing a new mechanism by which editing defects are prevented.doi: 10.1038/s41586-018-0137-8
p.516
The chromatin remodelling protein CHR2 interacts with Serrate in Arabidopsis to regulate microRNA biogenesis.doi: 10.1038/s41586-018-0135-x
Letters
p.522
Radiation from the ‘black widow’ pulsar B1957+20 is amplified when a companion brown dwarf passes in front of the source, suggesting that plasma flowing from the companion acts as a lens.doi: 10.1038/s41586-018-0133-z
p.526
The optical transmission spectrum for the ‘hot Saturn’ exoplanet WASP-96b reveals a clear atmosphere, an atmospheric sodium abundance and hence its metallicity, which is consistent with the metallicity trend observed in Solar System planets and exoplanets.doi: 10.1038/s41586-018-0101-7
p.530
The fundamental limits to plasmon damping in graphene are determined using nanoscale infrared imaging at cryogenic temperatures, and plasmon polaritons are observed to propagate over 10 micrometres in high-mobility encapsulated graphene.doi: 10.1038/s41586-018-0136-9
p.534
An optimal computationally efficient solution to the problem of finding the minimum taxi fleet size using a vehicle-sharing network is presented.doi: 10.1038/s41586-018-0095-1
p.539
Liquid crystals are used to self-report and self-regulate either continuous or transient release of droplets or microparticles trapped within them in response to thermal, chemical, mechanical or biological stimuli.doi: 10.1038/s41586-018-0098-y
p.545
The use of triple-oxygen-isotope data from continental shales spanning the past 3.7 billion years suggests that continental crust with near-modern average elevation and extent emerged about 2.5 billion years ago.doi: 10.1038/s41586-018-0131-1
p.549
If the world can meet the target of limiting global warming to 1.5 °C, economic damage will probably be greatly reduced, especially in poorer countries.doi: 10.1038/s41586-018-0071-9
p.554
Using estimates of metabolic costs of the brain and body, mathematical predictions suggest that the evolution of adult Homo sapiens-sized brains and bodies is driven by ecological rather than social challenges and is perhaps strongly promoted by culture.doi: 10.1038/s41586-018-0127-x
p.558
Distinct strains of misfolded α-synuclein proteins, which aggregate in neurons in Lewy body diseases or in oligodendrocytes in multiple system atrophy, are formed as a consequence of differences between intracellular environments.doi: 10.1038/s41586-018-0104-4
p.564
Independently of the LGR4/5/6 receptors, RSPO2 acts as a direct antagonistic ligand to RNF43 and ZNRF3 during embryogenesis, and specifies the position and number of limbs that an embryo should form.doi: 10.1038/s41586-018-0118-y
p.570
The cell adhesion molecule Mxra8 is identified as a receptor for multiple arthritogenic alphaviruses such as chikungunya virus, and anti-Mxra8 monoclonal antibodies are shown to reduce rates of chikungunya virus infection in mice and a range of human cells.doi: 10.1038/s41586-018-0121-3
p.575
Human lung and colorectal tumours contain a population of tumour-infiltrating lymphocytes that are specific for tumour-unrelated antigens and, unlike tumour-antigen-specific tumour-infiltrating lymphocytes, do not express CD39.doi: 10.1038/s41586-018-0130-2
p.580
Microbial signals are crucial to the development of pre-leukaemic myeloproliferation, which can be induced by disrupting the intestinal barrier or by introducing systemic bacterial stimuli in Tet2-deficient mice.doi: 10.1038/s41586-018-0125-z
p.585
In response to amino acid stimulation, the ubiquitin E3 ligase CUL3–KLHL22 promotes the activation of mTORC1, which may drive tumour growth in breast cancer.doi: 10.1038/s41586-018-0128-9
p.590
Crystal structures and molecular dynamics simulations of voltage-gated sodium channels containing mutations that cause hypokalaemic and normokalaemic periodic paralysis indicate the pathogenic mechanisms of these conditions and suggest a target for the design of potential therapeutic and symptomatic drugs.doi: 10.1038/s41586-018-0120-4
