Volume 557 Issue 7705


A slow road for stem cells p.279

The steady and careful development that has guided treatments using embryonic stem cells should be applied to therapies derived from adult stem cells, too.

doi: 10.1038/d41586-018-05160-7


News Features

News & Views

AI mimics brain codes for navigation p.313

An artificial-intelligence technique called deep learning has now been used to model spatial navigation. The system develops a representation of space similar to that of the grid cells found in the mammalian brain.

doi: 10.1038/d41586-018-04992-7

Will ocean zones with low oxygen levels expand or shrink? p.314

Computer simulations show that areas of the ocean that have low levels of dissolved oxygen will expand, but then shrink, in response to global warming — adding to an emerging picture of the finely balanced processes involved.

doi: 10.1038/d41586-018-05034-y

More than one way to induce a neuron p.316

Seventy-six pairs of transcription factors can induce mouse connective-tissue cells to adopt a neuron-like identity in vitro. This discovery provides insights into both neuronal development and cell reprogramming.

doi: 10.1038/d41586-018-04978-5

Evidence of illegal emissions of ozone-depleting chemicals p.317

Chlorofluorocarbons are the main class of chemical that depleted the ozone layer in the stratosphere. Measurements reveal that emissions of these compounds are rising again, despite international rules restricting their use.

doi: 10.1038/d41586-018-05110-3


137 ancient human genomes from across the Eurasian steppes p.369

Sequences of 137 ancient and 502 modern human genomes illuminate the population history of the Eurasian steppes after the Bronze Age and document the replacement of Indo-European speakers of West Eurasian ancestry by Turkic-speaking groups of East Asian ancestry.

doi: 10.1038/s41586-018-0094-2

Diverse reprogramming codes for neuronal identity p.375

A screen in which combinatorial pairs of transcription factors are exogenously expressed in fibroblasts identifies different combinations that reprogram these cells into induced neuronal cells with diverse functional properties.

doi: 10.1038/s41586-018-0103-5


The pressure distribution inside the proton p.396

Measurements of the quark pressure distribution in the proton reveal a strong repulsive pressure near the proton’s centre (stronger than the pressure in neutron stars) and a binding pressure at greater distances.

doi: 10.1038/s41586-018-0060-z